PMID- 37624316
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230828
IS  - 2306-7381 (Electronic)
IS  - 2306-7381 (Linking)
VI  - 10
IP  - 8
DP  - 2023 Aug 21
TI  - Meloxicam in Combination with Mitoxantrone or Vinblastine as First-Line Treatment 
      for Non-Resectable Urothelial Cell Carcinoma in Dogs.
LID - 10.3390/vetsci10080529 [doi]
LID - 529
AB  - Cyclooxygenase (COX) inhibitors have been demonstrated to have antitumour 
      activity in canine urothelial cell carcinoma (UCC), given as a sole treatment or 
      in combination with chemotherapy. The purpose of this retrospective 
      multi-institutional study was to assess the efficacy of meloxicam in combination 
      with mitoxantrone or vinblastine as a first-line treatment for non-resectable 
      canine UCC. Gastrointestinal adverse effects (AEs) of these treatment 
      combinations were also assessed. A total of 28 dogs met the inclusion criteria, 
      21/28 dogs received mitoxantrone and meloxicam, and 7/28 received vinblastine and 
      meloxicam. Tumour response (TR) and AE were evaluated according to Veterinary 
      Co-Operative Oncology Group (VCOG) criteria. The endpoint of the study was the 
      time to tumour progression (TTP). The mitoxantrone-group induced 24% partial 
      response and 62% stable disease, while the vinblastine-group induced 14% and 86%, 
      respectively. Median TTP was 84 days (mitoxantrone and meloxicam, 70 days; and 
      vinblastine and meloxicam, 178 days). The presence of metastatic disease 
      significantly decreased TTP (p = 0.007). Gastrointestinal AEs were reported in 
      21.4% of the patients, with the most common being VCOG grade 1-2 diarrhoea. 
      Meloxicam is a well-tolerated NSAID when combined with mitoxantrone or 
      vinblastine as first-line treatment for non-resectable canine UCC.
FAU - Ciriano Cerda, Estel la
AU  - Ciriano Cerda E
AUID- ORCID: 0000-0001-8985-1642
AD  - Northwest Veterinary Specialists, Part of Linnaeus Veterinary Limited, Ashville 
      Point, Beechwood, Sutton Weaver, Runcorn WA7 3FW, UK.
FAU - Zajc, Alenka Lavra
AU  - Zajc AL
AD  - Northwest Veterinary Specialists, Part of Linnaeus Veterinary Limited, Ashville 
      Point, Beechwood, Sutton Weaver, Runcorn WA7 3FW, UK.
FAU - Finotello, Riccardo
AU  - Finotello R
AUID- ORCID: 0000-0002-1932-211X
AD  - Department of Small Animal Clinical Sciences, Department of Veterinary Anatomy 
      Physiology and Pathology, Institute of Infection Veterinary and Ecological 
      Sciences, University of Liverpool, Chester High Rd, Neston CH64 7TE, UK.
FAU - Macdonald, Kirsty
AU  - Macdonald K
AD  - Department of Small Animal Clinical Sciences, Department of Veterinary Anatomy 
      Physiology and Pathology, Institute of Infection Veterinary and Ecological 
      Sciences, University of Liverpool, Chester High Rd, Neston CH64 7TE, UK.
FAU - Lyseight, Filipa
AU  - Lyseight F
AD  - Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Cambridgeshire 
      CB8 0UH, UK.
FAU - Van Den Steen, Nele
AU  - Van Den Steen N
AD  - Cave Veterinary Specialists, George's Farm, West Buckland, Nr. Wellington TA21 
      9LE, UK.
FAU - Sanchez Gonzalez, Katia
AU  - Sanchez Gonzalez K
AD  - Southern Counties Veterinary Specialists, Forest Corner Farm, Hangersley, 
      Ringwood BH24 3JW, UK.
FAU - Marrington, Mary
AU  - Marrington M
AD  - Northwest Veterinary Specialists, Part of Linnaeus Veterinary Limited, Ashville 
      Point, Beechwood, Sutton Weaver, Runcorn WA7 3FW, UK.
FAU - Grant, Jessica
AU  - Grant J
AD  - Northwest Veterinary Specialists, Part of Linnaeus Veterinary Limited, Ashville 
      Point, Beechwood, Sutton Weaver, Runcorn WA7 3FW, UK.
LA  - eng
PT  - Journal Article
DEP - 20230821
PL  - Switzerland
TA  - Vet Sci
JT  - Veterinary sciences
JID - 101680127
PMC - PMC10458788
OTO - NOTNLM
OT  - COX inhibitor
OT  - bladder cancer
OT  - canine
OT  - chemotherapy
OT  - oncology
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2023/08/25 12:43
MHDA- 2023/08/25 12:44
PMCR- 2023/08/21
CRDT- 2023/08/25 10:44
PHST- 2023/06/08 00:00 [received]
PHST- 2023/08/14 00:00 [revised]
PHST- 2023/08/16 00:00 [accepted]
PHST- 2023/08/25 12:44 [medline]
PHST- 2023/08/25 12:43 [pubmed]
PHST- 2023/08/25 10:44 [entrez]
PHST- 2023/08/21 00:00 [pmc-release]
AID - vetsci10080529 [pii]
AID - vetsci-10-00529 [pii]
AID - 10.3390/vetsci10080529 [doi]
PST - epublish
SO  - Vet Sci. 2023 Aug 21;10(8):529. doi: 10.3390/vetsci10080529.