PMID- 37641229
OWN - NLM
STAT- MEDLINE
DCOM- 20230831
LR  - 20230903
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 44
IP  - 5
DP  - 2023 Sep 1
TI  - Relationship between autoimmune diseases and serum basal immunoglobulin E levels 
      in patients with common variable immunodeficiency.
PG  - e11-e16
LID - 10.2500/aap.2023.44.230025 [doi]
AB  - Background: Autoimmune diseases can occur at any time in patients with common 
      variable immunodeficiency (CVID). However, the relationship between low 
      immunoglobulin E (IgE) levels and autoimmune diseases in patients with CVID 
      remains poorly understood. Objective: We aimed to determine the relationship 
      between autoimmunity and low IgE in patients with CVID. Methods: This 
      retrospective cohort study was conducted by using data that had been collected 
      from 62 adult patients with CVID between April 2012 and December 2021. Serum 
      basal IgE levels were compared between patients with and patients without 
      autoimmune disease. Results: Overall, 23 of the 62 patients with CVID (37.1%) had 
      at least one autoimmune disease (CVID-O). Autoimmune cytopenias, mainly immune 
      thrombocytopenic purpura, were observed in half of all the patients. Other 
      autoimmune diseases present among the patients included rheumatological diseases, 
      inflammatory bowel diseases, lymphoma, granulomatous lymphocytic interstitial 
      lung disease, autoimmune hepatitis, alopecia, and multiple sclerosis. Serum IgE 
      levels were measured at the time of diagnosis; IgE was undetectable (<2.5 IU/mL) 
      in 82.6% of the patients with CVID-O (n = 19). The median (interquartile range) 
      serum IgE value in the patients with CVID-O was 2 IU/mL (1-16 IU/mL), which was 
      significantly lower than the median serum IgE value in patients with CVID and 
      without autoimmune disease (p < 0.001). Low IgE levels in patients with CVID-O 
      were an independent risk factor for the development of autoimmune disease in 
      patients with CVID (odds ratio 3.081 [95% confidence interval, 1.222-7.771]; 
      p = 0.017). Conclusion: Low serum IgE levels were associated with the development 
      of autoimmune disease in patients with CVID. The monitoring of serum IgE levels 
      in patients with CVID may be useful in the early diagnosis and treatment of 
      autoimmune diseases.
FAU - Kilinc, Mehmet
AU  - Kilinc M
AD  - From the Division of Clinical Immunology and Allergy, Department of Internal 
      Medicine, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey, 
      and.
FAU - Colkesen, Fatih
AU  - Colkesen F
AD  - From the Division of Clinical Immunology and Allergy, Department of Internal 
      Medicine, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey, 
      and.
FAU - Evcen, Recep
AU  - Evcen R
AD  - From the Division of Clinical Immunology and Allergy, Department of Internal 
      Medicine, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey, 
      and.
FAU - Sadi Aykan, Filiz
AU  - Sadi Aykan F
AD  - From the Division of Clinical Immunology and Allergy, Department of Internal 
      Medicine, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey, 
      and.
FAU - Yildiz, Eray
AU  - Yildiz E
AD  - Division of Clinical Immunology and Allergy, Necip Fazil City Hospital, 
      Kahramanmaras, Turkey.
FAU - Onalan, Tugba
AU  - Onalan T
AD  - From the Division of Clinical Immunology and Allergy, Department of Internal 
      Medicine, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey, 
      and.
FAU - Yilmaz Ergun, Ummugulsum
AU  - Yilmaz Ergun U
AD  - From the Division of Clinical Immunology and Allergy, Department of Internal 
      Medicine, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey, 
      and.
FAU - Akkus, Fatma Arzu
AU  - Akkus FA
AD  - From the Division of Clinical Immunology and Allergy, Department of Internal 
      Medicine, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey, 
      and.
FAU - Arslan, Sevket
AU  - Arslan S
AD  - From the Division of Clinical Immunology and Allergy, Department of Internal 
      Medicine, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey, 
      and.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Common Variable Immunodeficiency/diagnosis/epidemiology
MH  - Retrospective Studies
MH  - *Autoimmune Diseases/diagnosis/epidemiology
MH  - Autoimmunity
MH  - Immunoglobulin E
EDAT- 2023/08/29 06:43
MHDA- 2023/08/31 06:41
CRDT- 2023/08/29 00:43
PHST- 2023/08/31 06:41 [medline]
PHST- 2023/08/29 06:43 [pubmed]
PHST- 2023/08/29 00:43 [entrez]
AID - 10.2500/aap.2023.44.230025 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2023 Sep 1;44(5):e11-e16. doi: 10.2500/aap.2023.44.230025.