PMID- 37639046
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231121
IS  - 2192-2195 (Print)
IS  - 2192-2209 (Electronic)
IS  - 2192-2209 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Aug 28
TI  - Two pyrrole acids isolated from Phyllanthus emblica L. and their bioactivities.
PG  - 26
LID - 10.1007/s13659-023-00393-0 [doi]
LID - 26
AB  - An undescribed pyrrole acid, 
      1-(4'-methoxy-4'-oxobutyl)-1 H-pyrrole-2,5-dicarboxylic acid (1) and one known 
      pyrrole acid (2) were isolated from the fruits of Phyllanthus emblica. The 
      structures of these compounds were elucidated via the comprehensive analyses of 
      IR, HRESIMS, 1D and 2D spectroscopic data. A series of biological assays revealed 
      that compounds 1 and 2 could inhibit LPS-induced over-production of nitric oxide 
      (NO), interleukin-6 (IL-6), monocyte chemotactic protein 1 (MCP-1) and tumor 
      necrosis factor-alpha (TNF-alpha) by reducing the phosphorylation of extracellular 
      regulated protein kinases (ERK) and c-Jun N-terminal kinases (JNK) in RAW 264.7 
      cells. Additionally, compounds 1 and 2 were found to reduce lipid deposition and 
      increase the mRNA expression of ATP-binding cassette transporter A1 in oxidized 
      low-density lipoprotein-treated RAW264.7 macrophages.
CI  - (c) 2023. Kunming Institute of Botany, CAS.
FAU - Wang, Shu-Hui
AU  - Wang SH
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China.
FAU - Guo, Cong
AU  - Guo C
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China.
FAU - Cui, Wen-Jin
AU  - Cui WJ
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China.
FAU - Xu, Qing-Xia
AU  - Xu QX
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China.
FAU - Jiang, Jin-Zhu
AU  - Jiang JZ
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China.
FAU - Liu, Yan
AU  - Liu Y
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China.
FAU - Chen, Sha
AU  - Chen S
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China.
FAU - Chen, Chang
AU  - Chen C
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China.
FAU - Cheng, Jin-Tang
AU  - Cheng JT
AUID- ORCID: 0000-0001-7872-754X
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China. jtcheng@icmm.ac.cn.
FAU - Liu, An
AU  - Liu A
AD  - Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 
      Beijing, 100700, China. la62@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230828
PL  - Germany
TA  - Nat Prod Bioprospect
JT  - Natural products and bioprospecting
JID - 101577734
PMC - PMC10462542
OTO - NOTNLM
OT  - ATP-binding cassette transporter A1
OT  - Lipid deposition
OT  - Phyllanthus emblica L.
OT  - Pyrrole acid
OT  - RAW264.7 macrophages
COIS- The authors declare that there are no competing interests associated with this 
      work.
EDAT- 2023/08/28 12:43
MHDA- 2023/08/28 12:44
PMCR- 2023/08/28
CRDT- 2023/08/28 11:06
PHST- 2023/06/22 00:00 [received]
PHST- 2023/08/21 00:00 [accepted]
PHST- 2023/08/28 12:44 [medline]
PHST- 2023/08/28 12:43 [pubmed]
PHST- 2023/08/28 11:06 [entrez]
PHST- 2023/08/28 00:00 [pmc-release]
AID - 10.1007/s13659-023-00393-0 [pii]
AID - 393 [pii]
AID - 10.1007/s13659-023-00393-0 [doi]
PST - epublish
SO  - Nat Prod Bioprospect. 2023 Aug 28;13(1):26. doi: 10.1007/s13659-023-00393-0.