PMID- 37629262 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230829 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 12 IP - 16 DP - 2023 Aug 10 TI - Impact of Advanced Age on the Incidence of Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stable Coronary Artery Disease in a Real-World Setting in Spain. LID - 10.3390/jcm12165218 [doi] LID - 5218 AB - Patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) without myocardial infarction (MI) or stroke are at high risk for major cardiovascular events (MACEs). We aimed to provide real-world data on age-related clinical characteristics, treatment management, and incidence of major cardiovascular outcomes in T2DM-CAD patients in Spain from 2014 to 2018. We used EHRead((R)) technology, which is based on natural language processing and machine learning, to extract unstructured clinical information from electronic health records (EHRs) from 12 hospitals. Of the 4072 included patients, 30.9% were younger than 65 years (66.3% male), 34.2% were aged 65-75 years (66.4% male), and 34.8% were older than 75 years (54.3% male). These older patients were more likely to have hypertension (OR 2.85), angina (OR 1.64), heart valve disease (OR 2.13), or peripheral vascular disease (OR 2.38) than those aged <65 years (p < 0.001 for all comparisons). In general, they were also more likely to receive pharmacological and interventional treatments. Moreover, these patients had a significantly higher risk of MACEs (HR 1.29; p = 0.003) and ischemic stroke (HR 2.39; p < 0.001). In summary, patients with T2DM-CAD in routine clinical practice tend to be older, have more comorbidities, are more heavily treated, and have a higher risk of developing MACE than is commonly assumed from clinical trial data. FAU - Gonzalez-Juanatey, Carlos AU - Gonzalez-Juanatey C AUID- ORCID: 0000-0002-4483-9778 AD - Hospital Universitario Lucus Augusti, 27003 Lugo, Spain. FAU - Anguita-Sanchez, Manuel AU - Anguita-Sanchez M AD - Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Hospital Universitario Reina Sofia, Universidad de Cordoba, 14014 Cordoba, Spain. FAU - Barrios, Vivencio AU - Barrios V AUID- ORCID: 0000-0001-6135-7685 AD - Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain. FAU - Nunez-Gil, Ivan AU - Nunez-Gil I AUID- ORCID: 0000-0002-1779-3102 AD - Cardiology Department, Hospital Clinico Universitario San Carlos, 28040 Madrid, Spain. AD - Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odon, 28670 Madrid, Spain. FAU - Gomez-Doblas, Juan Jose AU - Gomez-Doblas JJ AUID- ORCID: 0000-0002-9020-639X AD - IBIMA (Instituto de Investigacion Biomedica de Malaga), Hospital Universitario Virgen de la Victoria, CIBERCV (Centro de Investigacion Biomedica en Red Enfermedades Cardiovasculares), 29010 Malaga, Spain. FAU - Garcia-Moll, Xavier AU - Garcia-Moll X AUID- ORCID: 0000-0001-7837-8378 AD - Hospital Universitario Santa Creu i Sant Pau, 08041 Barcelona, Spain. FAU - Lafuente-Gormaz, Carlos AU - Lafuente-Gormaz C AD - Hospital Universitario de Albacete, 02006 Albacete, Spain. FAU - Rollan-Gomez, Maria Jesus AU - Rollan-Gomez MJ AD - Hospital Universitario Rio Hortega, 47012 Valladolid, Spain. FAU - Peral-Disdier, Vicente AU - Peral-Disdier V AD - Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain. FAU - Martinez-Dolz, Luis AU - Martinez-Dolz L AUID- ORCID: 0000-0001-5145-8191 AD - Hospital Universitario y Politecnico La Fe, CIBERCV (Centro de Investigacion Biomedica en Red Enfermedades Cardiovasculares), IIS La Fe, 46026 Valencia, Spain. FAU - Rodriguez-Santamarta, Miguel AU - Rodriguez-Santamarta M AD - Hospital Universitario de Leon, 24071 Leon, Spain. FAU - Vinolas-Prat, Xavier AU - Vinolas-Prat X AD - Hospital Universitario Santa Creu i Sant Pau, 08041 Barcelona, Spain. FAU - Soriano-Colome, Toni AU - Soriano-Colome T AUID- ORCID: 0000-0002-2121-6084 AD - Hospital Vall d'Hebron, CIBERCV (Centro de Investigacion Biomedica en Red Enfermedades Cardiovasculares), 08035 Barcelona, Spain. FAU - Munoz-Aguilera, Roberto AU - Munoz-Aguilera R AD - Hospital Infanta Leonor, 28031 Madrid, Spain. FAU - Plaza, Ignacio AU - Plaza I AD - Hospital Infanta Sofia, 28703 Madrid, Spain. FAU - Curcio-Ruigomez, Alejandro AU - Curcio-Ruigomez A AD - Hospital Universitario de Fuenlabrada, 28942 Madrid, Spain. FAU - Orts-Soler, Ernesto AU - Orts-Soler E AD - Hospital General Universitario de Castellon, 12004 Castellon de la Plana, Spain. FAU - Segovia-Cubero, Javier AU - Segovia-Cubero J AD - Hospital Universitario Puerta de Hierro, 28222 Madrid, Spain. FAU - Fanjul, Victor AU - Fanjul V AUID- ORCID: 0000-0003-4009-4219 AD - Savana Research SL, 28013 Madrid, Spain. FAU - Marin-Corral, Judith AU - Marin-Corral J AUID- ORCID: 0000-0003-1320-4427 AD - Savana Research SL, 28013 Madrid, Spain. FAU - Cequier, Angel AU - Cequier A AD - Hospital Universitario de Bellvitge, IDIBELL (Instituto de Investigacion Biomedica de Bellvitge), Universidad de Barcelona, 08007 Barcelona, Spain. FAU - Savana Research Group AU - Savana Research Group AD - Savana Research SL, 28013 Madrid, Spain. LA - eng GR - n.a./AstraZeneca (Spain)/ PT - Journal Article DEP - 20230810 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC10456002 OTO - NOTNLM OT - MACE OT - aging OT - coronary artery disease OT - electronic health records OT - natural language processing OT - real-world data OT - type 2 diabetes mellitus COIS- The authors declare no conflict of interest. EDAT- 2023/08/26 10:47 MHDA- 2023/08/26 10:48 PMCR- 2023/08/10 CRDT- 2023/08/26 01:18 PHST- 2023/07/04 00:00 [received] PHST- 2023/08/07 00:00 [revised] PHST- 2023/08/08 00:00 [accepted] PHST- 2023/08/26 10:48 [medline] PHST- 2023/08/26 10:47 [pubmed] PHST- 2023/08/26 01:18 [entrez] PHST- 2023/08/10 00:00 [pmc-release] AID - jcm12165218 [pii] AID - jcm-12-05218 [pii] AID - 10.3390/jcm12165218 [doi] PST - epublish SO - J Clin Med. 2023 Aug 10;12(16):5218. doi: 10.3390/jcm12165218.