PMID- 37645698
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230831
IS  - 2451-9936 (Electronic)
IS  - 2451-9936 (Linking)
VI  - 32
DP  - 2023 Dec
TI  - An unusual case of rapid resolution of bilateral vitelliform deposits after 
      discontinuation of pentosan polysulfate sodium.
PG  - 101875
LID - 10.1016/j.ajoc.2023.101875 [doi]
LID - 101875
AB  - PURPOSE: To report the structural and functional changes in a 67-year-old male 
      with pentosan polysulfate sodium (PPS) maculopathy with a progressive resolution 
      of bilateral vitelliform lesions after PPS cessation. OBSERVATIONS: The patient 
      was initially seen after taking daily PPS for over 26 years. Three months after 
      discontinuing PPS, the bilateral vitelliform lesions identified on 
      spectral-domain optical coherence tomography (SD-OCT) at initial consultation had 
      completely resolved. Bilateral resolution of vitelliform lesions was associated 
      with a decline in best-corrected visual acuity, and ellipsoid zone disruption on 
      SD-OCT. CONCLUSIONS AND IMPORTANCE: Several PPS maculopathy phenotypes have been 
      previously described including vitelliform lesions. Our case highlights that 
      discontinuing PPS may lead to rapid resolution of vitelliform lesions in PPS 
      maculopathy and may be associated with a rapid reduction in vision.
CI  - (c) 2023 The Author(s).
FAU - Kalaw, Fritz Gerald P
AU  - Kalaw FGP
AD  - Jacobs Retina Center, University of California San Diego, La Jolla, CA, 92093, 
      USA.
AD  - Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University 
      of California San Diego, La Jolla, CA, 92093, USA.
AD  - Division of Ophthalmology Informatics and Data Science, Viterbi Family Department 
      of Ophthalmology and Shiley Eye Institute, University of California San Diego, La 
      Jolla, CA, 92093, USA.
FAU - Scott, Nathan L
AU  - Scott NL
AD  - Jacobs Retina Center, University of California San Diego, La Jolla, CA, 92093, 
      USA.
AD  - Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University 
      of California San Diego, La Jolla, CA, 92093, USA.
FAU - Borooah, Shyamanga
AU  - Borooah S
AD  - Jacobs Retina Center, University of California San Diego, La Jolla, CA, 92093, 
      USA.
AD  - Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University 
      of California San Diego, La Jolla, CA, 92093, USA.
LA  - eng
PT  - Case Reports
DEP - 20230620
PL  - United States
TA  - Am J Ophthalmol Case Rep
JT  - American journal of ophthalmology case reports
JID - 101679941
PMC - PMC10461119
OTO - NOTNLM
OT  - Ellipsoid zone loss
OT  - Pentosan polysulfate sodium maculopathy
OT  - Pseudovitelliform lesion
OT  - Retinal pigment epithelium
OT  - Retinal toxicity
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/08/30 06:47
MHDA- 2023/08/30 06:48
PMCR- 2023/06/20
CRDT- 2023/08/30 03:58
PHST- 2023/03/07 00:00 [received]
PHST- 2023/05/11 00:00 [revised]
PHST- 2023/06/15 00:00 [accepted]
PHST- 2023/08/30 06:48 [medline]
PHST- 2023/08/30 06:47 [pubmed]
PHST- 2023/08/30 03:58 [entrez]
PHST- 2023/06/20 00:00 [pmc-release]
AID - S2451-9936(23)00083-X [pii]
AID - 101875 [pii]
AID - 10.1016/j.ajoc.2023.101875 [doi]
PST - epublish
SO  - Am J Ophthalmol Case Rep. 2023 Jun 20;32:101875. doi: 10.1016/j.ajoc.2023.101875. 
      eCollection 2023 Dec.