PMID- 37625216
OWN - NLM
STAT- MEDLINE
DCOM- 20231114
LR  - 20231122
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 116
DP  - 2024 Jan
TI  - Self-directed physical activity interventions for motor symptoms and quality of 
      life in early and mid-stage Parkinson's disease: A systematic review and 
      meta-analysis.
PG  - 105159
LID - S0167-4943(23)00237-6 [pii]
LID - 10.1016/j.archger.2023.105159 [doi]
AB  - BACKGROUND: Self-directed physical activity (SDPA) has been found in previous 
      research to alleviate some of the symptoms of early and mid-stage Parkinson's 
      disease (PD) patients. So, this study aimed to determine the impact of SDPA on 
      these patients in the areas of motor symptoms, and quality of life (QoL). METHOD: 
      PubMed, Embase, the Cochrane Library, the Web of Science, Scopus, and ProQuest 
      were all searched. The risk-of-bias tool of Cochrane for randomized trials, 
      Version 2 (RoB 2), was also used to assess the credibility of studies in terms of 
      their procedures. RESULTS: 15 eligible studies were analyzed. SDPA improved motor 
      function and mobility, including timed up and go (TUG) test [standardized mean 
      difference (SMD), -0.55 (95% CI, -0.91 - -0.18), p = 0.003], 6-minute walking 
      (6MW) test [1.11 (0.75 - 1.47), p < 0.00001], stride length [0.45 (0.18 - 0.72), 
      p = 0.001], gait velocity [0.42 (0.04 - 0.81 p = 0.03], Unified Parkinson's 
      Disease Rating Scale Part-III (UPDRS-III) [-0.76 (-1.18 - -0.33), p = 0.0005] and 
      enhanced Berg Balance Scale (BBS) [0.88 (0.50 - 1.27), p < 0.00001]). Despite 
      engaging in SDPA, there was no significant improvement observed in freezing of 
      gait (FOG) [0.23 (-0.11 - 0.56), p = 0.18] as well as the Parkinson's Disease 
      Questionnaire-39 (PDQ-39) [0.04 (-0.55 - 0.62), p = 0.90]). CONCLUSION: The motor 
      symptoms of those with early to mid-stage PD improved with SDPA, however the 
      research found no enhancement in FOG or QoL.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Li, Hanzhang
AU  - Li H
AD  - Hubei University of Chinese Medicine, Wuhan, China.
FAU - Cao, Chunhao
AU  - Cao C
AD  - Department of Integrated Traditional Chinese and Western Medicine, The First 
      Affiliate Hospital of Chongqing Medical University, Chongqing, China.
FAU - Li, Yanan
AU  - Li Y
AD  - Hubei University of Chinese Medicine, Wuhan, China. Electronic address: 
      yananlil150@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20230813
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
SB  - IM
MH  - Humans
MH  - Quality of Life
MH  - *Parkinson Disease
MH  - *Gait Disorders, Neurologic
MH  - Exercise
MH  - Walking
OTO - NOTNLM
OT  - Meta-analysis
OT  - Motor symptoms
OT  - Parkinson's disease
OT  - Quality of life
OT  - Self-directed physical activity
OT  - Systematic review
COIS- Declaration of Competing Interest None.
EDAT- 2023/08/26 05:41
MHDA- 2023/11/14 06:43
CRDT- 2023/08/25 18:02
PHST- 2023/07/10 00:00 [received]
PHST- 2023/07/31 00:00 [revised]
PHST- 2023/08/11 00:00 [accepted]
PHST- 2023/11/14 06:43 [medline]
PHST- 2023/08/26 05:41 [pubmed]
PHST- 2023/08/25 18:02 [entrez]
AID - S0167-4943(23)00237-6 [pii]
AID - 10.1016/j.archger.2023.105159 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2024 Jan;116:105159. doi: 10.1016/j.archger.2023.105159. 
      Epub 2023 Aug 13.