PMID- 37648947
OWN - NLM
STAT- MEDLINE
DCOM- 20230926
LR  - 20230926
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 50
IP  - 10
DP  - 2023 Oct
TI  - The effects of alpha-pinene on the Nrf2-HO1 signaling pathway in gastric damage 
      in rats.
PG  - 8615-8622
LID - 10.1007/s11033-023-08765-y [doi]
AB  - BACKGROUND: Alpha-pinene (alpha-pinene) is a monoterpene with gastroprotective 
      activity. We evaluated the gastroprotective effect of alpha-pinene in the gastric 
      damage model with ethanol. METHODS: We evaluated the macroscopic evaluation of 
      the stomach cavity, alteration in pH, mRNA expression of nuclear factor erythroid 
      2- related factor 2 (Nrf2) and heme oxygenase-1 (HO-1), total antioxidant 
      capacity (TAC) levels, and histopathological changes. RESULTS: Pretreatment with 
      alpha-pinene (10, 50 and 100 mg/kg i.p.) before oral administration of ethanol 
      reduced gastric mucosal damage by increasing the percentage of ulcer inhibition. 
      Alpha-pinene also increased gastric pH similar to omeprazole. In addition, the 
      histopathological examination showed that in the groups pretreated with alpha-pinene 
      50 and 100 mg/kg, and omeprazole20 mg/kg, the lesions were less than the control 
      group. Moreover, alpha- pinene 10, 50, 100, and omeprazole 20 mg/kg upregulated the 
      NRF2 and HO1. CONCLUSIONS: Our results show that pretreatment with alpha-pinene is 
      effective in reducing ethanol-induced gastric damage through regulation of 
      Nrf2/HO-1.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Rahimi, Kaveh
AU  - Rahimi K
AUID- ORCID: 0000-0002-8674-3993
AD  - Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran 
      University of Ahvaz, Ahvaz, Iran. k.rahimi@scu.ac.ir.
FAU - Shirvani, Negin
AU  - Shirvani N
AD  - Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran 
      University of Ahvaz, Ahvaz, Iran.
FAU - Sanaie, Parham
AU  - Sanaie P
AD  - Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran 
      University of Ahvaz, Ahvaz, Iran.
FAU - Javadi, Arian
AU  - Javadi A
AD  - Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran 
      University of Ahvaz, Ahvaz, Iran.
FAU - Khademi, Mahsa
AU  - Khademi M
AD  - Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran 
      University of Ahvaz, Ahvaz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230831
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - JPF3YI7O34 (alpha-pinene)
RN  - 0 (NF-E2-Related Factor 2)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - 3K9958V90M (Ethanol)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Animals
MH  - Rats
MH  - *NF-E2-Related Factor 2
MH  - *Heme Oxygenase-1/genetics
MH  - Stomach
MH  - Signal Transduction
MH  - Ethanol
MH  - Omeprazole/pharmacology
OTO - NOTNLM
OT  - Gastric damage
OT  - HO1
OT  - Nrf2
OT  - alpha-pinene
EDAT- 2023/08/31 00:42
MHDA- 2023/09/26 13:42
CRDT- 2023/08/30 23:35
PHST- 2023/05/26 00:00 [received]
PHST- 2023/08/16 00:00 [accepted]
PHST- 2023/09/26 13:42 [medline]
PHST- 2023/08/31 00:42 [pubmed]
PHST- 2023/08/30 23:35 [entrez]
AID - 10.1007/s11033-023-08765-y [pii]
AID - 10.1007/s11033-023-08765-y [doi]
PST - ppublish
SO  - Mol Biol Rep. 2023 Oct;50(10):8615-8622. doi: 10.1007/s11033-023-08765-y. Epub 
      2023 Aug 31.