PMID- 37649429 OWN - NLM STAT- MEDLINE DCOM- 20241209 LR - 20241209 IS - 1563-5279 (Electronic) IS - 0020-7454 (Linking) VI - 134 IP - 11 DP - 2024 Nov TI - Safety and effectiveness of nusinersen, a treatment for spinal muscular atrophy, in 524 patients: results from an interim analysis of post-marketing surveillance in Japan. PG - 1185-1197 LID - 10.1080/00207454.2023.2251662 [doi] AB - PURPOSE: Nusinersen is an antisense oligonucleotide approved for the treatment of spinal muscular atrophy (SMA). A post-marketing surveillance (PMS) has been ongoing (August 2017-August 2025) in all patients in Japan who were administered nusinersen intrathecally in real-world clinical settings. We report the interim analysis results for safety and effectiveness. METHODS: This interim analysis was conducted using data collected from 524 patients whose case report forms were obtained at least once by May 30, 2022. Collected data included patient demographics and adverse events (AEs) for safety, and motor function assessments and Clinical Global Impressions of Improvement (CGI-I) for effectiveness. RESULTS: Of the 524 patients in the safety analysis set, 522 patients who were diagnosed with SMA were included in the effectiveness analysis (infantile-onset SMA [n = 153, 29.3%], later-onset SMA [n = 369, 70.7%]). The median duration of treatment was 785.0 (range 1-1549) days. AEs occurred in 35.9% of patients (49.0% in infantile-onset SMA and 30.6% in later-onset SMA). Nusinersen treatment significantly improved Hammersmith Infant Neurological Examination scores in patients with infantile-onset SMA and Hammersmith Functional Motor Scale-Expanded scores in patients with later-onset SMA for up to nearly 3 years. Based on CGI-I assessments, 98.5-100% of patients receiving nusinersen 'improved' or remain 'unchanged'. CONCLUSIONS: This interim analysis of the large-scale, all-case PMS in patients who were administered nusinersen in Japan supports the safety and effectiveness of nusinersen. The benefit-risk balance of nusinersen treatment remains favorable. FAU - Tachibana, Yosuke AU - Tachibana Y AUID- ORCID: 0000-0001-5910-2296 AD - Biogen Japan, Tokyo, Japan. FAU - Sato, Ryusuke AU - Sato R AUID- ORCID: 0000-0002-7826-1978 AD - Biogen Japan, Tokyo, Japan. FAU - Makioka, Haruki AU - Makioka H AUID- ORCID: 0000-0002-8295-3723 AD - Biogen Japan, Tokyo, Japan. FAU - Hoshino, Misuzu AU - Hoshino M AUID- ORCID: 0000-0003-1429-9923 AD - Biogen Japan, Tokyo, Japan. FAU - Jin, Mingshou AU - Jin M AUID- ORCID: 0000-0002-6966-5989 AD - Biogen Japan, Tokyo, Japan. LA - eng PT - Journal Article DEP - 20230907 PL - England TA - Int J Neurosci JT - The International journal of neuroscience JID - 0270707 RN - 5Z9SP3X666 (nusinersen) RN - 0 (Oligonucleotides) SB - IM MH - Humans MH - *Oligonucleotides/administration & dosage/pharmacology/adverse effects MH - Japan MH - *Product Surveillance, Postmarketing MH - Male MH - Female MH - Infant MH - *Muscular Atrophy, Spinal/drug therapy MH - Child, Preschool MH - Child MH - Adolescent MH - Adult MH - Young Adult MH - Treatment Outcome MH - Middle Aged MH - Injections, Spinal OTO - NOTNLM OT - Spinal muscular atrophy OT - effectiveness OT - nusinersen OT - post-marketing surveillance OT - safety EDAT- 2023/08/31 06:41 MHDA- 2024/12/09 17:33 CRDT- 2023/08/31 03:48 PHST- 2024/12/09 17:33 [medline] PHST- 2023/08/31 06:41 [pubmed] PHST- 2023/08/31 03:48 [entrez] AID - 10.1080/00207454.2023.2251662 [doi] PST - ppublish SO - Int J Neurosci. 2024 Nov;134(11):1185-1197. doi: 10.1080/00207454.2023.2251662. Epub 2023 Sep 7.