PMID- 37644801
OWN - NLM
STAT- MEDLINE
DCOM- 20240131
LR  - 20240206
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 40
IP  - 1
DP  - 2024 Jan
TI  - Elevated circulating follicle stimulating hormone level is associated with 
      dyslipidemia in male type 2 diabetes mellitus patients: A cross-sectional study.
PG  - e3718
LID - 10.1002/dmrr.3718 [doi]
AB  - AIMS: Type 2 diabetes mellitus (T2DM) commonly combines with dyslipidemia, and 
      both are known as the risk factors of cardiovascular events and aggravate the 
      arteriosclerosis progression. In this study, we investigated the relationship 
      between follicle-stimulating hormone (FSH) and lipid profiles in male T2DM 
      patients. MATERIALS AND METHODS: We collected clinical data of male T2DM patients 
      in the Chinese Han population hospitalised from January 2018 to June 2020. A 
      total of 963 patients with a mean age of 58.89 +/- 12.25 years old were enroled in 
      this study. RESULTS: The results showed that the levels of total cholesterol 
      (TC), triglyceride (TG), and low-density lipoprotein (LDL)-C levels were 
      decreased gradually from the highest quartile groups (Q4) to Q1 group relevant to 
      luteinising hormone and FSH, and no significant difference was observed in 
      high-density lipoprotein-C levels among Q4-Q1 groups. Sub-groups analysis showed 
      that, with the increased FSH level, TC, TG, and LDL-C levels were increased in 
      the elder group (40-59 years old) than those in the younger group (20-39 years 
      old). Spearman's analysis revealed a positive correlation between FSH and the 
      levels of TC, TG, and LDL-C (r = 0.354, r = 0.336, r = 0.312, p < 0.001, 
      respectively). The effect of FSH is independent of the changes in total 
      testosterone level. Multivariate analysis found that increased FSH levels 
      (>/=9.26 mIU/mL) and decreased total testosterone levels (<13.30 nmol/L) were 
      positively correlated with high TC, TG, and LDL-Cemia (OR = 4.014, 1.565, 1.602, 
      1.660, 2.127, 1.322, respectively, p < 0.05). CONCLUSIONS: Our data suggest that 
      high serum FSH level in male T2DM patients could be a potential independent risk 
      factor correlated with the elevated TC, TG, and LDL-C.
CI  - (c) 2023 John Wiley & Sons Ltd.
FAU - Xu, Xiang
AU  - Xu X
AD  - Department of International Medical Center, The Affiliated Hospital of Qingdao 
      University, Qingdao, China.
FAU - Li, Chengqian
AU  - Li C
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Diao, Hongcui
AU  - Diao H
AUID- ORCID: 0000-0003-1421-5806
AD  - Department of Endocrinology, Jinan Central Hospital, Shandong University, Jinan, 
      China.
FAU - Guo, Yanjun
AU  - Guo Y
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Zhao, Yuhang
AU  - Zhao Y
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Zhao, Wenjuan
AU  - Zhao W
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Dong, Bingzi
AU  - Dong B
AUID- ORCID: 0000-0003-2446-0725
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
LA  - eng
GR  - 82370890/National Natural Science Foundation of China/
GR  - 2018M640615/China Postdoctoral Science Foundation funded project/
PT  - Journal Article
DEP - 20230829
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Triglycerides)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - 3XMK78S47O (Testosterone)
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Aged
MH  - Adult
MH  - Young Adult
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Cross-Sectional Studies
MH  - Cholesterol, LDL
MH  - Triglycerides
MH  - Follicle Stimulating Hormone
MH  - *Dyslipidemias/complications
MH  - Testosterone
MH  - Cholesterol, HDL
OTO - NOTNLM
OT  - T2DM
OT  - cross-sectional study
OT  - follicle stimulating hormone (FSH)
OT  - lipid metabolism
OT  - total testosterone
EDAT- 2023/08/30 06:48
MHDA- 2024/01/31 06:42
CRDT- 2023/08/30 02:53
PHST- 2023/07/03 00:00 [revised]
PHST- 2022/11/16 00:00 [received]
PHST- 2023/07/24 00:00 [accepted]
PHST- 2024/01/31 06:42 [medline]
PHST- 2023/08/30 06:48 [pubmed]
PHST- 2023/08/30 02:53 [entrez]
AID - 10.1002/dmrr.3718 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2024 Jan;40(1):e3718. doi: 10.1002/dmrr.3718. Epub 2023 
      Aug 29.