PMID- 37641013
OWN - NLM
STAT- MEDLINE
DCOM- 20230831
LR  - 20231123
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 23
IP  - 1
DP  - 2023 Aug 28
TI  - Changes in brain functional networks in remitted major depressive disorder: a 
      six-month follow-up study.
PG  - 628
LID - 10.1186/s12888-023-05082-3 [doi]
LID - 628
AB  - BACKGROUND: Patients with remitted major depressive disorder (rMDD) show abnormal 
      functional connectivity of the central executive network (CEN), salience networks 
      (SN) and default mode network (DMN). It is unclear how these change during 
      remission, or whether changes are related to function. METHODS: Three spatial 
      networks in 17 patients with rMDD were compared between baseline and the 
      six-month follow-up, and to 22 healthy controls. Correlations between these 
      changes and psychosocial functioning were also assessed. RESULTS: In the CEN, 
      patients at baseline had abnormal functional connectivity in the right anterior 
      cingulate, right dorsolateral prefrontal cortex (DLPFC) and inferior parietal 
      lobule (IPL) compare with HCs. There were functional connection differences in 
      the right DLPFC and left IPL at baseline during follow-up. Abnormal connectivity 
      in the right DLPFC and medial prefrontal cortex (mPFC) were found at follow-up. 
      In the SN, patients at baseline had abnormal functional connectivity in the 
      insula, left anterior cingulate, left IPL, and right precuneus; compared with 
      baseline, patients had higher connectivity in the right DLPFC at follow-up. In 
      the DMN, patients at baseline had abnormal functional connectivity in the right 
      mPFC. Resting-state functional connectivity of the IPL and DLPFC in the CEN 
      correlated with psychosocial functioning. CONCLUSIONS: At six-month follow-up, 
      the CEN still showed abnormal functional connectivity in those with rMDD, while 
      anomalies in the SN and DMN has disappeared. Resting-state functional 
      connectivity of the CEN during early rMDD is associated with psychosocial 
      function. CLINICAL TRIALS REGISTRATION: Pharmacotherapy and Psychotherapy for MDD 
      after Remission on Psychology and Neuroimaging. https://www. CLINICALTRIALS: gov/ 
      , registration number: NCT01831440 (15/4/2013).
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Zhong, Jiaqi
AU  - Zhong J
AD  - Affiliated Nanjing Brain Hospital of Nanjing Medical University, No.264 Guangzhou 
      Street, Gulou District, Nanjing, 210029, Jiangsu, China.
AD  - Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, 
      210029, Jiangsu, China.
FAU - Xu, Jingren
AU  - Xu J
AD  - Affiliated Nanjing Brain Hospital of Nanjing Medical University, No.264 Guangzhou 
      Street, Gulou District, Nanjing, 210029, Jiangsu, China.
FAU - Wang, Zhenzhen
AU  - Wang Z
AD  - Affiliated Nanjing Brain Hospital of Nanjing Medical University, No.264 Guangzhou 
      Street, Gulou District, Nanjing, 210029, Jiangsu, China.
AD  - School of psychological and cognitive sciences, Peking University, Beijing, 
      100871, China.
FAU - Yang, Hao
AU  - Yang H
AD  - Affiliated Nanjing Brain Hospital of Nanjing Medical University, No.264 Guangzhou 
      Street, Gulou District, Nanjing, 210029, Jiangsu, China.
FAU - Li, Jiawei
AU  - Li J
AD  - Affiliated Nanjing Brain Hospital of Nanjing Medical University, No.264 Guangzhou 
      Street, Gulou District, Nanjing, 210029, Jiangsu, China.
FAU - Yu, Haoran
AU  - Yu H
AD  - Affiliated Nanjing Brain Hospital of Nanjing Medical University, No.264 Guangzhou 
      Street, Gulou District, Nanjing, 210029, Jiangsu, China.
FAU - Huang, Wenyan
AU  - Huang W
AD  - Affiliated Nanjing Brain Hospital of Nanjing Medical University, No.264 Guangzhou 
      Street, Gulou District, Nanjing, 210029, Jiangsu, China.
FAU - Wan, Cheng
AU  - Wan C
AD  - Department of Medical Informatic, School of Biomedical Engineering and 
      Informatics, Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
FAU - Ma, Hui
AU  - Ma H
AD  - Affiliated Nanjing Brain Hospital of Nanjing Medical University, No.264 Guangzhou 
      Street, Gulou District, Nanjing, 210029, Jiangsu, China. mahui@njmu.edu.cn.
FAU - Zhang, Ning
AU  - Zhang N
AD  - Affiliated Nanjing Brain Hospital of Nanjing Medical University, No.264 Guangzhou 
      Street, Gulou District, Nanjing, 210029, Jiangsu, China. zn6360@126.com.
AD  - Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, 
      210029, Jiangsu, China. zn6360@126.com.
AD  - Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, 
      210029, Jiangsu, China. zn6360@126.com.
LA  - eng
SI  - ClinicalTrials.gov/NCT01831440
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230828
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
SB  - IM
MH  - Humans
MH  - Brain/diagnostic imaging
MH  - Case-Control Studies
MH  - *Depressive Disorder, Major/diagnostic imaging/therapy
MH  - Follow-Up Studies
MH  - Gyrus Cinguli/diagnostic imaging
MH  - Prefrontal Cortex/diagnostic imaging
PMC - PMC10464087
OTO - NOTNLM
OT  - Central executive network
OT  - Default mode network
OT  - Psychosocial functioning
OT  - Remitted major depressive disorder
OT  - Salience network
COIS- The authors declare no competing interests.
EDAT- 2023/08/29 00:42
MHDA- 2023/08/31 06:42
PMCR- 2023/08/28
CRDT- 2023/08/28 23:35
PHST- 2022/12/09 00:00 [received]
PHST- 2023/08/06 00:00 [accepted]
PHST- 2023/08/31 06:42 [medline]
PHST- 2023/08/29 00:42 [pubmed]
PHST- 2023/08/28 23:35 [entrez]
PHST- 2023/08/28 00:00 [pmc-release]
AID - 10.1186/s12888-023-05082-3 [pii]
AID - 5082 [pii]
AID - 10.1186/s12888-023-05082-3 [doi]
PST - epublish
SO  - BMC Psychiatry. 2023 Aug 28;23(1):628. doi: 10.1186/s12888-023-05082-3.