PMID- 37633073
OWN - NLM
STAT- MEDLINE
DCOM- 20230905
LR  - 20230918
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 37
IP  - 9
DP  - 2023 Sep
TI  - Association between remnant cholesterol level and severity of chronic kidney 
      disease in patients with type 2 diabetes.
PG  - 108585
LID - S1056-8727(23)00183-6 [pii]
LID - 10.1016/j.jdiacomp.2023.108585 [doi]
AB  - BACKGROUND: Studies on whether remnant cholesterol (RC) affects the progression 
      of chronic kidney disease (CKD) remain insufficient. This study aimed to 
      determine whether RC level was associated with the severity of CKD in patients 
      with type 2 diabetes mellitus (T2DM). METHODS: In total, 3383 individuals 
      diagnosed with T2DM were enrolled in this cross-sectional study from China. The 
      severity of CKD was defined as no, moderate, severe, and very severe CKD based on 
      the urinary albumin-to-creatinine ratio and estimated glomerular filtration rate. 
      Because RC was non-normally distributed, it was log-transformed and categorized 
      into quantiles. Multivariate logistic regression and multivariate ordinal 
      logistic regression analysis were performed to investigate whether RC was 
      independently associated with CKD and its severity. RESULTS: The median RC level 
      was 25.9 mg/dL. The number of patients with no, moderate, severe, and very severe 
      CKD was 2587 (76.5 %), 520 (15.4 %), 189 (5.6 %), and 87 (2.5 %), respectively. 
      After adjusting for confounding factors, the prevalence of CKD increased 
      1.67-fold when the log-transformed RC level was elevated by one unit (OR [95 % 
      CI], 1.67 [1.43-1.95]). The likelihood of CKD severity increasing by one degree 
      was 1.76-fold for each one-unit increase in log-transformed RC level (OR [95 % 
      CI], 1.76 [1.52-2.05]). When RC was incorporated as a categorical variable, it 
      still correlated with CKD severity compared with quantile 1 (Q1) (Q2, 1.30 
      [1.01-1.68]; Q3, 1.60 [1.23-2.07]; Q4, 2.39 [1.86-3.09]). The association 
      remained regardless of whether the patient's traditional lipid profiles achieved 
      the target range. CONCLUSION: RC level was associated with CKD severity even when 
      traditional lipid profiles were within the target range in patients with T2DM.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Yuan, Yanping
AU  - Yuan Y
AD  - Department of Endocrinology, Peking University People's Hospital, Beijing 100044, 
      China.
FAU - Zhou, Xianghai
AU  - Zhou X
AD  - Department of Endocrinology, Peking University People's Hospital, Beijing 100044, 
      China. Electronic address: xianghai_zhou@bjmu.edu.cn.
FAU - Ji, Linong
AU  - Ji L
AD  - Department of Endocrinology, Peking University People's Hospital, Beijing 100044, 
      China. Electronic address: prof_jilinong@aliyun.com.
LA  - eng
PT  - Journal Article
DEP - 20230817
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Lipids)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Cross-Sectional Studies
MH  - China/epidemiology
MH  - *Renal Insufficiency, Chronic/complications/epidemiology
MH  - Lipids
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Lipid profile
OT  - Remnant cholesterol
OT  - Type 2 diabetes
COIS- Declaration of competing interest This study declares no conflict of interest.
EDAT- 2023/08/27 05:44
MHDA- 2023/09/05 06:42
CRDT- 2023/08/26 18:05
PHST- 2022/12/30 00:00 [received]
PHST- 2023/07/30 00:00 [revised]
PHST- 2023/08/08 00:00 [accepted]
PHST- 2023/09/05 06:42 [medline]
PHST- 2023/08/27 05:44 [pubmed]
PHST- 2023/08/26 18:05 [entrez]
AID - S1056-8727(23)00183-6 [pii]
AID - 10.1016/j.jdiacomp.2023.108585 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2023 Sep;37(9):108585. doi: 
      10.1016/j.jdiacomp.2023.108585. Epub 2023 Aug 17.