PMID- 37629773
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20230831
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 8
DP  - 2023 Aug 17
TI  - Clinical Research in Chronic Lymphocytic Leukemia in Pakistan; A Systematic 
      Review.
LID - 10.3390/medicina59081483 [doi]
LID - 1483
AB  - Background: Significant advances have been made in the treatment of chronic 
      lymphocytic leukemia (CLL) since the turn of the new millennium. However, most 
      clinical trials were done in developed countries where minority ethnicities were 
      underrepresented. Materials and Methods: To gauge the quality of research in CLL 
      being done in Pakistan, we conducted a comprehensive literature search using 
      PubMed, Clinicaltrials.gov, and Google Scholar on 14 January 2022 following the 
      Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 
      recommendations. Results: A total of 16 studies met the inclusion criteria. The 
      most common study design was cross-sectional. Eight studies evaluated the 
      clinicohematological profile of CLL patients and the effect of various cytogenic 
      abnormalities through fluorescence in situ hybridization (FISH) technique on 
      disease progression and prognosis. Five studies discussed the prevalence of 
      abnormalities such as autoimmune cytopenias and other serum chemistry 
      derangements. Only two studies evaluated treatment outcomes, among which one 
      study reported a 2-year overall survival of 65% among patients with 17p deletion. 
      None of the studies had patients on novel targeted agents. No pharmaceutical 
      sponsored or funded clinical trials were found. Conclusions: Our review suggests 
      that although small clinical studies continue to be performed across the country, 
      multiple financial and logistical barriers need to be addressed for larger, more 
      impactful clinical trials to be conducted that will help answer 
      demographic-specific questions and decrease reliance on foreign studies.
FAU - Ammad Ud Din, Mohammad
AU  - Ammad Ud Din M
AD  - Hematology/ Oncology, Moffitt Cancer Center, University of South Florida, 12902 
      USF Magnolia Drive, Tampa, FL 33612, USA.
AD  - Hematology/ Oncology, University of South Florida, Tampa, FL 33612, USA.
FAU - Shahzad, Moazzam
AU  - Shahzad M
AD  - Hematology/ Oncology, Moffitt Cancer Center, University of South Florida, 12902 
      USF Magnolia Drive, Tampa, FL 33612, USA.
AD  - Hematology/ Oncology, University of South Florida, Tampa, FL 33612, USA.
FAU - Ashraf, Aqsa
AU  - Ashraf A
AD  - Internal Medicine, Northwell Health Mather Hospital, Port Jefferson, New York, NY 
      11777, USA.
FAU - Liaqat, Hania
AU  - Liaqat H
AD  - Internal Medicine, Rochester General Hospital, Rochester, New York, NY 14621, 
      USA.
FAU - Jaan, Ali
AU  - Jaan A
AD  - Internal Medicine, Rochester General Hospital, Rochester, New York, NY 14621, 
      USA.
FAU - Anwer, Faiz
AU  - Anwer F
AD  - Hematology/ Oncology, Cleveland Clinic, Cleveland, OH 44195, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20230817
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Humans
MH  - Pakistan/epidemiology
MH  - Cross-Sectional Studies
MH  - In Situ Hybridization, Fluorescence
MH  - *Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology/genetics
MH  - Disease Progression
PMC - PMC10456454
OTO - NOTNLM
OT  - Pakistan
OT  - blood malignancies
OT  - chronic lymphocytic leukemia
OT  - malignant hematology
OT  - small cell leukemia
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/26 10:44
MHDA- 2023/08/28 06:41
PMCR- 2023/08/17
CRDT- 2023/08/26 01:21
PHST- 2023/07/15 00:00 [received]
PHST- 2023/08/12 00:00 [revised]
PHST- 2023/08/16 00:00 [accepted]
PHST- 2023/08/28 06:41 [medline]
PHST- 2023/08/26 10:44 [pubmed]
PHST- 2023/08/26 01:21 [entrez]
PHST- 2023/08/17 00:00 [pmc-release]
AID - medicina59081483 [pii]
AID - medicina-59-01483 [pii]
AID - 10.3390/medicina59081483 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 Aug 17;59(8):1483. doi: 10.3390/medicina59081483.