PMID- 37626171
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20231119
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 14
IP  - 1
DP  - 2023 Aug 25
TI  - A frontal transcallosal inhibition loop mediates interhemispheric balance in 
      visuospatial processing.
PG  - 5213
LID - 10.1038/s41467-023-40985-5 [doi]
LID - 5213
AB  - Interhemispheric communication through the corpus callosum is required for both 
      sensory and cognitive processes. Impaired transcallosal inhibition causing 
      interhemispheric imbalance is believed to underlie visuospatial bias after 
      frontoparietal cortical damage, but the synaptic circuits involved remain largely 
      unknown. Here, we show that lesions in the mouse anterior cingulate area (ACA) 
      cause severe visuospatial bias mediated by a transcallosal inhibition loop. In a 
      visual-change-detection task, ACA callosal-projection neurons (CPNs) were more 
      active with contralateral visual field changes than with ipsilateral changes. 
      Unilateral CPN inactivation impaired contralateral change detection but improved 
      ipsilateral detection by altering interhemispheric interaction through callosal 
      projections. CPNs strongly activated contralateral parvalbumin-positive (PV+) 
      neurons, and callosal-input-driven PV+ neurons preferentially inhibited 
      ipsilateral CPNs, thus mediating transcallosal inhibition. Unilateral PV+ neuron 
      activation caused a similar behavioral bias to contralateral CPN activation and 
      ipsilateral CPN inactivation, and bilateral PV+ neuron activation eliminated this 
      bias. Notably, restoring interhemispheric balance by activating contralesional 
      PV+ neurons significantly improved contralesional detection in ACA-lesioned 
      animals. Thus, a frontal transcallosal inhibition loop comprising CPNs and 
      callosal-input-driven PV+ neurons mediates interhemispheric balance in 
      visuospatial processing, and enhancing contralesional transcallosal inhibition 
      restores interhemispheric balance while also reversing lesion-induced bias.
CI  - (c) 2023. Springer Nature Limited.
FAU - Wang, Yanjie
AU  - Wang Y
AD  - Songjiang Research Institute, Shanghai Songjiang District Central Hospital, 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.
AD  - Center for Brain Science of Shanghai Children's Medical Center, Department of 
      Anatomy and Physiology, School of Medicine, Shanghai Jiao Tong University, 
      Shanghai, 200127, China.
FAU - Chen, Zhaonan
AU  - Chen Z
AD  - Songjiang Research Institute, Shanghai Songjiang District Central Hospital, 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.
AD  - Center for Brain Science of Shanghai Children's Medical Center, Department of 
      Anatomy and Physiology, School of Medicine, Shanghai Jiao Tong University, 
      Shanghai, 200127, China.
FAU - Ma, Guofen
AU  - Ma G
AD  - Songjiang Research Institute, Shanghai Songjiang District Central Hospital, 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.
AD  - Center for Brain Science of Shanghai Children's Medical Center, Department of 
      Anatomy and Physiology, School of Medicine, Shanghai Jiao Tong University, 
      Shanghai, 200127, China.
FAU - Wang, Lizhao
AU  - Wang L
AD  - Songjiang Research Institute, Shanghai Songjiang District Central Hospital, 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.
AD  - Center for Brain Science of Shanghai Children's Medical Center, Department of 
      Anatomy and Physiology, School of Medicine, Shanghai Jiao Tong University, 
      Shanghai, 200127, China.
FAU - Liu, Yanmei
AU  - Liu Y
AD  - Songjiang Research Institute, Shanghai Songjiang District Central Hospital, 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.
AD  - Center for Brain Science of Shanghai Children's Medical Center, Department of 
      Anatomy and Physiology, School of Medicine, Shanghai Jiao Tong University, 
      Shanghai, 200127, China.
FAU - Qin, Meiling
AU  - Qin M
AD  - Institute of Neuroscience, CAS Center for Excellence in Brain Science and 
      Intelligence Technology, State Key Laboratory of Neuroscience, Chinese Academy of 
      Sciences, Shanghai, 200031, China.
FAU - Fei, Xiang
AU  - Fei X
AD  - Institute of Neuroscience, CAS Center for Excellence in Brain Science and 
      Intelligence Technology, State Key Laboratory of Neuroscience, Chinese Academy of 
      Sciences, Shanghai, 200031, China.
FAU - Wu, Yifan
AU  - Wu Y
AUID- ORCID: 0009-0000-2032-6719
AD  - Songjiang Research Institute, Shanghai Songjiang District Central Hospital, 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.
AD  - Center for Brain Science of Shanghai Children's Medical Center, Department of 
      Anatomy and Physiology, School of Medicine, Shanghai Jiao Tong University, 
      Shanghai, 200127, China.
FAU - Xu, Min
AU  - Xu M
AUID- ORCID: 0000-0002-6936-7543
AD  - Institute of Neuroscience, CAS Center for Excellence in Brain Science and 
      Intelligence Technology, State Key Laboratory of Neuroscience, Chinese Academy of 
      Sciences, Shanghai, 200031, China. mxu@ion.ac.cn.
FAU - Zhang, Siyu
AU  - Zhang S
AUID- ORCID: 0000-0003-1745-2532
AD  - Songjiang Research Institute, Shanghai Songjiang District Central Hospital, 
      Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China. 
      zhang_siyu@sjtu.edu.cn.
AD  - Center for Brain Science of Shanghai Children's Medical Center, Department of 
      Anatomy and Physiology, School of Medicine, Shanghai Jiao Tong University, 
      Shanghai, 200127, China. zhang_siyu@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230825
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 0 (Parvalbumins)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Inhibition, Psychological
MH  - *Interneurons
MH  - Neurons
MH  - Corpus Callosum
MH  - Parvalbumins
PMC - PMC10457336
COIS- The authors declare no competing interests.
EDAT- 2023/08/26 05:41
MHDA- 2023/08/28 06:42
PMCR- 2023/08/25
CRDT- 2023/08/25 23:28
PHST- 2023/01/31 00:00 [received]
PHST- 2023/08/17 00:00 [accepted]
PHST- 2023/08/28 06:42 [medline]
PHST- 2023/08/26 05:41 [pubmed]
PHST- 2023/08/25 23:28 [entrez]
PHST- 2023/08/25 00:00 [pmc-release]
AID - 10.1038/s41467-023-40985-5 [pii]
AID - 40985 [pii]
AID - 10.1038/s41467-023-40985-5 [doi]
PST - epublish
SO  - Nat Commun. 2023 Aug 25;14(1):5213. doi: 10.1038/s41467-023-40985-5.