PMID- 37637187
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230829
IS  - 2213-4220 (Print)
IS  - 2213-4239 (Electronic)
IS  - 2213-4220 (Linking)
VI  - 12
IP  - 3
DP  - 2023 Sep
TI  - Thread-embedding acupuncture may improve symptom resolution in patients with 
      gastroesophageal reflux disease: A randomized controlled trial.
PG  - 100971
LID - 10.1016/j.imr.2023.100971 [doi]
LID - 100971
AB  - BACKGROUND: Various traditional medicine treatments have been investigated to 
      treat GERD. Among those, thread-embedding acupuncture (TEA) has the advantage 
      that patients need to undergo the procedure infrequently; however, its efficacy 
      is unclear. This study evaluated the efficacy of TEA in treating GERD. METHODS: A 
      randomized controlled trial was conducted with 66 participants with GERD: 33 
      received two sessions of TEA + standard therapy (proton-pump inhibitor [PPI]) 
      (TEA+PPI group) and 33 received PPI alone (PPI group). Primary outcomes included 
      GerdQ score and heartburn and regurgitation resolution. Secondary outcomes were 
      antacids requirement, the Frequency Scale for Symptoms of GERD (FSSG) score, and 
      Gastroesophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL) score. 
      The safety outcome was adverse events (AEs). RESULTS: After four weeks of 
      treatment, the TEA+PPI group significantly reduced the GerdQ score (mean 
      difference [MD] and 95% confidence interval [CI]: -1.8 [-2.4, -1.1]) and 
      increased the rate of heartburn and regurgitation resolution compared to PPI 
      (54.5% versus 9.1%, respectively) compared to PPI. The TEA+PPI group also 
      significantly reduced the number of antacid packs used (MD [95%-CI]: -9.4 [-12.1, 
      -6.7]), FSSG score (MD [95%-CI]: -9.4 [-11.0, -7.8]), and GERD-HRQL score (MD 
      [95%-CI]: -5.6 [-7.7, -3.5]) compared to PPI. Five patients experienced AEs, 
      which were mild local complications at the acupoints. CONCLUSION: TEA combined 
      with PPI is more effective than PPI alone in treating GERD. Further studies with 
      longer follow-ups are required to confirm these findings. CLINICAL TRIALS 
      REGISTRATION INFORMATION: ClinicalTrials.gov, NCT05353933.
CI  - (c) 2023 Korea Institute of Oriental Medicine. Published by Elsevier B.V.
FAU - Trinh, Dieu-Thuong Thi
AU  - Trinh DT
AD  - Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Ho Chi Minh City, Vietnam.
AD  - University Medical Center Ho Chi Minh City, University of Medicine and Pharmacy 
      at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
FAU - Tran, An Hoa
AU  - Tran AH
AD  - Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Ho Chi Minh City, Vietnam.
AD  - University Medical Center Ho Chi Minh City, University of Medicine and Pharmacy 
      at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
FAU - Bui, Minh-Man Pham
AU  - Bui MP
AD  - Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi 
      Minh City, Ho Chi Minh City, Vietnam.
AD  - University Medical Center Ho Chi Minh City, University of Medicine and Pharmacy 
      at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
FAU - Vuong, Nguyen Lam
AU  - Vuong NL
AD  - Department of Medical Statistics and Informatics, Faculty of Public Health, 
      University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, 
      Vietnam.
LA  - eng
SI  - ClinicalTrials.gov/NCT05353933
PT  - Journal Article
DEP - 20230707
PL  - Netherlands
TA  - Integr Med Res
JT  - Integrative medicine research
JID - 101612707
PMC - PMC10448015
OTO - NOTNLM
OT  - Acupuncture
OT  - GERD
OT  - Thread embedding acupuncture
OT  - Traditional medicine
EDAT- 2023/08/28 06:42
MHDA- 2023/08/28 06:43
PMCR- 2023/07/07
CRDT- 2023/08/28 04:45
PHST- 2023/03/28 00:00 [received]
PHST- 2023/06/20 00:00 [revised]
PHST- 2023/06/27 00:00 [accepted]
PHST- 2023/08/28 06:43 [medline]
PHST- 2023/08/28 06:42 [pubmed]
PHST- 2023/08/28 04:45 [entrez]
PHST- 2023/07/07 00:00 [pmc-release]
AID - S2213-4220(23)00050-1 [pii]
AID - 100971 [pii]
AID - 10.1016/j.imr.2023.100971 [doi]
PST - ppublish
SO  - Integr Med Res. 2023 Sep;12(3):100971. doi: 10.1016/j.imr.2023.100971. Epub 2023 
      Jul 7.