PMID- 37622917
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20230828
IS  - 2079-6374 (Electronic)
IS  - 2079-6374 (Linking)
VI  - 13
IP  - 8
DP  - 2023 Aug 20
TI  - A Miniature Biomedical Sensor for Rapid Detection of Schistosoma japonicum 
      Antibodies.
LID - 10.3390/bios13080831 [doi]
LID - 831
AB  - Schistosomiasis, typically characterized by chronic infection in endemic regions, 
      has the potential to affect liver tissue and pose a serious threat to human 
      health. Detecting and screening for this disease early on is crucial for its 
      prevention and control. However, existing methods encounter challenges such as 
      low sensitivity, time-consuming processes, and complex sample handling. To 
      address these challenges, we report a soluble egg antigen (SEA)-based 
      functionalized gridless and meander-type AlGaN/GaN high electron mobility 
      transistors (HEMT) sensor for the highly sensitive detection of antibodies to 
      Schistosoma japonicum. Immobilization of the self-assembled membrane on the gate 
      surface was verified using a semiconductor parameter analyzer, scanning electron 
      microscope (SEM), and atomic force microscopy (AFM). The developed biosensor 
      demonstrates remarkable performance in detecting anti-SEA, exhibiting a linear 
      concentration range of 10 ng/mL to 100 mug/mL and a sensitivity of 0.058 mA/log 
      (ng/mL). It also exhibits similar excellent performance in serum systems. With 
      advantages such as rapid detection, high sensitivity, miniaturization, and 
      label-free operation, this biosensor can fulfill the requirements for blood 
      defense.
FAU - Hu, Shengjie
AU  - Hu S
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
FAU - Jiang, Xuecheng
AU  - Jiang X
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
FAU - Yang, Liang
AU  - Yang L
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
FAU - Tang, Xue
AU  - Tang X
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
FAU - Yang, Guofeng
AU  - Yang G
AUID- ORCID: 0000-0002-4409-9685
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
FAU - Hu, Yuanyuan
AU  - Hu Y
AD  - Changsha Semiconductor Technology and Application Innovation Research Institute, 
      College of Semiconductors (College of Integrated Circuits), Hunan University, 
      Changsha 410082, China.
FAU - Wang, Jie
AU  - Wang J
AD  - National Health Commission Key Laboratory of Parasitic Disease Control and 
      Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control 
      Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of 
      Parasitic Diseases, Wuxi 214064, China.
FAU - Lu, Naiyan
AU  - Lu N
AUID- ORCID: 0000-0001-9778-2819
AD  - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
LA  - eng
GR  - No. ZDXYS202207/the Jiangsu Province Capability Improvement Project through 
      Science, Technology and Education/
GR  - No. wk023-006/the Open Project of National Health Commission Key Laboratory of 
      Parasitic Disease Control and Prevention/
GR  - No. BE2020756/the Key Research and Development Program of Jiangsu Province/
PT  - Journal Article
DEP - 20230820
PL  - Switzerland
TA  - Biosensors (Basel)
JT  - Biosensors
JID - 101609191
RN  - 0 (Antibodies)
SB  - IM
MH  - Humans
MH  - Animals
MH  - *Schistosoma japonicum
MH  - Antibodies
MH  - Electrons
MH  - Liver
MH  - Microscopy, Atomic Force
PMC - PMC10452731
OTO - NOTNLM
OT  - AlGaN/GaN high electron mobility transistors (HEMT)
OT  - Schistosoma japonicum
OT  - biomedical sensor
OT  - rapid detection
OT  - soluble egg antigens (SEA)
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/25 12:42
MHDA- 2023/08/28 06:43
PMCR- 2023/08/20
CRDT- 2023/08/25 08:43
PHST- 2023/07/31 00:00 [received]
PHST- 2023/08/15 00:00 [revised]
PHST- 2023/08/18 00:00 [accepted]
PHST- 2023/08/28 06:43 [medline]
PHST- 2023/08/25 12:42 [pubmed]
PHST- 2023/08/25 08:43 [entrez]
PHST- 2023/08/20 00:00 [pmc-release]
AID - bios13080831 [pii]
AID - biosensors-13-00831 [pii]
AID - 10.3390/bios13080831 [doi]
PST - epublish
SO  - Biosensors (Basel). 2023 Aug 20;13(8):831. doi: 10.3390/bios13080831.