PMID- 37628555
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231102
IS  - 2227-9032 (Print)
IS  - 2227-9032 (Electronic)
IS  - 2227-9032 (Linking)
VI  - 11
IP  - 16
DP  - 2023 Aug 21
TI  - Dose-Response Relationship between Gestational Weight Gain and Neonatal 
      Birthweight in Chinese Women with Excess Weight/Obesity and Gestational Diabetes 
      Mellitus.
LID - 10.3390/healthcare11162358 [doi]
LID - 2358
AB  - Total gestational weight gain (GWG) is identified as a strong and potentially 
      controllable predictor of long-term health outcomes in women with gestational 
      diabetes mellitus (GDM) and infants. When the total GWG of women with excess 
      weight/obesity and GDM does not exceed the Institute of Medicine (IOM) suggested 
      range, neonatal birthweight outcomes may be favorable, but the evidence is 
      limited. Therefore, the objective of this study was to evaluate the dose-response 
      relationship between increased total GWG and the risk of neonatal birthweight in 
      Chinese women with excess weight/obesity and GDM. This study obtained electronic 
      medical records (EMR) from the hospital information system (HIS) of the Chongqing 
      Health Center for Women and Children between July 2017, and June 2020. A 
      retrospective study analyzed the effect of the total GWG of women with excess 
      weight/obesity and GDM on neonatal birthweight. The dose-response relationship 
      between total GWG and neonatal birthweight was studied using a generalized linear 
      model and embedded restricted cubic splines (RCS). The average age of all women 
      with GDM was 31.99 +/- 4.47 years, and 27.61% were advanced maternal age (>/=35 
      years). The total GWG among women with excess weight and obesity and GDM greater 
      than the IOM recommendations were found in 42.96% and 58.62% of cases, 
      respectively. Total GWG in women with excess weight and excessing the IOM 
      recommended range is a risk factor for large gestational age (LGA) [adjusted odds 
      ratio (aOR) 0.1.47, 1.08-2.01] and macrosomia (aOR 1.55, 1.04-2.31). In the 
      obesity above group, excessive weight gain increased the risk of LGA (aOR 2.92, 
      1.33-6.41) and macrosomia (aOR 2.83, 1.03-7.72). We used an RCS to examine 
      pregnant women with excess weight and GDM and discovered a linear dose-response 
      relationship between total GWG and LGA/macrosomia. In women with excess weight 
      and obesity, increases in total GWG above the lowest end of the IOM 
      recommendations range (7 kg and 5 kg) were associated with an increased risk of 
      LGA and macrosomia. Therefore, research is urgently needed to support maternal 
      and newborn health to provide recommendations for the ideal weight increase in 
      women with excess weight/obesity and GDM.
FAU - He, Jing
AU  - He J
AUID- ORCID: 0000-0001-7654-1872
AD  - Nursing Department, Tongji Hospital of Tongji Medical College of Huazhong 
      University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China.
AD  - School of Nursing, Tongji Medical College of Huazhong University of Science and 
      Technology, 13 Hangkong Road, Wuhan 430030, China.
FAU - Hu, Kaili
AU  - Hu K
AD  - Nursing Department, Tongji Hospital of Tongji Medical College of Huazhong 
      University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China.
FAU - Wang, Binghua
AU  - Wang B
AD  - Nursing Department, Tongji Hospital of Tongji Medical College of Huazhong 
      University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China.
FAU - Chen, Zhen
AU  - Chen Z
AD  - Department of Gynaecology and Obstetrics, Chongqing Health Center for Women and 
      Children (Women and Children's Hospital of Chongqing Medical University), 120 
      Longshan Road, Chongqing 401147, China.
FAU - Wang, Hui
AU  - Wang H
AD  - Nursing Department, Tongji Hospital of Tongji Medical College of Huazhong 
      University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China.
LA  - eng
GR  - 2022C06/the Research Major Project for Tongji Hospital of Tongji Medical College 
      of Huazhong University of Science and Technology/
GR  - WHHL202201/Wuhan Nursing Association in China/
PT  - Journal Article
DEP - 20230821
PL  - Switzerland
TA  - Healthcare (Basel)
JT  - Healthcare (Basel, Switzerland)
JID - 101666525
PMC - PMC10454079
OTO - NOTNLM
OT  - China
OT  - gestational diabetes mellitus
OT  - gestational weight gain
OT  - neonatal birthweight
OT  - obesity
OT  - overweight
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/26 10:44
MHDA- 2023/08/26 10:45
PMCR- 2023/08/21
CRDT- 2023/08/26 01:12
PHST- 2023/06/23 00:00 [received]
PHST- 2023/08/10 00:00 [revised]
PHST- 2023/08/13 00:00 [accepted]
PHST- 2023/08/26 10:45 [medline]
PHST- 2023/08/26 10:44 [pubmed]
PHST- 2023/08/26 01:12 [entrez]
PHST- 2023/08/21 00:00 [pmc-release]
AID - healthcare11162358 [pii]
AID - healthcare-11-02358 [pii]
AID - 10.3390/healthcare11162358 [doi]
PST - epublish
SO  - Healthcare (Basel). 2023 Aug 21;11(16):2358. doi: 10.3390/healthcare11162358.