PMID- 37628795
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20230829
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 16
DP  - 2023 Aug 9
TI  - Taxifolin Reduces Blood Pressure via Improvement of Vascular Function and 
      Mitigating the Vascular Inflammatory Response in Spontaneously Hypertensive Rats.
LID - 10.3390/ijms241612616 [doi]
LID - 12616
AB  - The effect of a 10-day-long treatment with taxifolin (TAX, 20 mg/kg/day p.o.) was 
      investigated on spontaneously hypertensive rats (SHRs) with a focus on the 
      vascular functions of isolated femoral arteries and thoracic aortas. TAX reduced 
      blood pressure in SHRs. In femoral arteries, TAX increased acetylcholine-induced 
      relaxation, reduced the maximal NA-induced contraction, and reduced 
      acetylcholine-induced endothelium-dependent contraction (EDC); however, TAX had 
      no effect on the vascular reactivity of isolated thoracic aortas. In addition, 
      TAX elevated the total nitric oxide synthase (NOS) activity and iNOS protein 
      expression but reduced cyclooxygenase-2 (COX2) protein expression in the tissue 
      of the abdominal aorta without changes in Nos2 and Ptgs2 gene expressions. TAX 
      also increased the gene expression of the anti-inflammatory interleukin-10 
      (Il10). In addition, in vitro studies showed that TAX has both electron donor and 
      H atom donor properties. However, TAX failed to reduce superoxide production in 
      the tissue of the abdominal aorta after oral administration. In conclusion, our 
      results show that a decrease in the blood pressure in TAX-treated SHRs might be 
      attributed to improved endothelium-dependent relaxation and reduced 
      endothelium-dependent contraction. In addition, the results suggest that the 
      effect of TAX on blood pressure regulation also involves the attenuation of 
      COX2-mediated pro-inflammation and elevation of anti-inflammatory pathways.
FAU - Liskova, Silvia
AU  - Liskova S
AUID- ORCID: 0000-0003-4417-4232
AD  - Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal 
      and Pathological Physiology, Sienkiewiczova 1, 813 71 Bratislava, Slovakia.
AD  - Faculty of Medicine, Institute of Pharmacology and Clinical Pharmacology, 
      Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia.
FAU - Cacanyiova, Sona
AU  - Cacanyiova S
AUID- ORCID: 0000-0003-0483-7468
AD  - Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal 
      and Pathological Physiology, Sienkiewiczova 1, 813 71 Bratislava, Slovakia.
FAU - Cebova, Martina
AU  - Cebova M
AUID- ORCID: 0000-0003-0132-670X
AD  - Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal 
      and Pathological Physiology, Sienkiewiczova 1, 813 71 Bratislava, Slovakia.
FAU - Berenyiova, Andrea
AU  - Berenyiova A
AUID- ORCID: 0000-0003-3108-238X
AD  - Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal 
      and Pathological Physiology, Sienkiewiczova 1, 813 71 Bratislava, Slovakia.
FAU - Kluknavsky, Michal
AU  - Kluknavsky M
AD  - Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal 
      and Pathological Physiology, Sienkiewiczova 1, 813 71 Bratislava, Slovakia.
FAU - Micurova, Andrea
AU  - Micurova A
AD  - Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal 
      and Pathological Physiology, Sienkiewiczova 1, 813 71 Bratislava, Slovakia.
FAU - Valachova, Katarina
AU  - Valachova K
AUID- ORCID: 0000-0002-8467-893X
AD  - Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of 
      Experimental Pharmacology and Toxicology, Dubravska cesta 9, 841 04 Bratislava, 
      Slovakia.
FAU - Soltes, Ladislav
AU  - Soltes L
AD  - Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of 
      Experimental Pharmacology and Toxicology, Dubravska cesta 9, 841 04 Bratislava, 
      Slovakia.
FAU - Bernatova, Iveta
AU  - Bernatova I
AUID- ORCID: 0000-0002-6120-706X
AD  - Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal 
      and Pathological Physiology, Sienkiewiczova 1, 813 71 Bratislava, Slovakia.
LA  - eng
GR  - PP-COVID-20-0043/Slovak Research and Development Agency/
GR  - 2/0157/21/Scientific Grant Agency of the Ministry of Education, Science, Research 
      and Sport of the Slovak Republic/
GR  - 2/0019/19/Scientific Grant Agency of the Ministry of Education, Science, Research 
      and Sport of the Slovak Republic/
GR  - "Vyvoj biomodelov pre zlepsenie hodnotenia ucinnosti liekov a latok, ktore maju 
      potencial pri liecbe COVID-19 (BIOVID- 19)" - ITMS2014+: 313011AVG3/European 
      Regional Development Fund/
PT  - Journal Article
DEP - 20230809
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 9SOB9E3987 (taxifolin)
RN  - N9YNS0M02X (Acetylcholine)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Animals
MH  - Rats
MH  - Blood Pressure
MH  - Rats, Inbred SHR
MH  - *Acetylcholine
MH  - Cyclooxygenase 2/genetics
PMC - PMC10454553
OTO - NOTNLM
OT  - dihydroquercetin
OT  - isolated femoral artery
OT  - isolated thoracic aorta
OT  - spontaneously hypertensive rats
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/26 10:43
MHDA- 2023/08/28 07:16
PMCR- 2023/08/09
CRDT- 2023/08/26 01:14
PHST- 2023/06/29 00:00 [received]
PHST- 2023/07/24 00:00 [revised]
PHST- 2023/08/06 00:00 [accepted]
PHST- 2023/08/28 07:16 [medline]
PHST- 2023/08/26 10:43 [pubmed]
PHST- 2023/08/26 01:14 [entrez]
PHST- 2023/08/09 00:00 [pmc-release]
AID - ijms241612616 [pii]
AID - ijms-24-12616 [pii]
AID - 10.3390/ijms241612616 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Aug 9;24(16):12616. doi: 10.3390/ijms241612616.