PMID- 37629093
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20230829
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 16
DP  - 2023 Aug 18
TI  - Updates on Larynx Cancer: Risk Factors and Oncogenesis.
LID - 10.3390/ijms241612913 [doi]
LID - 12913
AB  - Laryngeal cancer is a very common tumor in the upper aero-digestive tract. 
      Understanding its biological mechanisms has garnered significant interest in 
      recent years. The development of laryngeal squamous cell carcinoma (LSCC) follows 
      a multistep process starting from precursor lesions in the epithelium. Various 
      risk factors have been associated with laryngeal tumors, including smoking, 
      alcohol consumption, opium use, as well as infections with HPV and EBV viruses, 
      among others. Cancer development involves multiple steps, and genetic alterations 
      play a crucial role. Tumor suppressor genes can be inactivated, and 
      proto-oncogenes may become activated through mechanisms like deletions, point 
      mutations, promoter methylation, and gene amplification. Epigenetic 
      modifications, driven by miRNAs, have been proven to contribute to LSCC 
      development. Despite advances in molecular medicine, there are still aspects of 
      laryngeal cancer that remain poorly understood, and the underlying biological 
      mechanisms have not been fully elucidated. In this narrative review, we examined 
      the literature to analyze and summarize the main steps of carcinogenesis and the 
      risk factors associated with laryngeal cancer.
FAU - Liberale, Carlotta
AU  - Liberale C
AD  - Unit of Otorhinolaryngology, Head & Neck Department, University of Verona, 
      Piazzale L.A. Scuro 10, 37134 Verona, Italy.
FAU - Soloperto, Davide
AU  - Soloperto D
AD  - Unit of Otorhinolaryngology, Head & Neck Department, University of Verona, 
      Piazzale L.A. Scuro 10, 37134 Verona, Italy.
FAU - Marchioni, Alessandro
AU  - Marchioni A
AUID- ORCID: 0000-0003-3720-3517
AD  - Respiratory Disease Unit, University Hospital of Modena, 41124 Modena, Italy.
FAU - Monzani, Daniele
AU  - Monzani D
AD  - Unit of Otorhinolaryngology, Head & Neck Department, University of Verona, 
      Piazzale L.A. Scuro 10, 37134 Verona, Italy.
FAU - Sacchetto, Luca
AU  - Sacchetto L
AD  - Unit of Otorhinolaryngology, Head & Neck Department, University of Verona, 
      Piazzale L.A. Scuro 10, 37134 Verona, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230818
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Humans
MH  - *Laryngeal Neoplasms/genetics
MH  - Carcinogenesis/genetics
MH  - Cell Transformation, Neoplastic
MH  - Risk Factors
MH  - Alcohol Drinking/adverse effects
PMC - PMC10454133
OTO - NOTNLM
OT  - larynx cancer
OT  - oncogenesis
OT  - risk factors
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/26 10:46
MHDA- 2023/08/28 07:16
PMCR- 2023/08/18
CRDT- 2023/08/26 01:16
PHST- 2023/07/27 00:00 [received]
PHST- 2023/08/14 00:00 [revised]
PHST- 2023/08/15 00:00 [accepted]
PHST- 2023/08/28 07:16 [medline]
PHST- 2023/08/26 10:46 [pubmed]
PHST- 2023/08/26 01:16 [entrez]
PHST- 2023/08/18 00:00 [pmc-release]
AID - ijms241612913 [pii]
AID - ijms-24-12913 [pii]
AID - 10.3390/ijms241612913 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Aug 18;24(16):12913. doi: 10.3390/ijms241612913.