PMID- 37651377
OWN - NLM
STAT- MEDLINE
DCOM- 20230904
LR  - 20230905
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 18
IP  - 8
DP  - 2023
TI  - Autologous micro-fragmented adipose tissue in the treatment of atherosclerosis 
      patients with knee osteoarthritis in geriatric population: A systematic review 
      and meta-analysis.
PG  - e0289610
LID - 10.1371/journal.pone.0289610 [doi]
LID - e0289610
AB  - BACKGROUND: Atherosclerosis and osteoarthritis are closely related. However, no 
      high-quality studies have investigated the potential of micro-fragmented adipose 
      tissue to treat patients with atherosclerosis accompanied by osteoarthritis. 
      METHODS: PubMed, Embase, the Cochrane Library, Web of Science, China National 
      Knowledge Infrastructure, WANFANG DATA, and CQVIP were searched for potentially 
      eligible studies published before October 13, 2022. Due to the statistical 
      limitations of the existing relevant literature, it is not possible to make 
      direct statistics on the patients with osteoarthritis accompanied by 
      atherosclerosis treated by micro-fragmented adipose tissue. The primary outcome 
      consisted of two parts: 1) Correlation between atherosclerosis and 
      osteoarthritis; 2) Scores of the Knee injury and Osteoarthritis Outcome Score 
      (KOOS). And secondary outcomes were pain assessed by visual analog scale (VAS) or 
      numeric rating scale (NRS), quality of life (QoL) (assessed using tools apart 
      from the KOOS), and adverse events (AEs). Random meta-analysis was conducted 
      using STATA 14.0. RESULTS: Nineteen studies were included. The metaanalysis 
      evidenced a positive association between atherosclerosis and osteoarthritis (OR 
      1.17, CI 1.01-1.36). The mean absolute difference in KOOS subscale scores between 
      pre- and post-treatment (mean with 95% confidence interval [CI]) was 19.65 
      (13.66, 25.63), 14.20 (4.64, 23.76), 19.95 (13.02, 26.89), 25.23 (14.80, 35.66), 
      and 26.01 (13.68, 38.35) for pain, symptoms, activities of daily living (ADL), 
      sports/recreation, and quality-of-life (QOL), respectively. The mean differences 
      in VAS, resting VAS, activity VAS, and NRS between pre- and post-treatment was 
      -8.24 (-10.66, -5.82), -3.61 (-4.49, -2.72), -4.17 (-4.89, -3.44), and -2.17 
      (-4.06, and -0.28), respectively. The mean difference in score of Western Ontario 
      and McMaster Universities Osteoarthritis Index (WOMAC), EQ-5D, and University of 
      California in Los Angeles (UCLA) between pre- and post-treatment was -24.81 
      (-40.80, -8.82), 0.07 (0.02, 0.12), and 0.30 (-0.42, 1.02), respectively. The 
      mean difference in Tegner score and the International Knee Documentation 
      Committee (IKDC) score between pre- and post-treatment was 0.67 (-0.62, 1.97) and 
      13.70 (6.35, 21.04), respectively. The use of micro-fragmented adipose tissue was 
      associated with risk of bruising, bleeding, hematoma, drainage, infection, 
      soreness, swelling, pain, and stiffness in harvest and injection sites. 
      CONCLUSION: Atherosclerosis and osteoarthritis share common risk factors and 
      comorbidity. And the use of micro-fragmented adipose tissue may benefit for 
      improving symptoms of knee osteoarthritis accompanied by atherosclerosis although 
      may lead to some mild adverse events. Randomized controlled trials with long-term 
      follow-up are necessary for further evaluation because many limitations of this 
      meta-analysis cannot be ignored.
CI  - Copyright: (c) 2023 Li et al. This is an open access article distributed under the 
      terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Li, Wei
AU  - Li W
AD  - Department of Joint Surgery, Weifang People's Hospital, Weifang, China.
FAU - Guo, Huajuan
AU  - Guo H
AD  - Department of Joint Surgery, Weifang People's Hospital, Weifang, China.
FAU - Wang, Congcong
AU  - Wang C
AUID- ORCID: 0000-0003-3947-2569
AD  - Department of Joint Surgery, Weifang People's Hospital, Weifang, China.
FAU - Zhang, Yimin
AU  - Zhang Y
AD  - Department of Joint Surgery, Weifang People's Hospital, Weifang, China.
FAU - Wang, Jun
AU  - Wang J
AD  - Department of Joint Surgery, Weifang People's Hospital, Weifang, China.
AD  - School of Rehabilitation Medicine, Capital Medical University, Beijing, China.
AD  - China Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20230831
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Humans
MH  - *Osteoarthritis, Knee/complications
MH  - Quality of Life
MH  - Activities of Daily Living
MH  - Adipose Tissue
MH  - *Atherosclerosis/complications
PMC - PMC10470951
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/08/31 18:41
MHDA- 2023/09/04 06:42
PMCR- 2023/08/31
CRDT- 2023/08/31 13:34
PHST- 2023/04/16 00:00 [received]
PHST- 2023/07/22 00:00 [accepted]
PHST- 2023/09/04 06:42 [medline]
PHST- 2023/08/31 18:41 [pubmed]
PHST- 2023/08/31 13:34 [entrez]
PHST- 2023/08/31 00:00 [pmc-release]
AID - PONE-D-23-10633 [pii]
AID - 10.1371/journal.pone.0289610 [doi]
PST - epublish
SO  - PLoS One. 2023 Aug 31;18(8):e0289610. doi: 10.1371/journal.pone.0289610. 
      eCollection 2023.