PMID- 37624281
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230829
IS  - 2306-7381 (Electronic)
IS  - 2306-7381 (Linking)
VI  - 10
IP  - 8
DP  - 2023 Aug 1
TI  - Litters of Various-Sized Mummies (LVSM) and Stillborns after Porcine Reproductive 
      and Respiratory Syndrome Virus Type 1 Infection-A Case Report.
LID - 10.3390/vetsci10080494 [doi]
LID - 494
AB  - Diverse origins and causes are described for papyraceous mummifications of 
      porcine foetuses, but the porcine reproductive and respiratory syndrome virus 
      (PRRSV) is not one of them. In contrast, PRRSV is unlikely to cause mid-term 
      placental transmission but may cause late-term abortions and weakness of piglets. 
      This case report describes a sudden occurrence of mummified foetuses of various 
      sizes and stillborns and delayed birth (>115 days) in more than 50% of sows from 
      one farrowing batch, while newborn piglets were mostly vital. Neither increased 
      embryonic death nor infertility was reported. Three litters with mummies, 
      autolysed piglets and stillborn piglets were investigated, and infections with 
      porcine parvoviruses, porcine teschoviruses, porcine circoviruses, 
      encephalomyocarditis virus, Leptospira spp. and Chlamydia spp. were excluded. 
      Instead, high viral loads of PRRSV were detected in the thymus pools of piglets 
      at all developmental stages, even in piglets with a crown-rump length between 80 
      and 150 mm, suggesting a potential mid-term in utero transmission of the virus. 
      Genomic regions encoding structural proteins (ORF2-7) of the virus were sequenced 
      and identified the virulent PRRSV-1 strain AUT15-33 as the closest relative. This 
      case report confirms the diversity of PRRSV and its potential involvement in 
      foetal death in mid-gestation.
FAU - Unterweger, Christine
AU  - Unterweger C
AUID- ORCID: 0000-0003-4965-2088
AD  - University Clinic for Swine, Department for Farm Animals and Veterinary Public 
      Health, University of Veterinary Medicine, 1210 Vienna, Austria.
FAU - Kreutzmann, Heinrich
AU  - Kreutzmann H
AD  - University Clinic for Swine, Department for Farm Animals and Veterinary Public 
      Health, University of Veterinary Medicine, 1210 Vienna, Austria.
FAU - Buenger, Moritz
AU  - Buenger M
AUID- ORCID: 0000-0002-7941-8850
AD  - University Clinic for Swine, Department for Farm Animals and Veterinary Public 
      Health, University of Veterinary Medicine, 1210 Vienna, Austria.
FAU - Klingler, Eva
AU  - Klingler E
AD  - Vetpraxis Hegerberg, 3053 Laaben, Austria.
FAU - Auer, Angelika
AU  - Auer A
AD  - Institute of Virology, Department of Pathobiology, University of Veterinary 
      Medicine, 1210 Vienna, Austria.
FAU - Rumenapf, Till
AU  - Rumenapf T
AD  - Institute of Virology, Department of Pathobiology, University of Veterinary 
      Medicine, 1210 Vienna, Austria.
FAU - Truyen, Uwe
AU  - Truyen U
AD  - Institute for Animal Hygiene and Veterinary Public Health, Faculty of Veterinary 
      Medicine, University of Leipzig, 04103 Leipzig, Germany.
FAU - Ladinig, Andrea
AU  - Ladinig A
AD  - University Clinic for Swine, Department for Farm Animals and Veterinary Public 
      Health, University of Veterinary Medicine, 1210 Vienna, Austria.
LA  - eng
PT  - Case Reports
DEP - 20230801
PL  - Switzerland
TA  - Vet Sci
JT  - Veterinary sciences
JID - 101680127
PMC - PMC10458132
OTO - NOTNLM
OT  - LVSM
OT  - PRRSV AUT15-33
OT  - PRRSV-1
OT  - SMEDI
OT  - mid-gestation
OT  - modified live virus vaccine
OT  - mummifications
OT  - porcine reproductive and respiratory syndrome virus
OT  - prolonged gestation
OT  - stillborn piglets
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/25 12:42
MHDA- 2023/08/25 12:43
PMCR- 2023/08/01
CRDT- 2023/08/25 10:43
PHST- 2023/05/29 00:00 [received]
PHST- 2023/07/11 00:00 [revised]
PHST- 2023/07/26 00:00 [accepted]
PHST- 2023/08/25 12:43 [medline]
PHST- 2023/08/25 12:42 [pubmed]
PHST- 2023/08/25 10:43 [entrez]
PHST- 2023/08/01 00:00 [pmc-release]
AID - vetsci10080494 [pii]
AID - vetsci-10-00494 [pii]
AID - 10.3390/vetsci10080494 [doi]
PST - epublish
SO  - Vet Sci. 2023 Aug 1;10(8):494. doi: 10.3390/vetsci10080494.