PMID- 37637052 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230829 IS - 2234-943X (Print) IS - 2234-943X (Electronic) IS - 2234-943X (Linking) VI - 13 DP - 2023 TI - A scientometric analysis of research trends on targeting mTOR in breast cancer from 2012 to 2022. PG - 1167154 LID - 10.3389/fonc.2023.1167154 [doi] LID - 1167154 AB - Over the past decade, thousands of articles have been published on the mechanistic target of rapamycin (mTOR) and its role in breast cancer. However, the variability and heterogeneity of academic data may impact the acquisition of published research information. Due to the large number, heterogeneity, and varying quality of publications related to mTOR and breast cancer, sorting out the present state of the research in this area is critical for both researchers and clinicians. Therefore, scientometric techniques and visualization tools were employed to analyze the large number of bibliographic metadata related to the research area of mTOR and breast cancer. The features of relevant publications were searched from 2012 to 2022 to evaluate the present status of research and the evolution of research hotspots in this particular field. Web of Science was utilized to extract all relevant publications from 2012 to 2022. Subsequently, Biblioshiny and VOSviewer were utilized to obtain data on the most productive countries, authors, and institutions, annual publications and citations, the most influential journals and articles, and the most frequently occurring keywords. In total, 1,471 publications were retrieved, comprising 1,167 original articles and 304 reviews. There was a significant rise in publications between 2015 and 2018, followed by a sharp decline in 2019 and a rebound since then. The publication with the highest number of citations was a 2012 review authored by Baselga et al. The United States had the highest number of publications, citations and connections among all countries. Oncotarget had the highest number of published articles among all the journals, and Jose Baselga had the strongest links with other authors. Excluding the search topics, the most frequently used words were "expression" (n = 297), "growth" (n = 228), "activation" (n = 223), "pathway" (n = 205), and "apoptosis" (n = 195). mTOR is crucially involved in breast cancer pathogenesis, but its exact mechanism of action remains controversial and warrants further investigation. The scientometric analysis provides a distinct overview of the existing state of research and highlights the topical issues that deserve further exploration. CI - Copyright (c) 2023 Zhang, Wu, Yang, Tian, Chen, Zheng, Ji, Cai, Chen and Li. FAU - Zhang, Xizhou AU - Zhang X AD - Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. FAU - Wu, Jinyao AU - Wu J AD - Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. FAU - Yang, Qiuping AU - Yang Q AD - Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. FAU - Tian, Huiting AU - Tian H AD - Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. FAU - Chen, Lingzhi AU - Chen L AD - Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. FAU - Zheng, Daitian AU - Zheng D AD - Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. FAU - Ji, Zeqi AU - Ji Z AD - Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. FAU - Cai, Jiehui AU - Cai J AD - Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. FAU - Chen, Yexi AU - Chen Y AD - Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. FAU - Li, Zhiyang AU - Li Z AD - Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. LA - eng PT - Journal Article DEP - 20230810 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC10448818 OTO - NOTNLM OT - VOSviewer OT - WoS OT - bibliometrix OT - breast cancer OT - mTOR OT - scientometrics COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/08/28 06:42 MHDA- 2023/08/28 06:43 PMCR- 2023/01/01 CRDT- 2023/08/28 04:43 PHST- 2023/04/20 00:00 [received] PHST- 2023/07/25 00:00 [accepted] PHST- 2023/08/28 06:43 [medline] PHST- 2023/08/28 06:42 [pubmed] PHST- 2023/08/28 04:43 [entrez] PHST- 2023/01/01 00:00 [pmc-release] AID - 10.3389/fonc.2023.1167154 [doi] PST - epublish SO - Front Oncol. 2023 Aug 10;13:1167154. doi: 10.3389/fonc.2023.1167154. eCollection 2023.