PMID- 37649345
OWN - NLM
STAT- MEDLINE
DCOM- 20230927
LR  - 20240320
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 57
IP  - 36
DP  - 2023 Sep 12
TI  - Association between a Mixture of Per- and Polyfluoroalkyl Substances (PFAS) and 
      Inflammatory Biomarkers in the Atlanta African American Maternal-Child Cohort.
PG  - 13419-13428
LID - 10.1021/acs.est.3c04688 [doi]
AB  - Per- and polyfluoroalkyl substances (PFAS) have been identified as environmental 
      contributors to adverse birth outcomes. One potential mechanistic pathway could 
      be through PFAS-related inflammation and cytokine production. Here, we examined 
      associations between a PFAS mixture and inflammatory biomarkers during early and 
      late pregnancy from participants enrolled in the Atlanta African American 
      Maternal-Child Cohort (N = 425). Serum concentrations of multiple PFAS were 
      detected in >90% samples at 8-14 weeks gestation. Serum concentrations of 
      interferon-gamma (IFN-gamma), interleukin 6 (IL-6), interleukin 10 (IL-10), tumor 
      necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) were measured at up to 
      two time points (8-14 weeks and 24-30 weeks gestation). The effect of the PFAS 
      mixture on each inflammatory biomarker was examined using quantile g-computation, 
      Bayesian kernel machine regression (BKMR), Bayesian Weighted Sums (BWS), and 
      weighted quantile sum (WQS) regression. Across all models, the PFAS mixture was 
      associated with increased IFN-gamma, IL-10, and TNF-alpha at both time points, with the 
      strongest effects being observed at 24-30 weeks. Using quantile g-computation, 
      increasing concentrations of a PFAS mixture were associated with a 29% (95% 
      confidence interval = 18.0%, 40.7%) increase in TNF-alpha at 24-30 weeks. Similarly, 
      using BWS, the PFAS mixture was associated with increased TNF-alpha at 24-30 weeks 
      (summed effect = 0.29, 95% highest posterior density = 0.17, 0.41). The PFAS 
      mixture was also positively associated with TNF-alpha at 24-30 weeks using BKMR [75th 
      vs 50th percentile: 17.1% (95% credible interval = 7.7%, 27.4%)]. Meanwhile, PFOS 
      was consistently the main drivers of overall mixture effect across four methods. 
      Our findings indicated an increase in prenatal PFAS exposure is associated with 
      an increase in multiple pro-inflammatory cytokines, potentially contributing to 
      adverse pregnancy outcomes.
FAU - Tan, Youran
AU  - Tan Y
AD  - Gangarosa Department of Environmental Health, Rollins School of Public Health, 
      Emory University, 1518 Clifton Rd, Atlanta, Georgia 30329, United States.
FAU - Taibl, Kaitlin R
AU  - Taibl KR
AD  - Gangarosa Department of Environmental Health, Rollins School of Public Health, 
      Emory University, 1518 Clifton Rd, Atlanta, Georgia 30329, United States.
FAU - Dunlop, Anne L
AU  - Dunlop AL
AD  - Department of Gynecology and Obstetrics, School of Medicine, Emory University, 
      Atlanta, Georgia 30329, United States.
FAU - Barr, Dana Boyd
AU  - Barr DB
AD  - Gangarosa Department of Environmental Health, Rollins School of Public Health, 
      Emory University, 1518 Clifton Rd, Atlanta, Georgia 30329, United States.
FAU - Panuwet, Parinya
AU  - Panuwet P
AD  - Gangarosa Department of Environmental Health, Rollins School of Public Health, 
      Emory University, 1518 Clifton Rd, Atlanta, Georgia 30329, United States.
FAU - Yakimavets, Volha
AU  - Yakimavets V
AUID- ORCID: 0000-0002-8864-2408
AD  - Gangarosa Department of Environmental Health, Rollins School of Public Health, 
      Emory University, 1518 Clifton Rd, Atlanta, Georgia 30329, United States.
FAU - Kannan, Kurunthachalam
AU  - Kannan K
AD  - Department of Pediatrics, New York University School of Medicine, New York, New 
      York 10016, United States.
AD  - Department of Environmental Medicine, New York University School of Medicine, New 
      York, 10016, New York United States.
FAU - Corwin, Elizabeth J
AU  - Corwin EJ
AD  - School of Nursing, Columbia University, New York City, New York 10032, United 
      States.
FAU - Ryan, P Barry
AU  - Ryan PB
AD  - Gangarosa Department of Environmental Health, Rollins School of Public Health, 
      Emory University, 1518 Clifton Rd, Atlanta, Georgia 30329, United States.
FAU - Eatman, Jasmin A
AU  - Eatman JA
AD  - Gangarosa Department of Environmental Health, Rollins School of Public Health, 
      Emory University, 1518 Clifton Rd, Atlanta, Georgia 30329, United States.
FAU - Liang, Donghai
AU  - Liang D
AUID- ORCID: 0000-0001-7311-2298
AD  - Gangarosa Department of Environmental Health, Rollins School of Public Health, 
      Emory University, 1518 Clifton Rd, Atlanta, Georgia 30329, United States.
FAU - Eick, Stephanie M
AU  - Eick SM
AUID- ORCID: 0000-0001-6695-3291
AD  - Gangarosa Department of Environmental Health, Rollins School of Public Health, 
      Emory University, 1518 Clifton Rd, Atlanta, Georgia 30329, United States.
LA  - eng
GR  - R01 NR014800/NR/NINR NIH HHS/United States
GR  - U2C ES026542/ES/NIEHS NIH HHS/United States
GR  - P50 ES026071/ES/NIEHS NIH HHS/United States
GR  - U2C OD023375/OD/NIH HHS/United States
GR  - R01 MD009064/MD/NIMHD NIH HHS/United States
GR  - UH3 OD023318/OD/NIH HHS/United States
GR  - R01 MD009746/MD/NIMHD NIH HHS/United States
GR  - R21 ES032117/ES/NIEHS NIH HHS/United States
GR  - U2C ES026560/ES/NIEHS NIH HHS/United States
GR  - P30 ES019776/ES/NIEHS NIH HHS/United States
GR  - R24 ES029490/ES/NIEHS NIH HHS/United States
GR  - UG3 OD023318/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20230830
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Biomarkers)
RN  - 0 (Fluorocarbons)
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Bayes Theorem
MH  - *Biomarkers/blood
MH  - *Black or African American
MH  - *Fluorocarbons/blood
MH  - Interleukin-10
MH  - Tumor Necrosis Factor-alpha
MH  - Pregnancy Outcome
MH  - *Pregnancy Complications/blood/immunology
MH  - *Prenatal Exposure Delayed Effects/blood/immunology
PMC - PMC10900195
MID - NIHMS1966884
OTO - NOTNLM
OT  - Cytokines
OT  - Inflammatory biomarkers
OT  - Per- and polyfluoroalkyl substances (PFAS)
COIS- Conflict of Interest Statement: The authors declare they have nothing to 
      disclose.
EDAT- 2023/08/31 06:41
MHDA- 2023/09/13 06:42
PMCR- 2024/09/12
CRDT- 2023/08/31 02:23
PHST- 2024/09/12 00:00 [pmc-release]
PHST- 2023/09/13 06:42 [medline]
PHST- 2023/08/31 06:41 [pubmed]
PHST- 2023/08/31 02:23 [entrez]
AID - 10.1021/acs.est.3c04688 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2023 Sep 12;57(36):13419-13428. doi: 
      10.1021/acs.est.3c04688. Epub 2023 Aug 30.