PMID- 37627526
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230828
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 12
IP  - 8
DP  - 2023 Jul 30
TI  - Voluntary Exercise-Mediated Protection in TNBS-Induced Rat Colitis: The 
      Involvement of NETosis and Prdx Antioxidants.
LID - 10.3390/antiox12081531 [doi]
LID - 1531
AB  - Inflammatory bowel diseases (IBDs) are autoimmune disorders of the gut. It is 
      increasingly clear that voluntary exercise (VE) may exert protection against 
      IBDs, but the exact background mechanism needs to be elucidated. In the present 
      study, we aimed to investigate the possible role of NETosis and the antioxidant 
      peroxiredoxin (Prdx) enzyme family in VE-induced protection. Wistar Han rats were 
      randomly divided into two groups: sedentary (SED) and VE. After the 6-week 
      voluntary wheel running, animals were treated with 2,4,6-trinitrobenzene 
      sulphonic acid (TNBS) as a model of colitis. Here, we found that VE significantly 
      decreased inflammation and ulceration of the colon in the VE TNBS group compared 
      with SED TNBS. We also found that VE significantly decreased the expression of 
      protein arginine deiminase 4 (PAD4) and myeloperoxidase (MPO), and markedly 
      reduced citrullinated histone H3 (citH3) compared with SED TNBS. Furthermore, VE 
      caused a significant increase in the levels of Prdx6 in the control and TNBS 
      groups. Taken together, we found that a prior 6-week VE effectively reduces 
      inflammation in TNBS-induced colitis, and we suggest that the protective effect 
      of VE may be mediated via the inhibition of NETosis and upregulation of Prdx6 
      antioxidant.
FAU - Almasi, Nikoletta
AU  - Almasi N
AD  - Department of Physiology, Anatomy and Neuroscience, University of Szeged, H-6726 
      Szeged, Hungary.
FAU - Torok, Szilvia
AU  - Torok S
AD  - Department of Physiology, Anatomy and Neuroscience, University of Szeged, H-6726 
      Szeged, Hungary.
FAU - Al-Awar, Amin
AU  - Al-Awar A
AD  - Department of Physiology, Anatomy and Neuroscience, University of Szeged, H-6726 
      Szeged, Hungary.
FAU - Veszelka, Medea
AU  - Veszelka M
AD  - Department of Physiology, Anatomy and Neuroscience, University of Szeged, H-6726 
      Szeged, Hungary.
FAU - Kiraly, Laszlo
AU  - Kiraly L
AD  - Zala-Cerealia Kft, H-8790 Zalaszentgrot-Tuskeszentpeter, Hungary.
FAU - Borzsei, Denise
AU  - Borzsei D
AD  - Department of Physiology, Anatomy and Neuroscience, University of Szeged, H-6726 
      Szeged, Hungary.
FAU - Szabo, Renata
AU  - Szabo R
AD  - Department of Physiology, Anatomy and Neuroscience, University of Szeged, H-6726 
      Szeged, Hungary.
FAU - Varga, Csaba
AU  - Varga C
AD  - Department of Physiology, Anatomy and Neuroscience, University of Szeged, H-6726 
      Szeged, Hungary.
LA  - eng
PT  - Journal Article
DEP - 20230730
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC10451893
OTO - NOTNLM
OT  - IBDS
OT  - inflammation
OT  - peroxiredoxin
OT  - voluntary exercise
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/26 10:47
MHDA- 2023/08/26 10:48
PMCR- 2023/07/30
CRDT- 2023/08/26 01:06
PHST- 2023/07/08 00:00 [received]
PHST- 2023/07/27 00:00 [revised]
PHST- 2023/07/29 00:00 [accepted]
PHST- 2023/08/26 10:48 [medline]
PHST- 2023/08/26 10:47 [pubmed]
PHST- 2023/08/26 01:06 [entrez]
PHST- 2023/07/30 00:00 [pmc-release]
AID - antiox12081531 [pii]
AID - antioxidants-12-01531 [pii]
AID - 10.3390/antiox12081531 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2023 Jul 30;12(8):1531. doi: 10.3390/antiox12081531.