PMID- 37628917
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20230829
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 16
DP  - 2023 Aug 13
TI  - Signaling Pathways Leading to mTOR Activation Downstream Cytokine Receptors in 
      Lymphocytes in Health and Disease.
LID - 10.3390/ijms241612736 [doi]
LID - 12736
AB  - CD8+ T cells and Natural Killer (NK) cells are cytotoxic lymphocytes important in 
      the response to intracellular pathogens and cancer. Their activity depends on the 
      integration of a large set of intracellular and environmental cues, including 
      antigenic signals, cytokine stimulation and nutrient availability. This 
      integration is achieved by signaling hubs, such as the mechanistic target of 
      rapamycin (mTOR). mTOR is a conserved protein kinase that controls cellular 
      growth and metabolism in eukaryotic cells and, therefore, is essential for 
      lymphocyte development and maturation. However, our current understanding of mTOR 
      signaling comes mostly from studies performed in transformed cell lines, which 
      constitute a poor model for comprehending metabolic pathway regulation. 
      Therefore, it is only quite recently that the regulation of mTOR in primary cells 
      has been assessed. Here, we review the signaling pathways leading to mTOR 
      activation in CD8+ T and NK cells, focusing on activation by cytokines. We also 
      discuss how this knowledge can contribute to immunotherapy development, 
      particularly for cancer treatment.
FAU - Fallone, Lucie
AU  - Fallone L
AD  - CIRI-Centre International de Recherche en Infectiologie (Team Lyacts), Inserm, 
      U1111, Universite Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007 
      Lyon, France.
FAU - Walzer, Thierry
AU  - Walzer T
AD  - CIRI-Centre International de Recherche en Infectiologie (Team Lyacts), Inserm, 
      U1111, Universite Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007 
      Lyon, France.
FAU - Marcais, Antoine
AU  - Marcais A
AD  - CIRI-Centre International de Recherche en Infectiologie (Team Lyacts), Inserm, 
      U1111, Universite Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007 
      Lyon, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230813
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - 0 (Cytokines)
SB  - IM
MH  - *TOR Serine-Threonine Kinases
MH  - *Signal Transduction
MH  - Killer Cells, Natural
MH  - CD8-Positive T-Lymphocytes
MH  - Cell Cycle
MH  - Cytokines
PMC - PMC10454121
OTO - NOTNLM
OT  - CD8+ T cell
OT  - NK cell
OT  - cytokine signaling
OT  - mTOR
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/26 10:46
MHDA- 2023/08/28 07:16
PMCR- 2023/08/13
CRDT- 2023/08/26 01:15
PHST- 2023/06/12 00:00 [received]
PHST- 2023/08/09 00:00 [revised]
PHST- 2023/08/10 00:00 [accepted]
PHST- 2023/08/28 07:16 [medline]
PHST- 2023/08/26 10:46 [pubmed]
PHST- 2023/08/26 01:15 [entrez]
PHST- 2023/08/13 00:00 [pmc-release]
AID - ijms241612736 [pii]
AID - ijms-24-12736 [pii]
AID - 10.3390/ijms241612736 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Aug 13;24(16):12736. doi: 10.3390/ijms241612736.