PMID- 37635870
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230829
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 11
DP  - 2023
TI  - Therapeutic effects of different intervention forms of human umbilical cord 
      mesenchymal stem cells in the treatment of osteoarthritis.
PG  - 1246504
LID - 10.3389/fcell.2023.1246504 [doi]
LID - 1246504
AB  - Osteoarthritis (OA) is a common and disabling disease. For advanced OA, surgical 
      treatment is still the main treatment. Human umbilical cord mesenchymal stem 
      cells (hUC-MSCs) are self-regenerative pluripotent cells, that coordinate 
      cartilage regeneration by secreting various trophic factors, which adjust the 
      injured tissue environment. hUC-MSCs secret extracellular vesicles and 
      participates in OA treatment by transmitting bioactive molecules related to 
      migration, proliferation, apoptosis, inflammatory reaction, extracellular matrix 
      synthesis and cartilage repair. In addition, the combination of multiple 
      substances represented by cartilage matrix and hUC-MSCs also have a significant 
      synergistic effect on OA treatment. Because hUC-MSCs have shown considerable 
      promise in cartilage repair, some scholars have proposed transplanting 
      mesenchymal stem cells into damaged cartilage to delay OA progression. This 
      article reviews the application of hUC-MSCs as a treatment for OA. With the 
      continuous development of routine clinical applications, more reliable 
      intervention modalities for hUC-MSCs in OA treatment will be discovered for the 
      time to come.
CI  - Copyright (c) 2023 Zhang, Zhuang, Ren, Jiang and Zhou.
FAU - Zhang, Yuelong
AU  - Zhang Y
AD  - Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Zhuang, Huangming
AU  - Zhuang H
AD  - Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Ren, Xunshan
AU  - Ren X
AD  - Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Jiang, Fuze
AU  - Jiang F
AD  - Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Zhou, Panghu
AU  - Zhou P
AD  - Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230810
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC10448389
OTO - NOTNLM
OT  - cell therapy
OT  - extracellular vesicles
OT  - human umbilical cord mesenchymal stem cells
OT  - mesenchymal stem cells
OT  - osteoarthritis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/28 06:42
MHDA- 2023/08/28 06:43
PMCR- 2023/01/01
CRDT- 2023/08/28 04:27
PHST- 2023/06/24 00:00 [received]
PHST- 2023/08/02 00:00 [accepted]
PHST- 2023/08/28 06:43 [medline]
PHST- 2023/08/28 06:42 [pubmed]
PHST- 2023/08/28 04:27 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 1246504 [pii]
AID - 10.3389/fcell.2023.1246504 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2023 Aug 10;11:1246504. doi: 10.3389/fcell.2023.1246504. 
      eCollection 2023.