PMID- 37640104
OWN - NLM
STAT- MEDLINE
DCOM- 20231128
LR  - 20240205
IS  - 1535-7732 (Electronic)
IS  - 1051-0443 (Linking)
VI  - 34
IP  - 12
DP  - 2023 Dec
TI  - Genicular Artery Embolization for Treatment of Knee Osteoarthritis: Interim 
      Analysis of a Prospective Pilot Trial Including Effect on Serum 
      Osteoarthritis-Associated Biomarkers.
PG  - 2180-2189.e3
LID - S1051-0443(23)00641-3 [pii]
LID - 10.1016/j.jvir.2023.08.029 [doi]
AB  - PURPOSE: To characterize the safety, efficacy, and potential role of genicular 
      artery embolization (GAE) as a disease-modifying treatment for symptomatic knee 
      osteoarthritis (OA). MATERIALS AND METHODS: This is an interim analysis of a 
      prospective, single-arm clinical trial of patients with symptomatic knee OA who 
      failed conservative therapy for greater than 3 months. Sixteen patients who 
      underwent GAE using 250-mum microspheres and had at least 1 month of follow-up 
      were included. Six patients completed the 12-month follow-up, and 10 patients 
      remain enrolled. Western Ontario and McMaster Universities Osteoarthritis Index 
      (WOMAC) was evaluated at baseline and at 1, 3, and 12 months. Serum and plasma 
      samples were collected for biomarker analysis. The primary end point was the 
      percentage of patients who achieved the minimal clinically important difference 
      (MCID) for WOMAC pain score at 12 months. Baseline and follow-up outcomes were 
      analyzed using the Wilcoxon matched-pairs signed-rank test. RESULTS: Technical 
      success of the procedure was 100%, with no major adverse events. The MCID was 
      achieved in 5 of the 6 (83%) patients at 12 months. The mean WOMAC pain score 
      decreased from 8.6 +/- 2.7 at baseline to 4.9 +/- 2.7 (P = .001), 4.4 +/- 2.8 (P < 
      .001), and 4.7 +/- 2.7 (P = .094) at 1, 3, and 12 months, respectively. There was a 
      statistically significant decrease in nerve growth factor (NGF) levels at 12 
      months. The remaining 8 biomarkers showed no significant change at 12 months. 
      CONCLUSIONS: GAE is a safe and efficacious treatment for symptomatic knee OA. 
      Decreased NGF levels after GAE may contribute to pain reduction and slowing of 
      cartilage degeneration.
CI  - Copyright (c) 2023 SIR. Published by Elsevier Inc. All rights reserved.
FAU - Taslakian, Bedros
AU  - Taslakian B
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, New York. Electronic address: 
      bedros.taslakian@nyulangone.org.
FAU - Swilling, David
AU  - Swilling D
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, New York.
FAU - Attur, Mukundan
AU  - Attur M
AD  - Division of Rheumatology, Department of Medicine, NYU Langone Health, New York, 
      New York.
FAU - Alaia, Erin F
AU  - Alaia EF
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, New York; Division of Musculoskeletal Imaging, 
      Department of Radiology, NYU Langone Health, New York, New York.
FAU - Kijowski, Richard
AU  - Kijowski R
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, New York; Division of Musculoskeletal Imaging, 
      Department of Radiology, NYU Langone Health, New York, New York.
FAU - Samuels, Jonathan
AU  - Samuels J
AD  - Division of Rheumatology, Department of Medicine, NYU Langone Health, New York, 
      New York.
FAU - Macaulay, William
AU  - Macaulay W
AD  - Department of Orthopedic Surgery, NYU Langone Health, New York, New York.
FAU - Ramos, Danibel
AU  - Ramos D
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, New York.
FAU - Liu, Shu
AU  - Liu S
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, New York.
FAU - Morris, Elizabeth M
AU  - Morris EM
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, New York.
FAU - Hickey, Ryan
AU  - Hickey R
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, New York.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230826
PL  - United States
TA  - J Vasc Interv Radiol
JT  - Journal of vascular and interventional radiology : JVIR
JID - 9203369
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Humans
MH  - *Osteoarthritis, Knee/diagnostic imaging/therapy
MH  - Prospective Studies
MH  - Pilot Projects
MH  - Nerve Growth Factor/therapeutic use
MH  - Treatment Outcome
MH  - Pain
EDAT- 2023/08/29 00:41
MHDA- 2023/11/28 06:42
CRDT- 2023/08/28 19:20
PHST- 2023/04/19 00:00 [received]
PHST- 2023/08/16 00:00 [revised]
PHST- 2023/08/19 00:00 [accepted]
PHST- 2023/11/28 06:42 [medline]
PHST- 2023/08/29 00:41 [pubmed]
PHST- 2023/08/28 19:20 [entrez]
AID - S1051-0443(23)00641-3 [pii]
AID - 10.1016/j.jvir.2023.08.029 [doi]
PST - ppublish
SO  - J Vasc Interv Radiol. 2023 Dec;34(12):2180-2189.e3. doi: 
      10.1016/j.jvir.2023.08.029. Epub 2023 Aug 26.