PMID- 37636709 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230928 IS - 2231-3796 (Print) IS - 0973-7707 (Electronic) IS - 2231-3796 (Linking) VI - 75 IP - 3 DP - 2023 Sep TI - Tumor Volume Staging Provides a Comparable Stratifying for Laryngeal Squamous Cell Cancer According to T Stages. PG - 1344-1351 LID - 10.1007/s12070-023-03522-w [doi] AB - The prognostic significance of tumor volume (TV) in laryngeal squamous cell cancer (LSCC) has been demonstrated previously. Still, its clinical use is uncertain, and a method for accurate staging for TV is lacking. This study aimed to develop an objective staging and determine the effect of tumor volume on disease outcome after surgical treatment for LSCC. This study was designed retrospectively. Patients with LSCC who underwent laryngectomy were identified. Discretization for optimal scaling level of Tumor Volume (TV) was performed by Catreg Version 3.0. The rate of cancer recurrence, disease-free survival (DFS), and overall survival (OS) rate were calculated and compared between T stage and TV staging. Kaplan-Meier survival analysis was performed for comparison. 206 LSCC patients enrolled in the study. TV was found significantly higher in patients with cartilage invasion, contralateral nodal metastasis, and extranodal extension (p = 0.004, 0.010, and 0.021, respectively). TV and lymph node density LND showed a low significant positive correlation (p = 0.015, r = 0.169). TV was 7.25 + 7.53 ml on average, and TV above the mean value was found to be an independent risk factor for OS and DFS (p = 0.043, HR = 1.8; CI95% for HR: 1.02-3.44 and p < 0.001, HR = 3.7; CI95% for HR: 1.8-7.3, respectively). The optimal scaling level of TV was found in three-level; group 1: TV /= 14.10. This categorization of TV has obtained significant discretization between patients for DFS and OS (Long-Rank = 0.038 and < 0.001). This classification may provide better performance in addition to helping the T stage in determining prognosis, especially in patients with advanced laryngeal SCC. CI - (c) Association of Otolaryngologists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Ozkul, Yilmaz AU - Ozkul Y AUID- ORCID: 0000-0001-6603-3903 AD - Department of Otorhinolaryngology, Izmir Katip Celebi University Medical Faculty, Izmir, Turkey. GRID: grid.411795.f. ISNI: 0000 0004 0454 9420 FAU - Islek, Akif AU - Islek A AUID- ORCID: 0000-0001-7058-3457 AD - Otolaryngology-Head & Neck Surgery Clinic, Acibadem Eskisehir Hospital, Hosnudiye Mah, Acibadem Sk. No: 19, Tepebasi, Eskisehir, Turkey. FAU - Bayrak, Asuman Feda AU - Bayrak AF AUID- ORCID: 0000-0001-8403-3018 AD - Department of Otorhinolaryngology, Izmir Katip Celebi University Medical Faculty, Izmir, Turkey. GRID: grid.411795.f. ISNI: 0000 0004 0454 9420 FAU - Akdag, Ecem AU - Akdag E AUID- ORCID: 0000-0002-2646-0908 AD - Department of Otorhinolaryngology, Izmir Katip Celebi University Medical Faculty, Izmir, Turkey. GRID: grid.411795.f. ISNI: 0000 0004 0454 9420 FAU - Etit, Demet AU - Etit D AUID- ORCID: 0000-0002-6282-0173 AD - Department of Otorhinolaryngology, Izmir Katip Celebi University Medical Faculty, Izmir, Turkey. GRID: grid.411795.f. ISNI: 0000 0004 0454 9420 LA - eng PT - Journal Article DEP - 20230213 PL - India TA - Indian J Otolaryngol Head Neck Surg JT - Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India JID - 9422551 PMC - PMC10447356 OTO - NOTNLM OT - Laryngeal squamous cell cancer OT - Prognosis OT - TNM OT - Tumor volume COIS- Conflict of interestThe authors declare none. EDAT- 2023/08/28 06:42 MHDA- 2023/08/28 06:43 PMCR- 2024/09/01 CRDT- 2023/08/28 04:39 PHST- 2022/06/06 00:00 [received] PHST- 2023/01/22 00:00 [accepted] PHST- 2024/09/01 00:00 [pmc-release] PHST- 2023/08/28 06:43 [medline] PHST- 2023/08/28 06:42 [pubmed] PHST- 2023/08/28 04:39 [entrez] AID - 3522 [pii] AID - 10.1007/s12070-023-03522-w [doi] PST - ppublish SO - Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):1344-1351. doi: 10.1007/s12070-023-03522-w. Epub 2023 Feb 13.