PMID- 37634502
OWN - NLM
STAT- MEDLINE
DCOM- 20231207
LR  - 20231207
IS  - 1421-9832 (Electronic)
IS  - 1018-8665 (Linking)
VI  - 239
IP  - 6
DP  - 2023
TI  - Chronic Spontaneous Urticaria in Belgium: Deciphering the Clinical Profile and 
      Treatment of Patients Visiting an Urban City Immunology Department.
PG  - 926-936
LID - 10.1159/000533394 [doi]
AB  - BACKGROUND: Chronic urticaria (CSU) is a chronic inflammatory mast cell-driven 
      disorder of which reliable clinical data in Belgium are lacking. This study 
      focusses on clinical characteristics of CSU patients presenting at an urban 
      Immunology-Allergology department. METHODS: Outpatients with CSU were included 
      from 2018 to 2021. Clinical characteristics, Dermatology Life Quality Index 
      (DLQI) and Urticaria activity score (UAS7) were collected by thorough anamnesis 
      and questionnaires. Furthermore, patients underwent provocational testing, an 
      autologous serum skin test (ASST) and a blood analysis. RESULTS: The study 
      included 49 CSU patients and 20 non-CSU subjects. CSU was distributed differently 
      with age and sex, showing higher numbers in female patients below the age of 46 
      years. 67% of CSU patients had accompanying angioedema of which 9% were reported 
      genital. CSU patients scored a mean 8/30 on their DLQI questionnaire. There was 
      no significant difference in immunoglobulin E (IgE), C-reactive protein, and 
      tryptase levels between CSU patients and controls. Oral glucocorticosteroids were 
      prescribed in 23% of CSU patients during their disease course though only half of 
      these patients had a severity grade 4 CSU. In 82% of the included CSU patients, 
      Urticaria Control Test (UCT) scores were below 12. When we hypothetically 
      considered low IgE levels and high IgG anti-thyroid peroxidase levels as 
      differentiation marker for autoimmune (ai)CSU and non-aiCSU, we found that 4% of 
      all included CSU patients could be considered aiCSU. CONCLUSION: Generally, the 
      inner-city population displayed the same clinical characteristics, as previous 
      cohorts from Northern Europe. The relatively high rate of CSU patients receiving 
      oral glucocorticosteroid treatment for their disease though not always classified 
      as severe, underlines the need to train doctors of various specialties in the 
      treatment algorithms of CSU. Furthermore, by looking at potential autoimmune 
      characteristics, our findings open perspectives on the identification of new 
      routinely used clinical parameters for the detection of aiCSU, a relatively small 
      immunological subtype of CSU.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Mostmans, Yora
AU  - Mostmans Y
AD  - Department of Immunology-Allergology, CHU Brugmann, Universite Libre de 
      Bruxelles, Laken, Belgium.
AD  - Department of Dermatology, CHU Brugmann, Universite Libre de Bruxelles, Laken, 
      Belgium.
FAU - Richert, Bertrand
AU  - Richert B
AD  - Department of Dermatology, CHU Brugmann, Universite Libre de Bruxelles, Laken, 
      Belgium.
FAU - De Maertelaer, Viviane
AU  - De Maertelaer V
AD  - IRIBHM, Statistical Unit, Fac. Medicine, Universite Libre de Bruxelles, 
      Anderlecht, Belgium.
FAU - Saidi, Ines
AU  - Saidi I
AD  - Department of Dermatology, CHU Brugmann, Universite Libre de Bruxelles, Laken, 
      Belgium.
FAU - Benslimane, Asma
AU  - Benslimane A
AD  - Department of Immunology, Laboratoire Hospitalier Universitaire de 
      Bruxelles/Universitair Laboratorium Brussels (LHUB-ULB), Brussels, Belgium.
FAU - Thi Thanh, Thao Tran
AU  - Thi Thanh TT
AD  - Department of Immunology, Laboratoire Hospitalier Universitaire de 
      Bruxelles/Universitair Laboratorium Brussels (LHUB-ULB), Brussels, Belgium.
FAU - Corazza, Francis
AU  - Corazza F
AD  - Department of Immunology, Laboratoire Hospitalier Universitaire de 
      Bruxelles/Universitair Laboratorium Brussels (LHUB-ULB), Brussels, Belgium.
FAU - Michel, Olivier
AU  - Michel O
AD  - Department of Immunology-Allergology, CHU Brugmann, Universite Libre de 
      Bruxelles, Laken, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20230825
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Belgium
MH  - *Chronic Urticaria/drug therapy
MH  - *Urticaria/drug therapy
MH  - Disease Progression
MH  - Immunoglobulin E
MH  - Chronic Disease
OTO - NOTNLM
OT  - Belgium
OT  - Chronic spontaneous urticaria
OT  - Clinical profile
OT  - Descriptive analysis
OT  - Treatment
EDAT- 2023/08/28 00:41
MHDA- 2023/12/07 12:42
CRDT- 2023/08/27 18:23
PHST- 2023/01/17 00:00 [received]
PHST- 2023/07/31 00:00 [accepted]
PHST- 2023/12/07 12:42 [medline]
PHST- 2023/08/28 00:41 [pubmed]
PHST- 2023/08/27 18:23 [entrez]
AID - 000533394 [pii]
AID - 10.1159/000533394 [doi]
PST - ppublish
SO  - Dermatology. 2023;239(6):926-936. doi: 10.1159/000533394. Epub 2023 Aug 25.