PMID- 37637574
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230829
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 7
DP  - 2023 Jul
TI  - Traditional Vietnamese Medicine Containing Garlic Extract for Patients With 
      Non-severe COVID-19: A Phase-II, Double-Blind, Randomized Controlled Trial.
PG  - e42484
LID - 10.7759/cureus.42484 [doi]
LID - e42484
AB  - Background Coronavirus disease 2019 (COVID-19) is still ongoing with the omicron 
      variant. Low-cost, effective treatments are still needed, particularly in 
      low-to-middle-income countries. This study assessed the safety and efficacy of 
      TD0068, an herbal medicine developed from mainly garlic, for patients with 
      non-severe COVID-19. Methods This is a phase-II, double-blind, randomized 
      controlled trial to compare oral capsule TD0068 and placebo in adults aged 18-65 
      years with non-severe COVID-19 between September and October 2021. The efficacy 
      outcomes measured included daily cycle threshold (Ct) value from the time of the 
      initial reverse transcription-polymerase chain reaction (RT-PCR) test, time to 
      viral clearance, daily symptom severity score from 15 symptoms of interest, time 
      to symptom resolution, and progression to severe/critical COVID-19. Safety 
      outcomes included adverse events (AEs) and serious adverse events (SAEs). Results 
      Sixty patients were randomized (31 received TD0068, and 29 received a placebo). 
      The two groups were balanced in baseline characteristics: mean age was 39 years, 
      and female was predominant (66%). Daily Ct value (median on days 3, 5, 7, and 9 
      was 25.7, 30.8, 35.4, and 37.6 in the TD0068 group, and 26.4, 31.2, 36.0, and 
      37.4 in the placebo group, respectively) and time to viral clearance (median: 10 
      vs. 11 days in TD0068 and placebo groups) were similar between groups. Daily 
      symptom severity score (median on days 3, 5, 7, and 9 was 2, 2, 1, and 0 in the 
      TD0068 group, and 3, 2, 1, and 1 in the placebo group), and time to symptom 
      resolution (median: seven vs. nine days, respectively) were also comparable 
      between groups. No SAE occurred in the study. Conclusions TD0068 is safe but does 
      not show an effect for non-severe COVID-19 patients. Further research is needed 
      to explore the potential benefits of garlic in other forms or dosages for the 
      treatment of COVID-19.
CI  - Copyright (c) 2023, Giang et al.
FAU - Giang, Tran Van
AU  - Giang TV
AD  - Department of Viral and Parasitic Diseases, National Hospital for Tropical 
      Diseases, Hanoi, VNM.
AD  - Department of Infectious Diseases, Hanoi Medical University, Hanoi, VNM.
FAU - Hoa, Le Nguyen Minh
AU  - Hoa LNM
AD  - Department of Microbiology and Molecular Biology, National Hospital for Tropical 
      Diseases, Hanoi, VNM.
FAU - Hien, Tran Thi
AU  - Hien TT
AD  - Department of Viral and Parasitic Diseases, National Hospital for Tropical 
      Diseases, Hanoi, VNM.
FAU - Cuong, Quach Duy
AU  - Cuong QD
AD  - Department of Viral and Parasitic Diseases, National Hospital for Tropical 
      Diseases, Hanoi, VNM.
FAU - Cap, Nguyen Trung
AU  - Cap NT
AD  - Emergency Department, National Hospital for Tropical Diseases, Hanoi, VNM.
FAU - Lam Vuong, Nguyen
AU  - Lam Vuong N
AD  - Department of Medical Statistics and Informatics, Faculty of Public Health, 
      University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VNM.
FAU - Thach, Pham Ngoc
AU  - Thach PN
AD  - Emergency Department, National Hospital for Tropical Diseases, Hanoi, VNM.
LA  - eng
PT  - Journal Article
DEP - 20230726
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10452047
OTO - NOTNLM
OT  - allium sativum
OT  - covid-19
OT  - garlic
OT  - herbal
OT  - sars-cov-2
OT  - traditional medicine
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/08/28 06:42
MHDA- 2023/08/28 06:43
PMCR- 2023/07/26
CRDT- 2023/08/28 04:51
PHST- 2023/07/25 00:00 [accepted]
PHST- 2023/08/28 06:43 [medline]
PHST- 2023/08/28 06:42 [pubmed]
PHST- 2023/08/28 04:51 [entrez]
PHST- 2023/07/26 00:00 [pmc-release]
AID - 10.7759/cureus.42484 [doi]
PST - epublish
SO  - Cureus. 2023 Jul 26;15(7):e42484. doi: 10.7759/cureus.42484. eCollection 2023 
      Jul.