PMID- 37636563
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231103
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 10
DP  - 2023
TI  - Immune reconstitution inflammatory syndrome, a controversial burden in the East 
      African context: a systematic review and meta-analysis.
PG  - 1192086
LID - 10.3389/fmed.2023.1192086 [doi]
LID - 1192086
AB  - INTRODUCTION: It is well established that starting antiretroviral therapy (ART) 
      increases a patient's life expectancy among HIV-positive individuals. Considering 
      the HIV pandemic, the major concern is initiation of ARTs to the large segment of 
      HIV infected population, not adverse events from immune restoration. The 
      prevalence of HIV-associated immune reconstitution inflammatory syndrome (IRIS) 
      is poorly estimated due to Africa's underdeveloped infrastructure, particularly 
      in Eastern Africa. Therefore, this study compiled data regarding the magnitude 
      and associated factors of IRIS in the context of Eastern Africa. METHODS: The 
      electronic databases such as Google Scholar, PubMed, Web of Science, and free 
      Google access were searched till 5 June 2021, and the search was lastly updated 
      on 30 June 2022 for studies of interest. The pooled prevalence, and associated 
      factors with a 95% confidence interval were estimated using the random effects 
      model. The I(2) and Egger's tests were used for heterogeneity and publication 
      bias assessment, respectively. RESULTS: The development of HIV-associated IRIS in 
      Eastern Africa was estimated to be 18.18% (95% CI 13.30-23.06) in the current 
      review. The two most common predictors of IRIS associated with Eastern Africa 
      were the lower pre-ART CD4 T-cell count of 50 cells/mul and the low baseline body 
      mass index level. Therefore, attention should be focused on the early detection 
      and care of HIV-associated IRIS to reduce the morbidity and death caused by IRIS.
CI  - Copyright (c) 2023 Geteneh, Andualem, Belay, Kiros and Biset.
FAU - Geteneh, Alene
AU  - Geteneh A
AD  - Department of Medical Laboratory Science, College of Health Sciences, Woldia 
      University, Woldia, Ethiopia.
FAU - Andualem, Henok
AU  - Andualem H
AD  - Department of Medical Laboratory Science, College of Medicine and Health 
      Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
FAU - Belay, Demeke Mesfin
AU  - Belay DM
AD  - Department of Pediatrics and Child Health Nursing, College of Health Sciences, 
      Debre Tabor University, Debre Tabor, Ethiopia.
FAU - Kiros, Mulugeta
AU  - Kiros M
AD  - Department of Medical Laboratory Science, College of Medicine and Health 
      Sciences, Aksum University, Aksum, Ethiopia.
FAU - Biset, Sirak
AU  - Biset S
AD  - Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, 
      College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
LA  - eng
PT  - Systematic Review
DEP - 20230810
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC10450628
OTO - NOTNLM
OT  - ART
OT  - East Africa
OT  - HIV
OT  - HIV-associated IRIS
OT  - IRIS
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/28 06:42
MHDA- 2023/08/28 06:43
PMCR- 2023/08/10
CRDT- 2023/08/28 04:38
PHST- 2023/03/23 00:00 [received]
PHST- 2023/07/18 00:00 [accepted]
PHST- 2023/08/28 06:43 [medline]
PHST- 2023/08/28 06:42 [pubmed]
PHST- 2023/08/28 04:38 [entrez]
PHST- 2023/08/10 00:00 [pmc-release]
AID - 10.3389/fmed.2023.1192086 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2023 Aug 10;10:1192086. doi: 10.3389/fmed.2023.1192086. 
      eCollection 2023.