PMID- 37649097
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231120
IS  - 1710-1484 (Print)
IS  - 1710-1492 (Electronic)
IS  - 1710-1484 (Linking)
VI  - 19
IP  - 1
DP  - 2023 Aug 30
TI  - Correlations between IL-36 family cytokines in peripheral blood and subjective 
      and objective assessment results in patients with allergic rhinitis.
PG  - 79
LID - 10.1186/s13223-023-00834-y [doi]
LID - 79
AB  - BACKGROUND: Interleukin (IL)-36 family cytokines have received increasing 
      attention, especially in the fields of inflammation and immunity research. 
      However, whether IL-36 family cytokine levels are correlated with the results of 
      the assessment of allergic rhinitis (AR) and affect the severity of AR remains 
      unknown. Therefore, this study aimed to investigate the correlations between 
      IL-36 family cytokine levels and subjective and objective assessment results and 
      to further analyze the possible mechanisms of IL-36 family cytokines in the 
      development of AR. METHODS: An enzyme-linked immunosorbent assay (ELISA) was used 
      to detect the concentrations of the IL-36 family cytokines IL-36alpha, IL-36beta, 
      IL-36gamma, IL-36Ra, and IL-38 in the peripheral blood of patients with AR. The 
      condition of patients with AR was assessed by 22-item sino-nasal outcome test 
      (SNOT-22) score, visual analogue scale (VAS) scores for disease severity, and 
      serum inhalant allergen immunoglobulin E (IgE) detection. Correlations between 
      IL-36 family cytokine levels and subjective and objective assessment results in 
      patients with AR were analyzed. RESULTS: The concentration of IL-36alpha in the 
      peripheral blood of patients with AR was the highest, and the concentration of 
      IL-36beta was the lowest. The concentration of IL-36alpha was higher in juvenile 
      patients than in adult patients, and there was a difference in the IL-36Ra level 
      between the perennial allergen group and the seasonal allergen group. There was a 
      positive correlation between IL-36alpha level and IL-36gamma level, IL-36gamma level and 
      IL-36Ra level, and IL-36Ra level and IL-38 level, and IL-36beta level was positively 
      correlated with IL-36Ra and IL-38 levels, respectively. IL-36alpha level was 
      positively correlated with VAS score for nasal congestion symptom. IL-36beta level 
      was positively correlated with the total VAS score for ocular symptoms and VAS 
      scores for ocular itching and eye pain symptoms. However, there was no 
      correlation between the levels of all cytokines in IL-36 family and SNOT-22 
      score, the number of positive inhaled allergens, or the highest positive 
      intensity of allergen specific immunoglobulin E (sIgE). CONCLUSION: Peripheral 
      blood IL-36 family cytokines play an important role in AR, and the concentrations 
      of IL-36alpha and IL-36beta were related to the severity of symptoms in patients with 
      AR.
CI  - (c) 2023. Canadian Society of Allergy & Clinical Immunology.
FAU - Gu, Jia
AU  - Gu J
AD  - Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Taiping Street & NO. 25, Luzhou, 646000, Sichuan, 
      China.
FAU - Qin, Gang
AU  - Qin G
AD  - Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Taiping Street & NO. 25, Luzhou, 646000, Sichuan, 
      China.
FAU - Jiang, Liang
AU  - Jiang L
AD  - Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Taiping Street & NO. 25, Luzhou, 646000, Sichuan, 
      China.
FAU - Xu, Wei
AU  - Xu W
AD  - Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Taiping Street & NO. 25, Luzhou, 646000, Sichuan, 
      China.
FAU - Wang, Yuanyuan
AU  - Wang Y
AD  - Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Taiping Street & NO. 25, Luzhou, 646000, Sichuan, 
      China.
FAU - Liao, Jiangxue
AU  - Liao J
AD  - Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Taiping Street & NO. 25, Luzhou, 646000, Sichuan, 
      China.
FAU - Pan, Hongzhu
AU  - Pan H
AD  - Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Taiping Street & NO. 25, Luzhou, 646000, Sichuan, 
      China.
FAU - Liang, Zhuoping
AU  - Liang Z
AUID- ORCID: 0000-0002-0420-8285
AD  - Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Taiping Street & NO. 25, Luzhou, 646000, Sichuan, 
      China. lzp108@163.com.
LA  - eng
GR  - No. 22154/Doctoral Research Initiation Fund of the Affiliated Hospital of 
      Southwest Medical University/
GR  - No. 2022YFS0629/Sichuan Province Science and Technology Support Program/
PT  - Journal Article
DEP - 20230830
PL  - England
TA  - Allergy Asthma Clin Immunol
JT  - Allergy, asthma, and clinical immunology : official journal of the Canadian 
      Society of Allergy and Clinical Immunology
JID - 101244313
PMC - PMC10470177
OTO - NOTNLM
OT  - Allergens
OT  - Allergic rhinitis
OT  - Interleukin-36
OT  - Symptom assessment
COIS- All authors declare that they have no competing interests.
EDAT- 2023/08/31 00:41
MHDA- 2023/08/31 00:42
PMCR- 2023/08/30
CRDT- 2023/08/30 23:45
PHST- 2023/01/13 00:00 [received]
PHST- 2023/08/14 00:00 [accepted]
PHST- 2023/08/31 00:42 [medline]
PHST- 2023/08/31 00:41 [pubmed]
PHST- 2023/08/30 23:45 [entrez]
PHST- 2023/08/30 00:00 [pmc-release]
AID - 10.1186/s13223-023-00834-y [pii]
AID - 834 [pii]
AID - 10.1186/s13223-023-00834-y [doi]
PST - epublish
SO  - Allergy Asthma Clin Immunol. 2023 Aug 30;19(1):79. doi: 
      10.1186/s13223-023-00834-y.