PMID- 37644819
OWN - NLM
STAT- MEDLINE
DCOM- 20230915
LR  - 20230922
IS  - 1759-9679 (Electronic)
IS  - 1759-9660 (Linking)
VI  - 15
IP  - 35
DP  - 2023 Sep 14
TI  - Efficient separation of aristolochic acid I from Caulis aristolochiae 
      manshuriensis (Guan-mu-tong) with copper mediated magnetic molecularly imprinted 
      polymer.
PG  - 4555-4562
LID - 10.1039/d3ay00920c [doi]
AB  - Screening bioactive compounds from natural products is one of the most effective 
      ways for new drug research and development. However, obtaining a single extract 
      component on a large scale and with high purity from a complex matrix is still an 
      arduous and challenging task. Herein, one metal mediated magnetic molecularly 
      imprinted polymer (mMIP) was rationally designed and prepared for specifically 
      capturing Aristolochic acid I (AAI). The preparation was done with copper(II) as 
      binding pivot, (3-aminopropyl) triethoxysilane as functional monomer, and 
      Fe(3)O(4) as core, by a one-step sol-gel method. Under the optimized conditions, 
      the apparent maximum binding amount of copper mediated mMIP (Cu-mMIP) reaches as 
      high as 349.72 mg g(-1), the highest among the reported AAI-MIPs. Moreover, the 
      nanoparticles exhibit excellent specificity and selectivity, good reproducibility 
      and stability, high superparamagnetism (60.32 emu g(-1)), and high imprinting 
      efficiency (an imprinting factor of 7). By simulating an industrial-scale 
      separation, 16.56 mg AAI (purity of 95.11%) is obtained after six cycles with 100 
      mg nanoparticles from 20 g Caulis aristolochiae manshuriensis (Guan-mu-tong). 
      Notably, this takes only 3 hours and consumes 50 mL of methanol. The study 
      provides a potent tool for the green, fast, and specific extraction of 
      high-purity ingredients from natural plants in the manufacturing industry and 
      conventional analysis in the lab.
FAU - Cao, Yu
AU  - Cao Y
AD  - Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, 
      School of Life Science and Engineering, Southwest Jiaotong University, China. 
      fengshunxd@hotmail.com.
FAU - Shi, Haizhu
AU  - Shi H
AD  - Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, 
      School of Life Science and Engineering, Southwest Jiaotong University, China. 
      fengshunxd@hotmail.com.
FAU - Lan, Zhuo
AU  - Lan Z
AD  - Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, 
      School of Life Science and Engineering, Southwest Jiaotong University, China. 
      fengshunxd@hotmail.com.
FAU - He, Kunlin
AU  - He K
AD  - Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, 
      School of Life Science and Engineering, Southwest Jiaotong University, China. 
      fengshunxd@hotmail.com.
FAU - Chen, Qian
AU  - Chen Q
AD  - Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, 
      School of Life Science and Engineering, Southwest Jiaotong University, China. 
      fengshunxd@hotmail.com.
FAU - Zhang, Chungu
AU  - Zhang C
AD  - Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, 
      School of Life Science and Engineering, Southwest Jiaotong University, China. 
      fengshunxd@hotmail.com.
FAU - Feng, Shun
AU  - Feng S
AUID- ORCID: 0000-0003-1602-0244
AD  - Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, 
      School of Life Science and Engineering, Southwest Jiaotong University, China. 
      fengshunxd@hotmail.com.
FAU - Shan, Lianhai
AU  - Shan L
AD  - Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, 
      School of Life Science and Engineering, Southwest Jiaotong University, China. 
      fengshunxd@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230914
PL  - England
TA  - Anal Methods
JT  - Analytical methods : advancing methods and applications
JID - 101519733
RN  - 789U1901C5 (Copper)
RN  - 94218WFP5T (aristolochic acid I)
RN  - 0 (Molecularly Imprinted Polymers)
RN  - L8S6UBW552 (amino-propyl-triethoxysilane)
SB  - IM
MH  - *Copper
MH  - Molecularly Imprinted Polymers
MH  - Reproducibility of Results
MH  - *Aristolochia
MH  - Magnetic Phenomena
EDAT- 2023/08/30 06:48
MHDA- 2023/09/15 06:42
CRDT- 2023/08/30 03:09
PHST- 2023/09/15 06:42 [medline]
PHST- 2023/08/30 06:48 [pubmed]
PHST- 2023/08/30 03:09 [entrez]
AID - 10.1039/d3ay00920c [doi]
PST - epublish
SO  - Anal Methods. 2023 Sep 14;15(35):4555-4562. doi: 10.1039/d3ay00920c.