PMID- 37637710
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230829
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 16
DP  - 2023
TI  - Retinal Vessel Density and Retinal Nerve Fiber Layer Thickness: A Prospective 
      Study of One-Year Follow-Up of Patients with Parkinson's Disease.
PG  - 3701-3712
LID - 10.2147/IJGM.S426501 [doi]
AB  - OBJECTIVE: This study aims to compare the superficial vascular density from the 
      macular region and the retinal nerve fiber layer (RNFL) thickness from the optic 
      disc region between Parkinson's disease (PD) patients and controls. METHODS: We 
      enrolled 56 idiopathic PD patients, totaling 86 eyes (PD group), and 45 sex- and 
      age-matched healthy individuals, amounting to 90 eyes (control group). All 
      subjects underwent examination using Zeiss wide-field vascular optical coherence 
      tomography (OCT) (Cirrus HD-OCT 5000 Carl Zeiss, Germany), with a scanning range 
      of 3 mm x 3 mm. We divided the images into two concentric circles with diameters 
      of 1 mm and 3 mm at the macular fovea's center. Patients with PD were evaluated 
      during their "off" phase using the Unified Parkinson's Disease Rating Scale III 
      (UPDRS-III) and the Hoehn-Yahr scale (H-Y scale) to assess disease severity. 
      RESULTS: The PD group exhibited significantly lower RNFL thickness (106.13+/-12.36 
      mum) compared to the control group (115.95+/-11.37 mum, P < 0.05). Similarly, the 
      superficial retinal vessel length density was significantly lower in the PD group 
      (20.7 [19.62, 22.17] mm(-1)) than in the control group (21.79+/-1.16 mm(-1), P < 
      0.05). Correlation analysis revealed a negative correlation between RNFL 
      thickness and UPDRS III score (r(s)=-0.036, P=0.037), and RNFL thickness tended 
      to decrease with increasing severity of movement disorders. However, during the 6 
      and 12-month follow-up of some PD patients, we observed no progressive thinning 
      of the RNFL or decreased superficial vascular density. CONCLUSION: PD patients 
      show retinal structural damage characterized by RNFL thinning and reduced retinal 
      vessel length density. However, RNFL thickness did not correlate with vascular 
      density nor did it decrease with the disease's progression.
CI  - (c) 2023 Tu et al.
FAU - Tu, Min
AU  - Tu M
AD  - People's Hospital of Deyang City, Department of Neurology, Deyang, People's 
      Republic of China.
AD  - Affiliated Hospital of North Sichuan Medical College, Department of Neurology, 
      Nanchong, People's Republic of China.
FAU - Yang, Shuangfeng
AU  - Yang S
AD  - People's Hospital of Yuechi County, Department of Neurology, Guangan, People's 
      Republic of China.
FAU - Zeng, Lan
AU  - Zeng L
AD  - Affiliated Hospital of North Sichuan Medical College, Department of Neurology, 
      Nanchong, People's Republic of China.
FAU - Tan, Yuling
AU  - Tan Y
AD  - Affiliated Hospital of North Sichuan Medical College, Department of Neurology, 
      Nanchong, People's Republic of China.
FAU - Wang, Xiaoming
AU  - Wang X
AD  - Affiliated Hospital of North Sichuan Medical College, Department of Neurology, 
      Nanchong, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230822
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC10460207
OTO - NOTNLM
OT  - Parkinson disease
OT  - optical coherence
OT  - retina
OT  - tomography
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/28 06:41
MHDA- 2023/08/28 06:42
PMCR- 2023/08/22
CRDT- 2023/08/28 04:52
PHST- 2023/06/29 00:00 [received]
PHST- 2023/08/14 00:00 [accepted]
PHST- 2023/08/28 06:42 [medline]
PHST- 2023/08/28 06:41 [pubmed]
PHST- 2023/08/28 04:52 [entrez]
PHST- 2023/08/22 00:00 [pmc-release]
AID - 426501 [pii]
AID - 10.2147/IJGM.S426501 [doi]
PST - epublish
SO  - Int J Gen Med. 2023 Aug 22;16:3701-3712. doi: 10.2147/IJGM.S426501. eCollection 
      2023.