PMID- 37636520
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230919
IS  - 2328-8957 (Print)
IS  - 2328-8957 (Electronic)
IS  - 2328-8957 (Linking)
VI  - 10
IP  - 8
DP  - 2023 Aug
TI  - Role of the Killer Immunoglobulin-like Receptor and Human Leukocyte Antigen I 
      Complex Polymorphisms in Kaposi Sarcoma-Associated Herpesvirus Infection.
PG  - ofad435
LID - 10.1093/ofid/ofad435 [doi]
LID - ofad435
AB  - BACKGROUND: Kaposi sarcoma, caused by the pathogen Kaposi sarcoma-associated 
      herpesvirus (KSHV), is the most common neoplasm for patients with AIDS. 
      Susceptibility to KSHV has been associated with several different genetic risk 
      variants. The purpose of this study was to test whether variants of killer cell 
      immunoglobulin-like receptors (KIRs) and their human leukocyte antigen (HLA-I) 
      ligands influence the risk of KSHV infection. METHODS: A case-control study was 
      performed in Xinjiang, a KSHV-endemic region of China. We recruited 299 
      individuals with HIV, including 123 KSHV-seropositive persons and 176 
      KSHV-seronegative controls. We used logistic regression and the MiDAS package to 
      evaluate the association between KIR/HLA-I polymorphisms and KSHV infection. 
      RESULTS: HLA-A*31:01, HLA-C*03:04, and HLA-C*12:03 were found to be associated 
      with KSHV infection, with A*31:01 showing a protective effect under 3 different 
      models (dominant: 0.30 [95% confidence interval CI, .08-.82], P = .031; 
      additive: 0.30 [95% CI, .09-.80], P = .030; overdominant: 0.31 [95% CI, .09-.88], 
      P = .042). The effect of A*31:01 might cause the variants of amino acid at HLA-A 
      position 56, with individuals carrying an arginine having a lower KSHV infection 
      risk. The increased homozygous KIR2DL3 was associated with a relatively high KSHV 
      viral load (16.30% vs 41.94%, P = .010). CONCLUSIONS: This study provides further 
      insight into the link between HLA-I alleles and KIR genes and KSHV infection, 
      highlighting KSHV-susceptible variants of HLA-I and KSHV replication caused by 
      specific KIR genotype, and revealing a potential role of KIR-mediated natural 
      killer cell activation in anti-KSHV infection.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of 
      Infectious Diseases Society of America.
FAU - Zhang, Xin
AU  - Zhang X
AUID- ORCID: 0000-0002-4814-6207
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, 
      Shanghai, China.
FAU - Li, Yi
AU  - Li Y
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, 
      Shanghai, China.
FAU - Han, Xinyu
AU  - Han X
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, 
      Shanghai, China.
FAU - Xu, Yiyun
AU  - Xu Y
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, 
      Shanghai, China.
FAU - Wang, Haili
AU  - Wang H
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, 
      Shanghai, China.
FAU - Wang, Tianye
AU  - Wang T
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, 
      Shanghai, China.
FAU - Zhang, Tiejun
AU  - Zhang T
AUID- ORCID: 0000-0002-5187-7393
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, 
      Shanghai, China.
AD  - Shanghai Institute of Infectious Disease and Biosecurity, School of Public 
      Health, Fudan University, Shanghai, China.
AD  - Yiwu Research Institute, Fudan University, Yiwu, China.
LA  - eng
PT  - Journal Article
DEP - 20230818
PL  - United States
TA  - Open Forum Infect Dis
JT  - Open forum infectious diseases
JID - 101637045
PMC - PMC10456215
OTO - NOTNLM
OT  - Kaposi sarcoma-associated herpesvirus
OT  - human leukocyte antigen
OT  - infection
OT  - killer cell immunoglobulin-like receptor
OT  - polymorphism
COIS- Potential conflicts of interest. All authors report no potential conflicts.
EDAT- 2023/08/28 06:42
MHDA- 2023/08/28 06:43
PMCR- 2023/08/18
CRDT- 2023/08/28 04:37
PHST- 2023/06/09 00:00 [received]
PHST- 2023/08/15 00:00 [accepted]
PHST- 2023/08/28 06:43 [medline]
PHST- 2023/08/28 06:42 [pubmed]
PHST- 2023/08/28 04:37 [entrez]
PHST- 2023/08/18 00:00 [pmc-release]
AID - ofad435 [pii]
AID - 10.1093/ofid/ofad435 [doi]
PST - epublish
SO  - Open Forum Infect Dis. 2023 Aug 18;10(8):ofad435. doi: 10.1093/ofid/ofad435. 
      eCollection 2023 Aug.