PMID- 37623837
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230829
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 13
IP  - 8
DP  - 2023 Jul 28
TI  - Metabolites Potentially Derived from Gut Microbiota Associated with Podocyte, 
      Proximal Tubule, and Renal and Cerebrovascular Endothelial Damage in Early 
      Diabetic Kidney Disease in T2DM Patients.
LID - 10.3390/metabo13080893 [doi]
LID - 893
AB  - Complications due to type 2 diabetes mellitus (T2DM) such as diabetic kidney 
      disease (DKD) and cerebral small vessel disease (CSVD) have a powerful impact on 
      mortality and morbidity. Our current diagnostic markers have become outdated as 
      T2DM-related complications continue to develop. The aim of the investigation was 
      to point out the relationship between previously selected metabolites which are 
      potentially derived from gut microbiota and indicators of endothelial, proximal 
      tubule (PT), and podocyte dysfunction, and neurosonological indices. The study 
      participants were 20 healthy controls and 90 T2DM patients divided into three 
      stages: normoalbuminuria, microalbuminuria, and macroalbuminuria. Serum and urine 
      metabolites were determined by untargeted and targeted metabolomic techniques. 
      The markers of endothelial, PT and podocyte dysfunction were assessed by ELISA 
      technique, and the neurosonological indices were provided by an ultrasound device 
      with high resolution (MYLAB 8-ESAOTE Italy). The descriptive statistical analysis 
      was followed by univariable and multivariable linear regression analyses. In 
      conclusion, in serum, arginine (sArg), butenoylcarnitine (sBCA), and indoxyl 
      sulfate (sIS) expressed a biomarker potential in terms of renal endothelial 
      dysfunction and carotid atherosclerosis, whereas sorbitol (sSorb) may be a 
      potential biomarker of blood-brain barrier (BBB) dysfunction. In urine, BCA and 
      IS were associated with markers of podocyte damage, whereas PCS correlated with 
      markers of PT dysfunction.
FAU - Balint, Lavinia
AU  - Balint L
AUID- ORCID: 0000-0003-2125-5419
AD  - Department of Internal Medicine II-Division of Nephrology, "Victor Babes" 
      University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, County Emergency 
      Hospital Timisoara, 300041 Timisoara, Romania.
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
FAU - Socaciu, Carmen
AU  - Socaciu C
AUID- ORCID: 0000-0002-7352-5057
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
AD  - Research Center for Applied Biotechnology and Molecular Therapy Biodiatech, SC 
      Proplanta, Trifoiului 12G, 400478 Cluj-Napoca, Romania.
FAU - Socaciu, Andreea Iulia
AU  - Socaciu AI
AD  - Department of Occupational Health, University of Medicine and Pharmacy "Iuliu 
      Hatieganu", Victor Babes 8, 400347 Cluj-Napoca, Romania.
FAU - Vlad, Adrian
AU  - Vlad A
AUID- ORCID: 0000-0002-1824-2628
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
AD  - Department of Internal Medicine II-Division of Diabetes and Metabolic Diseases, 
      "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 
      County Emergency Hospital Timisoara, 300041 Timisoara, Romania.
FAU - Gadalean, Florica
AU  - Gadalean F
AD  - Department of Internal Medicine II-Division of Nephrology, "Victor Babes" 
      University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, County Emergency 
      Hospital Timisoara, 300041 Timisoara, Romania.
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
FAU - Bob, Flaviu
AU  - Bob F
AD  - Department of Internal Medicine II-Division of Nephrology, "Victor Babes" 
      University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, County Emergency 
      Hospital Timisoara, 300041 Timisoara, Romania.
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
FAU - Milas, Oana
AU  - Milas O
AD  - Department of Internal Medicine II-Division of Nephrology, "Victor Babes" 
      University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, County Emergency 
      Hospital Timisoara, 300041 Timisoara, Romania.
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
FAU - Cretu, Octavian Marius
AU  - Cretu OM
AD  - Department of Surgery I-Division of Surgical Semiology I, "Victor Babes" 
      University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, Emergency Clinical 
      Municipal Hospital Timisoara, 300041 Timisoara, Romania.
FAU - Suteanu-Simulescu, Anca
AU  - Suteanu-Simulescu A
AD  - Department of Internal Medicine II-Division of Nephrology, "Victor Babes" 
      University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, County Emergency 
      Hospital Timisoara, 300041 Timisoara, Romania.
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
FAU - Glavan, Mihaela
AU  - Glavan M
AD  - Department of Internal Medicine II-Division of Nephrology, "Victor Babes" 
      University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, County Emergency 
      Hospital Timisoara, 300041 Timisoara, Romania.
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
FAU - Ienciu, Silvia
AU  - Ienciu S
AD  - Department of Internal Medicine II-Division of Nephrology, "Victor Babes" 
      University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, County Emergency 
      Hospital Timisoara, 300041 Timisoara, Romania.
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
FAU - Mogos, Maria
AU  - Mogos M
AD  - Department of Internal Medicine II-Division of Nephrology, "Victor Babes" 
      University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, County Emergency 
      Hospital Timisoara, 300041 Timisoara, Romania.
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
FAU - Jianu, Dragos Catalin
AU  - Jianu DC
AUID- ORCID: 0000-0002-7827-818X
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
AD  - Department of Neurosciences-Division of Neurology, "Victor Babes" University of 
      Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, County Emergency Hospital 
      Timisoara, 300041 Timisoara, Romania.
AD  - Centre for Cognitive Research in Neuropsychiatric Pathology (Neuropsy-Cog), 
      Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie 
      Murgu Sq. No. 2, 300041 Timisoara, Romania.
FAU - Ursoniu, Sorin
AU  - Ursoniu S
AUID- ORCID: 0000-0001-9215-5154
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
AD  - Centre for Cognitive Research in Neuropsychiatric Pathology (Neuropsy-Cog), 
      Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie 
      Murgu Sq. No. 2, 300041 Timisoara, Romania.
AD  - Department of Functional Sciences III, Division of Public Health and History of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
AD  - Centre for Translational Research and Systems Medicine, Faculty of Medicine, 
      "Victor Babes" University of Medicine and Pharmacy, Eftimie, Murgu Sq. No. 2, 
      300041 Timisoara, Romania.
FAU - Dumitrascu, Victor
AU  - Dumitrascu V
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
AD  - Department of Biochemistry and Pharmacology IV, Division of Pharmacology, "Victor 
      Babes" University of Medicine and Pharmacy, No. 2, Eftimie Murgu Sq., 300041 
      Timisoara, Romania.
FAU - Vlad, Daliborca
AU  - Vlad D
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
AD  - Department of Biochemistry and Pharmacology IV, Division of Pharmacology, "Victor 
      Babes" University of Medicine and Pharmacy, No. 2, Eftimie Murgu Sq., 300041 
      Timisoara, Romania.
FAU - Popescu, Roxana
AU  - Popescu R
AUID- ORCID: 0000-0002-9387-1141
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
AD  - Department of Microscopic Morphology II, Division of Cell and Molecular Biology 
      II, "Victor Babes" University of Medicine and Pharmacy, No. 2, Eftimie Murgu Sq., 
      300041 Timisoara, Romania.
FAU - Petrica, Ligia
AU  - Petrica L
AUID- ORCID: 0000-0003-3138-3051
AD  - Department of Internal Medicine II-Division of Nephrology, "Victor Babes" 
      University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, County Emergency 
      Hospital Timisoara, 300041 Timisoara, Romania.
AD  - Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of 
      Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. 
      No. 2, 300041 Timisoara, Romania.
AD  - Centre for Cognitive Research in Neuropsychiatric Pathology (Neuropsy-Cog), 
      Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie 
      Murgu Sq. No. 2, 300041 Timisoara, Romania.
AD  - Centre for Translational Research and Systems Medicine, Faculty of Medicine, 
      "Victor Babes" University of Medicine and Pharmacy, Eftimie, Murgu Sq. No. 2, 
      300041 Timisoara, Romania.
LA  - eng
GR  - 5439-3/5.03.2021/Centre for Molecular Research in Nephrology and Vascular 
      Disease, Faculty of Medicine," Victor Babes" University of Medicine and Pharmacy, 
      Timisoara, Romania/
PT  - Journal Article
DEP - 20230728
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC10456401
OTO - NOTNLM
OT  - CSVD
OT  - arginine
OT  - butenoylcarnitine
OT  - early DKD biomarkers
OT  - indoxyl sulfate
OT  - metabolites
OT  - p-cresyl sulfate
OT  - sorbitol
COIS- The authors declare no conflict of interests.
EDAT- 2023/08/25 12:42
MHDA- 2023/08/25 12:43
PMCR- 2023/07/28
CRDT- 2023/08/25 09:33
PHST- 2023/06/30 00:00 [received]
PHST- 2023/07/26 00:00 [revised]
PHST- 2023/07/26 00:00 [accepted]
PHST- 2023/08/25 12:43 [medline]
PHST- 2023/08/25 12:42 [pubmed]
PHST- 2023/08/25 09:33 [entrez]
PHST- 2023/07/28 00:00 [pmc-release]
AID - metabo13080893 [pii]
AID - metabolites-13-00893 [pii]
AID - 10.3390/metabo13080893 [doi]
PST - epublish
SO  - Metabolites. 2023 Jul 28;13(8):893. doi: 10.3390/metabo13080893.