PMID- 37639099
OWN - NLM
STAT- Publisher
LR  - 20230930
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 45
DP  - 2023 Sep
TI  - The associations of non-essential metal mixture with fasting plasma glucose among 
      Chinese older adults without diabetes.
PG  - 100613-100625
LID - 10.1007/s11356-023-29503-8 [doi]
AB  - The evidence about the effect of non-essential metal mixture on fasting plasma 
      glucose (FPG) levels among older adults without diabetes is limited. This study 
      aims to estimate the individual and joint relationship between five non-essential 
      metals and FPG levels in Chinese older adults without diabetes. This study 
      included 2362 older adults without diabetes. Urinary concentrations of five 
      non-essential metals, i.e., cesium (Cs), aluminum (Al), thallium (Tl), cadmium 
      (Cd), and arsenic (As), were detected by inductively coupled plasma mass 
      spectrometry (ICP-MS). The associations of single metals and the metal mixture 
      with FPG levels were assessed using linear regression and Bayesian kernel machine 
      regression (BKMR) models, respectively. Adjusted single-metal linear regression 
      models showed positive associations of urinary Al (beta = 0.016, 95%CI: 0.001-0.030) 
      and Cs (beta = 0.018, 95%CI: 0.006-0.031) with FPG levels. When comparing the 2th, 
      3th, and 4th quartiles of urine Cs to its 1th quartile, the significant 
      associations between Cs and FPG levels were found and presented as an "inverted 
      U" trend (beta(Q2 vs. Q1): 0.034; beta(Q3 vs. Q1):0.054; beta(Q4 vs. Q1): 0.040; all 
      P<0.05). BKMR analyses showed urinary level of Cs exhibited an "inverted U" shape 
      association with FPG levels. Moreover, the FPG levels increased linearly with the 
      raised levels of the non-essential metal mixture, and the posterior inclusion 
      probability (PIP) of Cs was the highest (0.92). Potential positive interaction of 
      As and Cs on FPG levels was found in BKMR model. Stratified analysis displayed 
      significant interactions of hyperlipidemia and urine Cs or Tl on FPG levels. An 
      inverse U-shaped association between Cs and FPG was found, individually and as 
      mixture. The FPG levels increased with the raised levels of the non-essential 
      metal mixture, and Cs was the most contributor to FPG levels. Further research is 
      required to confirm the correlation between non-essential metals and FPG levels 
      and to clarify the underlying mechanisms.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Lei, Jing-Yuan
AU  - Lei JY
AD  - School of Public Health, Department of Hygiene Inspection and Quarantine, Anhui 
      Medical University, Hefei, 230032, Anhui, China.
FAU - Wang, Pan-Pan
AU  - Wang PP
AD  - School of Public Health, Department of Hygiene Inspection and Quarantine, Anhui 
      Medical University, Hefei, 230032, Anhui, China.
FAU - Wang, Hong-Li
AU  - Wang HL
AD  - School of Public Health, Department of Epidemiology and Health Statistics, Anhui 
      Medical University, Hefei, 230032, Anhui, China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - School of Public Health, Department of Epidemiology and Health Statistics, Anhui 
      Medical University, Hefei, 230032, Anhui, China.
FAU - Sun, Liang
AU  - Sun L
AD  - Fuyang Center for Diseases Prevention and Control, Fuyang, 236069, Anhui, China.
FAU - Hu, Bing
AU  - Hu B
AD  - Fuyang Center for Diseases Prevention and Control, Fuyang, 236069, Anhui, China.
FAU - Wang, Su-Fang
AU  - Wang SF
AD  - School of Public Health, Department of Nutrition and Food Hygiene, Anhui Medical 
      University, Hefei, 230032, Anhui, China.
FAU - Zhang, Dong-Mei
AU  - Zhang DM
AD  - School of Health Services Management, Anhui Medical University, Hefei, 230032, 
      Anhui, China.
FAU - Chen, Gui-Mei
AU  - Chen GM
AD  - School of Health Services Management, Anhui Medical University, Hefei, 230032, 
      Anhui, China.
FAU - Liang, Chun-Mei
AU  - Liang CM
AD  - School of Public Health, Department of Hygiene Inspection and Quarantine, Anhui 
      Medical University, Hefei, 230032, Anhui, China.
FAU - Tao, Fang-Biao
AU  - Tao FB
AD  - MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Yang, Lin-Sheng
AU  - Yang LS
AD  - School of Public Health, Department of Epidemiology and Health Statistics, Anhui 
      Medical University, Hefei, 230032, Anhui, China.
FAU - Wu, Qing-Si
AU  - Wu QS
AUID- ORCID: 0000-0001-9860-2664
AD  - Department of Blood Transfusion, the Second Affiliated Hospital of Anhui Medical 
      University, Hefei, 230601, Anhui, China. wuqingsi@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230828
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
SB  - IM
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Diabetes mellitus
OT  - Fasting plasma glucose
OT  - Metals
OT  - Mixture
OT  - Older adults
EDAT- 2023/08/28 12:42
MHDA- 2023/08/28 12:42
CRDT- 2023/08/28 11:08
PHST- 2023/05/11 00:00 [received]
PHST- 2023/08/22 00:00 [accepted]
PHST- 2023/08/28 12:42 [pubmed]
PHST- 2023/08/28 12:42 [medline]
PHST- 2023/08/28 11:08 [entrez]
AID - 10.1007/s11356-023-29503-8 [pii]
AID - 10.1007/s11356-023-29503-8 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Sep;30(45):100613-100625. doi: 
      10.1007/s11356-023-29503-8. Epub 2023 Aug 28.