PMID- 37634256
OWN - NLM
STAT- MEDLINE
DCOM- 20230925
LR  - 20240210
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Print)
IS  - 1052-3057 (Linking)
VI  - 32
IP  - 10
DP  - 2023 Oct
TI  - Mediterranean-style diet and intracranial large artery stenosis in the Northern 
      Manhattan Study.
PG  - 107252
LID - S1052-3057(23)00275-6 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2023.107252 [doi]
AB  - OBJECTIVES: Given Mediterranean-style diet (MeDi) reduces risk of cardiovascular 
      events, we hypothesized MeDi may also be protective against intracranial large 
      artery stenosis (ICAS), a common cause of stroke worldwide. METHODS: This 
      cross-sectional study included stroke-free participants of the Northern Manhattan 
      Study, a diverse population-based study of stroke risk factors. We represented 
      MeDi continuously (range 0-8) based on enrollment food frequency questionnaires, 
      excluding alcohol consumption. We evaluated ICAS both dichotomously at clinically 
      relevant stenosis severities and continuously as a score (possible range 0-44), 
      summated from stenosis severity scores of major intracranial arteries from 
      time-of-flight magnetic resonance angiography. We used logistic or zero-inflated 
      Poisson regression, adjusting for key confounders. RESULTS: Among 912 included 
      participants (mean age 64+/-8 years, 59% female, 65% Hispanic, mean MeDi score 
      4+/-1.5), 5% and 8% of participants had >/=50% or >/=70% ICAS, respectively (score 
      median [interquartile range]: 0 [0-2]). Increased MeDi score was inversely 
      associated with ICAS, but did not reach statistical significance (>/=50% stenosis 
      odds ratio (OR) [95% confidence interval (CI)]: 0.89 [0.79-1.06]; >/=70% stenosis 
      OR [95% CI]: 0.91 [0.74-1.13]; stenosis score beta-estimate [95% CI]: -0.02 
      [-0.06-0.01]). CONCLUSION: In this stroke-free subsample, we did not find a 
      significant association between MeDi and ICAS. We may have been limited by 
      statistical power.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Yang, Dixon
AU  - Yang D
AD  - Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia 
      University, New York, NY, USA.
FAU - Gardener, Hannah
AU  - Gardener H
AD  - Department of Neurology, University of Miami Miller School of Medicine, Miami, 
      FL, USA.
FAU - Khasiyev, Farid
AU  - Khasiyev F
AD  - Department of Neurology, Saint Louis University, Saint Louis, MO, USA.
FAU - Rundek, Tatjana
AU  - Rundek T
AD  - Department of Neurology, Saint Louis University, Saint Louis, MO, USA; Evelyn 
      McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, 
      FL, USA.
FAU - Wright, Clinton B
AU  - Wright CB
AD  - National Institute of Neurologic Disorders and Stroke, Bethesda, MD, USA.
FAU - Elkind, Mitchell Sv
AU  - Elkind MS
AD  - Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia 
      University, New York, NY, USA; Department of Epidemiology, Mailman School of 
      Public Health, Columbia University, New York, NY, USA; American Heart 
      Association, USA.
FAU - Gutierrez, Jose
AU  - Gutierrez J
AD  - Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia 
      University, New York, NY, USA. Electronic address: jg3233@cumc.columbia.edu.
LA  - eng
GR  - R56 NS029993/NS/NINDS NIH HHS/United States
GR  - T32 NS007153/NS/NINDS NIH HHS/United States
GR  - R37 NS029993/NS/NINDS NIH HHS/United States
GR  - R01 AG057709/AG/NIA NIH HHS/United States
GR  - R01 AG066162/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20230825
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
SB  - IM
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Aged
MH  - Male
MH  - Cross-Sectional Studies
MH  - Constriction, Pathologic/complications
MH  - *Stroke/etiology
MH  - Risk Factors
MH  - *Diet, Mediterranean
MH  - Arteries
MH  - *Intracranial Arteriosclerosis/diagnostic imaging/epidemiology/complications
PMC - PMC10528497
MID - NIHMS1929407
OTO - NOTNLM
OT  - Intracranial large artery stenosis
OT  - Mediterranean-style diet
OT  - Northern Manhattan study
OT  - Stroke
COIS- Declaration of Competing Interest Ms. Ref. No.: JSCVD-D-23-00359 Title: 
      Mediterranean-style diet and intracranial large artery stenosis in the Northern 
      Manhattan Study Journal of Stroke and Cerebrovascular Diseases The following 
      authors declare interests outside of the submitted work: Dr. Tatjana Rundek 
      reported grant funding from National Institute of Health/National Institute of 
      Neurological Diseases and Stroke (NIH/NINDS) outside of the submitted work. Dr. 
      Mitchell Elkind reported receipt of royalties for chapters on stroke published in 
      UpToDate and is an employee of the American Heart Association, outside of the 
      present work. Dr. Jose Gutierrez reported receiving grant funding from the 
      NIH/National Institute of Aging (NIA) and receipt of royalties for chapters on 
      intracranial atherosclerosis published in UpToDate and on lacunar strokes 
      published in Medlink, outside of the submitted work. All other authors declare no 
      potential conflicts of interest.
EDAT- 2023/08/27 18:41
MHDA- 2023/09/25 06:42
PMCR- 2024/10/01
CRDT- 2023/08/27 17:59
PHST- 2023/02/27 00:00 [received]
PHST- 2023/07/07 00:00 [revised]
PHST- 2023/07/11 00:00 [accepted]
PHST- 2024/10/01 00:00 [pmc-release]
PHST- 2023/09/25 06:42 [medline]
PHST- 2023/08/27 18:41 [pubmed]
PHST- 2023/08/27 17:59 [entrez]
AID - S1052-3057(23)00275-6 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2023.107252 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2023 Oct;32(10):107252. doi: 
      10.1016/j.jstrokecerebrovasdis.2023.107252. Epub 2023 Aug 25.