PMID- 37652221 OWN - NLM STAT- Publisher LR - 20231022 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 237 IP - Pt 2 DP - 2023 Nov 15 TI - Prepandemic personal concentrations of per- and polyfluoroalkyl substances (PFAS) and other pollutants: Specific and combined effects on the incidence of COVID-19 disease and SARS-CoV-2 infection. PG - 116965 LID - S0013-9351(23)01769-3 [pii] LID - 10.1016/j.envres.2023.116965 [doi] AB - OBJECTIVE: To investigate the specific and combined effects of personal concentrations of some per- and polyfluoroalkyl substances (PFAS), other persistent organic pollutants (POPs), and chemical elements -measured in individuals' blood several years before the pandemic- on the development of SARS-CoV-2 infection and COVID-19 disease in the general population. METHODS: We conducted a prospective cohort study in 240 individuals from the general population of Barcelona. PFAS, other POPs, and chemical elements were measured in plasma, serum, and whole blood samples, respectively, collected in 2016-2017. PFAS were analyzed by liquid chromatography-triple quadrupole mass spectrometry. SARS-CoV-2 infection was detected by rRT-PCR in nasopharyngeal swabs and/or antibody serology in blood samples collected in 2020-2021. RESULTS: No individual PFAS nor their mixtures were significantly associated with SARS-CoV-2 seropositivity or COVID-19 disease. Previously identified mixtures of POPs and elements (Porta et al., 2023) remained significantly associated with seropositivity and COVID-19 when adjusted for PFAS (all OR > 4 or p < 0.05). Nine chemicals comprised mixtures associated with COVID-19: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, other DDT-related compounds, manganese, tantalum, and aluminium. And nine chemicals comprised the mixtures more consistently associated with SARS-CoV-2 seropositivity: thallium, ruthenium, lead, benzo[b]fluoranthene, DDD, gold, and (protectively) selenium, indium, and iron. CONCLUSIONS: The PFAS studied were not associated with SARS-CoV-2 seropositivity or COVID-19. The results confirm the associations between personal blood concentrations of some POPs and chemical elements and the risk of COVID-19 and SARS-CoV-2 infection in what remains the only prospective and population-based cohort study on the topic. Mixtures of POPs and chemical elements may contribute to explain the heterogeneity in the risks of SARS-CoV-2 infection and COVID-19 in the general population. CI - Copyright (c) 2023 Elsevier Inc. All rights reserved. FAU - Pumarega, Jose AU - Pumarega J AD - School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain; Hospital del Mar Research Institute, Barcelona, Spain; CIBER de Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain. Electronic address: jpumarega@imim.es. FAU - Gasull, Magda AU - Gasull M AD - Hospital del Mar Research Institute, Barcelona, Spain; CIBER de Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Catalonia, Spain. FAU - Koponen, Jani AU - Koponen J AD - Finnish Institute for Health and Welfare (THL), Kuopio, Finland. FAU - Campi, Laura AU - Campi L AD - Hospital del Mar Research Institute, Barcelona, Spain. FAU - Rantakokko, Panu AU - Rantakokko P AD - Finnish Institute for Health and Welfare (THL), Kuopio, Finland. FAU - Henriquez-Hernandez, Luis A AU - Henriquez-Hernandez LA AD - Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain; CIBER de Obesidad y Nutricion (CIBEROBN), Madrid, Spain. FAU - Aguilar, Ruth AU - Aguilar R AD - ISGlobal, Hospital Clinic - Universitat de Barcelona, Barcelona, Spain. FAU - Donat-Vargas, Carolina AU - Donat-Vargas C AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain; ISGlobal, Campus Mar, Barcelona, Spain; Cardiovascular and Nutritonal Epidemiology Unit, Institut of Enviornmental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Zumbado, Manuel AU - Zumbado M AD - Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain; CIBER de Obesidad y Nutricion (CIBEROBN), Madrid, Spain. FAU - Villar-Garcia, Judit AU - Villar-Garcia J AD - Hospital del Mar Research Institute, Barcelona, Spain. FAU - Rius, Cristina AU - Rius C AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Catalonia, Spain; Agencia de Salut Publica de Barcelona, Barcelona, Spain. FAU - Santiago-Diaz, Pablo AU - Santiago-Diaz P AD - Hospital del Mar Research Institute, Barcelona, Spain. FAU - Vidal, Marta AU - Vidal M AD - ISGlobal, Hospital Clinic - Universitat de Barcelona, Barcelona, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain. FAU - Jimenez, Alfons AU - Jimenez A AD - ISGlobal, Hospital Clinic - Universitat de Barcelona, Barcelona, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain. FAU - Iglesias, Mar AU - Iglesias M AD - Hospital del Mar Research Institute, Barcelona, Spain. FAU - Dobano, Carlota AU - Dobano C AD - ISGlobal, Hospital Clinic - Universitat de Barcelona, Barcelona, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain. FAU - Moncunill, Gemma AU - Moncunill G AD - ISGlobal, Hospital Clinic - Universitat de Barcelona, Barcelona, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain. FAU - Porta, Miquel AU - Porta M AD - School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain; Hospital del Mar Research Institute, Barcelona, Spain; CIBER de Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Catalonia, Spain. Electronic address: mporta@imim.es. LA - eng PT - Journal Article DEP - 20230829 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 SB - IM OTO - NOTNLM OT - COVID-19 OT - Immunotoxicity OT - Mixtures OT - Per- and polyfluoroalkyl substances (PFAS) OT - SARS-CoV-2 COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/09/01 00:41 MHDA- 2023/09/01 00:41 CRDT- 2023/08/31 19:26 PHST- 2023/07/21 00:00 [received] PHST- 2023/08/17 00:00 [revised] PHST- 2023/08/22 00:00 [accepted] PHST- 2023/09/01 00:41 [pubmed] PHST- 2023/09/01 00:41 [medline] PHST- 2023/08/31 19:26 [entrez] AID - S0013-9351(23)01769-3 [pii] AID - 10.1016/j.envres.2023.116965 [doi] PST - ppublish SO - Environ Res. 2023 Nov 15;237(Pt 2):116965. doi: 10.1016/j.envres.2023.116965. Epub 2023 Aug 29.