PMID- 37627999
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230828
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 12
IP  - 16
DP  - 2023 Aug 9
TI  - Investigation of the Potential Phlorotannins and Mechanism of Six Brown Algae in 
      Treating Type II Diabetes Mellitus Based on Biological Activity, UPLC-QE-MS/MS, 
      and Network Pharmacology.
LID - 10.3390/foods12163000 [doi]
LID - 3000
AB  - Type 2 diabetes mellitus (T2DM) has developed into an important health concern 
      worldwide. The discovery of phlorotannins and their efficacy in the treatment of 
      T2DM has become a hotspot for research in various fields. In this study, the 
      potential phlorotannins and mechanism of six brown algae against T2DM were 
      in-depth investigated using biological activity assays, LC-MS, and network 
      pharmacology. First, the ethyl acetate fraction (EA frac.) showed high 
      polyphenolic content and possessed significantly antioxidant and enzyme 
      inhibitory abilities. Further, a total of fifty-nine peaks were obtained from six 
      EA fracs. via UPLC-QE-MS/MS analysis, and fifteen of them were identified as 
      phlorotannins and their isomers or derivatives. In detail, the chemical 
      structures of six phlorotannins were inferred as dibenzodioxine-1,3,6,8-tetraol, 
      bifuhalol, dioxinodehydroeckol, eckol, fucofurodiphlorethol, and 
      fucotriphlorethol; three phlorotannin isomers were deduced to be fucophlorethol, 
      trifucol, triphlorethol A, or triphlorethol B; and the phlorotannin derivative of 
      m/z 263 was determined to be dibenzodioxine-1,2,3,6,8-pentanol or 
      dibenzodioxine-1,2,4,5,7-pentanol. Moreover, 43 T2DM-related targets acted on by 
      these chemicals were identified, and the function of phlorotannin to prevent and 
      treat T2DM was elucidated in a holistic way based on the established 
      compound-target-disease network, and GO function and KEGG pathway enrichment 
      analysis.
FAU - Chen, Jialiang
AU  - Chen J
AD  - School of Food Science and Technology, Dalian Polytechnic University, Dalian 
      116034, China.
FAU - Zhou, Zheng
AU  - Zhou Z
AD  - National Engineering Research Center of Seafood, School of Food Science and 
      Technology, Dalian Polytechnic University, Dalian 116034, China.
FAU - Li, Ping
AU  - Li P
AD  - School of Food Science and Technology, Dalian Polytechnic University, Dalian 
      116034, China.
FAU - Ye, Shuhong
AU  - Ye S
AD  - School of Food Science and Technology, Dalian Polytechnic University, Dalian 
      116034, China.
FAU - Li, Wei
AU  - Li W
AUID- ORCID: 0000-0001-7272-7290
AD  - Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 
      Daegu 41062, Republic of Korea.
FAU - Li, Ming
AU  - Li M
AD  - College of Basic Medical Science, Dalian Medical University, Dalian 116044, 
      China.
FAU - Zhu, Lin
AU  - Zhu L
AD  - School of Food Science and Technology, Dalian Polytechnic University, Dalian 
      116034, China.
FAU - Ding, Yan
AU  - Ding Y
AUID- ORCID: 0000-0001-8431-7694
AD  - School of Food Science and Technology, Dalian Polytechnic University, Dalian 
      116034, China.
LA  - eng
GR  - 2021-MS-299/Natural Science Foundation of Liaoning Province/
GR  - 31770725/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20230809
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC10453309
OTO - NOTNLM
OT  - T2DM
OT  - UPLC-QE-MS/MS
OT  - network pharmacology
OT  - phlorotannins
COIS- The authors declare that they have no conflict of interest in this paper.
EDAT- 2023/08/26 10:46
MHDA- 2023/08/26 10:47
PMCR- 2023/08/09
CRDT- 2023/08/26 01:09
PHST- 2023/06/18 00:00 [received]
PHST- 2023/07/14 00:00 [revised]
PHST- 2023/07/29 00:00 [accepted]
PHST- 2023/08/26 10:47 [medline]
PHST- 2023/08/26 10:46 [pubmed]
PHST- 2023/08/26 01:09 [entrez]
PHST- 2023/08/09 00:00 [pmc-release]
AID - foods12163000 [pii]
AID - foods-12-03000 [pii]
AID - 10.3390/foods12163000 [doi]
PST - epublish
SO  - Foods. 2023 Aug 9;12(16):3000. doi: 10.3390/foods12163000.