PMID- 37651803
OWN - NLM
STAT- MEDLINE
DCOM- 20230922
LR  - 20230922
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 166
DP  - 2023 Oct
TI  - Electroacupuncture activates angiogenesis by regulating the PI3K/Pten/Thbs1 
      signaling pathway to promote the browning of adipose tissue in HFD-induced obese 
      mice.
PG  - 115386
LID - S0753-3322(23)01183-6 [pii]
LID - 10.1016/j.biopha.2023.115386 [doi]
AB  - This study investigated the effect of electroacupuncture (EA) on the browning of 
      white adipose tissue (WAT) via angiogenesis and its potential mechanism in obese 
      mice. Four-week-old male C56BL/6 mice were randomly divided into a high-fat diet 
      (HFD) and a normal chow diet (ND) group. After 12 weeks, HFD mice were randomly 
      divided into two groups to receive or not receive EA for 3 weeks. After EA 
      treatment, body weight, adipocyte size, serum glucose (GLU), triacylglycerol 
      (TG), cholesterol (CHO), leptin (Lep), monocyte chemoattractant protein-1 
      (MCP-1), WAT browning-related genes, angiogenesis-related genes, and the 
      PI3K/Pten/Thbs1 signaling pathway were evaluated. The results indicated that EA 
      significantly reduced body weight, adipocyte size, and serum concentrations of 
      GLU, TG, CHO, Lep and MCP-1 and promoted WAT browning. Angiogenesis and the 
      PI3K/Pten/Thbs1 signaling pathway were all activated by EA intervention. The 
      expression levels were consistent with the results of RNA-seq and confirmed via 
      qRTPCR and WB. Our study showed that EA may activate angiogenesis via the 
      PI3K/Pten/Thbs1 signaling pathway in WAT, thereby promoting the browning and 
      thermogenesis of adipose tissue.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Gao, Hongyan
AU  - Gao H
AD  - School of Basic Medical Sciences, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China.
FAU - Li, Yanhui
AU  - Li Y
AD  - Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China.
FAU - Jin, Yue
AU  - Jin Y
AD  - School of Basic Medical Sciences, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - School of Basic Medical Sciences, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China.
FAU - Xia, Xiuwen
AU  - Xia X
AD  - School of Basic Medical Sciences, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China.
FAU - Liu, Jinkun
AU  - Liu J
AD  - Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China.
FAU - Wang, Huaifu
AU  - Wang H
AD  - School of Basic Medical Sciences, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China.
FAU - Xie, Ya
AU  - Xie Y
AD  - Sichuan Provincial People's Hospital Jinniu Hospital, Chengdu 610007, China.
FAU - Ding, Weijun
AU  - Ding W
AD  - School of Basic Medical Sciences, Chengdu University of Traditional Chinese 
      Medicine, Chengdu 611137, China. Electronic address: dingweijun@cdutcm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230829
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - 0 (Thrombospondin 1)
SB  - IM
MH  - Animals
MH  - Male
MH  - Mice
MH  - Adipose Tissue
MH  - Body Weight
MH  - Diet, High-Fat/adverse effects
MH  - *Electroacupuncture
MH  - Mice, Obese
MH  - Phosphatidylinositol 3-Kinases
MH  - PTEN Phosphohydrolase/metabolism
MH  - Thrombospondin 1/metabolism
MH  - *Signal Transduction
OTO - NOTNLM
OT  - Angiogenesis
OT  - Browning
OT  - Electroacupuncture (EA)
OT  - Obesity
OT  - White adipose tissue (WAT)
COIS- Declaration of Competing Interest The authors declare that they have no conflicts 
      of interest.
EDAT- 2023/09/01 00:41
MHDA- 2023/09/18 12:44
CRDT- 2023/08/31 18:03
PHST- 2023/06/25 00:00 [received]
PHST- 2023/08/23 00:00 [revised]
PHST- 2023/08/23 00:00 [accepted]
PHST- 2023/09/18 12:44 [medline]
PHST- 2023/09/01 00:41 [pubmed]
PHST- 2023/08/31 18:03 [entrez]
AID - S0753-3322(23)01183-6 [pii]
AID - 10.1016/j.biopha.2023.115386 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2023 Oct;166:115386. doi: 10.1016/j.biopha.2023.115386. Epub 
      2023 Aug 29.