PMID- 37631375
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230829
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 15
IP  - 8
DP  - 2023 Aug 19
TI  - Constructing ROS-Responsive Supramolecular Gel with Innate Antibacterial 
      Properties.
LID - 10.3390/pharmaceutics15082161 [doi]
LID - 2161
AB  - Bacterial infections, especially antibiotic-resistant bacterial infections, pose 
      a significant threat to human health. Supramolecular gel with innate 
      antibacterial properties is an advanced material for the treatment of bacterial 
      infections, which have attracted great attention. Herein, a reactive oxygen 
      species (ROS)-responsive innate antibacterial supramolecular gel is developed by 
      a bottom-up approach based on phenylalanine and hydrazide with innate 
      antibacterial properties. The structure of gelators and intermediate products was 
      characterized by proton nuclear magnetic resonance ((1)H NMR) and a 
      high-resolution mass spectrum (HRMS). The results of (1)H NMR and the Fourier 
      transform infrared spectrum (FT-IR) experiment disclosed that hydrogen bonding 
      and the pi-pi stacking force are the important self-assembly driving forces of 
      gelators. The microstructure and mechanical properties of gel were studied by 
      Scanning electron microscope (SEM) and Rheometer, respectively. An in vitro 
      degradation experiment proved that the gelator has ROS-responsive degradation 
      properties. The in vitro drug release experiment further manifested that 
      antibiotic-loaded gel has ROS-responsive drug-release performances. An in vitro 
      cytotoxicity experiment showed that the supramolecular gel has good 
      biocompatibility and could promote cell proliferation. The in vitro antibacterial 
      experiment proved that the supramolecular gel has excellent inherent 
      antibacterial properties, and the antibacterial rate against Staphylococcus 
      aureus (S. aureus) and Escherichia coli (E. coli) was 98.6% and 99.1%, 
      respectively. The ROS-responsive supramolecular gel as a novel antibacterial 
      agent has great application prospects in treating antibiotic-resistant 
      bacterial-infected wounds and preventing the development of bacterial resistance.
FAU - Zheng, Fen
AU  - Zheng F
AD  - School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 
      315211, China.
FAU - Du, Wei
AU  - Du W
AD  - Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou 
      510515, China.
FAU - Yang, Minggang
AU  - Yang M
AD  - Research Center for Human Tissues and Organs Degeneration, Shenzhen Institute of 
      Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
FAU - Liu, Kaige
AU  - Liu K
AD  - School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 
      315211, China.
FAU - Zhang, Shanming
AU  - Zhang S
AD  - School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 
      315211, China.
FAU - Xu, Long
AU  - Xu L
AUID- ORCID: 0000-0002-0510-420X
AD  - School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 
      315211, China.
FAU - Wen, Yong
AU  - Wen Y
AD  - Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou 
      510515, China.
LA  - eng
GR  - 22105109/National Nature Science Foundation of China/
GR  - LQ21E030001/Natural Science Foundation of Zhejiang Province/
PT  - Journal Article
DEP - 20230819
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC10458117
OTO - NOTNLM
OT  - ROS-responsive
OT  - antibacterial gel
OT  - biocompatibility
OT  - low molecular weight gelator
OT  - supramolecular gel
COIS- The authors declare no conflict of interest.
EDAT- 2023/08/26 10:43
MHDA- 2023/08/26 10:44
PMCR- 2023/08/19
CRDT- 2023/08/26 01:30
PHST- 2023/07/19 00:00 [received]
PHST- 2023/08/15 00:00 [revised]
PHST- 2023/08/17 00:00 [accepted]
PHST- 2023/08/26 10:44 [medline]
PHST- 2023/08/26 10:43 [pubmed]
PHST- 2023/08/26 01:30 [entrez]
PHST- 2023/08/19 00:00 [pmc-release]
AID - pharmaceutics15082161 [pii]
AID - pharmaceutics-15-02161 [pii]
AID - 10.3390/pharmaceutics15082161 [doi]
PST - epublish
SO  - Pharmaceutics. 2023 Aug 19;15(8):2161. doi: 10.3390/pharmaceutics15082161.