PMID- 37648095
OWN - NLM
STAT- MEDLINE
DCOM- 20231027
LR  - 20231112
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 136
DP  - 2023 Nov
TI  - Early-life surface colonization with multi-drug resistant organisms in the 
      neonatal intensive care unit.
PG  - 11-13
LID - S1201-9712(23)00701-4 [pii]
LID - 10.1016/j.ijid.2023.08.016 [doi]
AB  - OBJECTIVES: In this study, we aim to describe the patterns of early-life surface 
      colonization with multi-drug resistant (MDR) organisms (MDROs) among newborns 
      admitted to the neonatal intensive care unit (NICU). METHODS: We conducted a 
      retrospective descriptive study of infants with culture-positive external ear 
      surface swabs performed immediately after admission to our NICU from January 1, 
      2017 - December 31, 2021. Clinical characteristics, culture and antibiotic 
      susceptibility data were extracted from the department data collection and 
      hospital electronic databases. RESULTS: A total of 314 infants were included - 
      median 34 weeks gestation (interquartile range [IQR] 30, 38) and median 
      birthweight 2147 g (IQR 1470, 2875). Of the 379 bacterial isolates obtained, 259 
      (68.3%) were gram-negative with Escherichia coli (149/379, 39.3%) and Klebsiella 
      spp (57/379, 15.0%) the most common gram-negatives isolated. MDROs accounted for 
      17.4% (45/259) of gram-negative isolates. There was no methicillin-resistant 
      Staphylococcus aureus (0/22 isolates) or vancomycin-resistant Enterococcus (0/68) 
      detected among isolates tested. A total of 27 (8.6%) infants developed 
      bacteremia, of which 21/27 (77.8%) had concordant bacteria isolated from surface 
      cultures, with identical resistance patterns, and 4/21 (19.0%) isolates were 
      MDROs. CONCLUSION: In our setting where gram-negative bacteria accounted for a 
      high proportion of initial colonization, MDR gram-negatives accounted for up to 
      17% of colonizing gram-negative bacteria detected.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Loe, Marcus Wing Choy
AU  - Loe MWC
AD  - Department of Neonatology, KK Women's and Children's Hospital, Singapore; 
      Duke-NUS Medical School, Singapore.
FAU - Yeo, Kee Thai
AU  - Yeo KT
AD  - Department of Neonatology, KK Women's and Children's Hospital, Singapore; 
      Duke-NUS Medical School, Singapore; Yong Loo Lin School of Medicine, National 
      University of Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang 
      Technological University, Singapore. Electronic address: 
      yeo.kee.thai@singhealth.com.sg.
LA  - eng
PT  - Journal Article
DEP - 20230828
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Infant
MH  - Humans
MH  - Infant, Newborn
MH  - *Intensive Care Units, Neonatal
MH  - Retrospective Studies
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - Gram-Negative Bacteria
MH  - Enterococcus
MH  - Anti-Bacterial Agents/pharmacology/therapeutic use
MH  - Drug Resistance, Bacterial
MH  - Microbial Sensitivity Tests
OTO - NOTNLM
OT  - Antimicrobial drug resistance
OT  - Bacteremia
OT  - Multi-drug resistant organisms
OT  - Premature infant
COIS- Declarations of competing interest The authors have no competing interests to 
      declare.
EDAT- 2023/08/31 00:41
MHDA- 2023/10/27 06:42
CRDT- 2023/08/30 19:23
PHST- 2023/06/09 00:00 [received]
PHST- 2023/08/21 00:00 [revised]
PHST- 2023/08/22 00:00 [accepted]
PHST- 2023/10/27 06:42 [medline]
PHST- 2023/08/31 00:41 [pubmed]
PHST- 2023/08/30 19:23 [entrez]
AID - S1201-9712(23)00701-4 [pii]
AID - 10.1016/j.ijid.2023.08.016 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2023 Nov;136:11-13. doi: 10.1016/j.ijid.2023.08.016. Epub 2023 
      Aug 28.