PMID- 37642204
OWN - NLM
STAT- MEDLINE
DCOM- 20230925
LR  - 20230926
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 45
IP  - 10
DP  - 2023 Oct
TI  - The impact of undergoing surgical margin evaluation during endoscopic surgery for 
      early-stage laryngeal squamous cell carcinoma.
PG  - 2680-2689
LID - 10.1002/hed.27493 [doi]
AB  - BACKGROUND: The impact of evaluating versus not evaluating surgical margins for 
      early-stage laryngeal squamous cell carcinoma (LSCC) has not been evaluated. 
      METHODS: Overall survival was compared between patients who underwent endoscopic 
      surgery for cT1-2, N0, M0 LSCC and had surgical margins evaluated versus not 
      evaluated versus unevaluable in the National Cancer Database (2010-2019) using 
      multivariable-adjusted Cox proportional hazards analyses. RESULTS: 7597 patients 
      met study eligibility criteria. 4123 (54.3%) patients underwent margin 
      evaluation, 1631 (21.5%) did not undergo margin evaluation, and 1843 (24.3%) had 
      unevaluable margins. Patients undergoing margin evaluation had better overall 
      survival than patients who did not undergo margin evaluation (HR: 0.88, 95% CI: 
      0.78-1.00, p = 0.044) and patients with unevaluable margins (HR: 0.88, 95% CI: 
      0.78-0.98, p = 0.021). Patients undergoing margin evaluation received 
      significantly less adjuvant radiation. CONCLUSIONS: Surgical margin evaluation is 
      an important prognostic factor for patients receiving endoscopic surgery for 
      early-stage LSCC and should be conducted whenever possible.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Gilja, Shivee
AU  - Gilja S
AUID- ORCID: 0000-0001-5574-8620
AD  - Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at 
      Mount Sinai, New York, New York, USA.
FAU - Kumar, Arvind
AU  - Kumar A
AD  - Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at 
      Mount Sinai, New York, New York, USA.
FAU - Vasan, Vikram
AU  - Vasan V
AUID- ORCID: 0000-0003-2754-4107
AD  - Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at 
      Mount Sinai, New York, New York, USA.
FAU - Roof, Scott A
AU  - Roof SA
AD  - Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at 
      Mount Sinai, New York, New York, USA.
FAU - Genden, Eric M
AU  - Genden EM
AD  - Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at 
      Mount Sinai, New York, New York, USA.
FAU - Kirke, Diana N
AU  - Kirke DN
AD  - Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at 
      Mount Sinai, New York, New York, USA.
LA  - eng
PT  - Journal Article
DEP - 20230829
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Humans
MH  - *Margins of Excision
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Endoscopy
MH  - Databases, Factual
MH  - *Head and Neck Neoplasms
OTO - NOTNLM
OT  - LSCC
OT  - endoscopic surgery
OT  - laryngeal cancer
OT  - surgical margin evaluation
OT  - surgical margin status
EDAT- 2023/08/29 12:44
MHDA- 2023/09/25 06:42
CRDT- 2023/08/29 07:03
PHST- 2023/07/19 00:00 [revised]
PHST- 2023/05/14 00:00 [received]
PHST- 2023/08/14 00:00 [accepted]
PHST- 2023/09/25 06:42 [medline]
PHST- 2023/08/29 12:44 [pubmed]
PHST- 2023/08/29 07:03 [entrez]
AID - 10.1002/hed.27493 [doi]
PST - ppublish
SO  - Head Neck. 2023 Oct;45(10):2680-2689. doi: 10.1002/hed.27493. Epub 2023 Aug 29.