PMID- 37653222
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 61
IP  - 2
DP  - 2024 Feb
TI  - Asiaticoside Attenuates Blood-Spinal Cord Barrier Disruption by Inhibiting 
      Endoplasmic Reticulum Stress in Pericytes After Spinal Cord Injury.
PG  - 678-692
LID - 10.1007/s12035-023-03605-3 [doi]
AB  - The blood-spinal cord barrier (BSCB) plays a vital role in the recovery of spinal 
      cord function after spinal cord injury (SCI). Pericytes, pluripotent members of 
      the neurovascular unit (NVU), receive signals from neighboring cells and are 
      critical for maintaining CNS function. Therapeutic targets for the BSCB include 
      endothelial cells (ECs) and glial cells, but few drugs target pericytes. This 
      study was designed to explore whether asiaticoside has a positively effect on 
      pericytes and the integrity of the BSCB. In this study, we found that 
      asiaticoside could inhibit the loss of junction proteins just 1 day after SCI in 
      vivo, but our in vitro study showed no significant differences in the expression 
      of endothelial junction proteins between the control and asiaticoside treatment 
      groups. We also found that asiaticoside could inhibit endoplasmic reticulum (ER) 
      stress and pericyte apoptosis, which might be associated with the inhibition of 
      junction protein reduction in ECs. Thus, we investigated the interactions between 
      pericytes and ECs. Our results showed that asiaticoside could decrease the 
      release of matrix metalloproteinase (MMP)-9 in pericytes and therefore upregulate 
      the expression of junction proteins in ECs. Furthermore, the protective effect of 
      asiaticoside on pericytes is related to the inhibition of ER stress via the MAPK 
      signaling pathway. Taken together, our results demonstrate that asiaticoside 
      treatment inhibits BSCB disruption and enhances functional recovery after SCI.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Hu, Zhenxin
AU  - Hu Z
AD  - Department of Orthopedics, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, 116011, China.
FAU - Wu, Tingting
AU  - Wu T
AD  - The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, 
      China.
FAU - Zhou, Ziheng
AU  - Zhou Z
AD  - The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, 
      China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315302, 
      China.
FAU - Chen, Qiyue
AU  - Chen Q
AD  - The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, 
      China.
FAU - Yao, Hanbing
AU  - Yao H
AD  - The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, 
      China.
FAU - Ji, Mengchu
AU  - Ji M
AD  - The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, 
      China.
FAU - Shen, Ge
AU  - Shen G
AD  - The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, 
      China.
FAU - Dong, Chenling
AU  - Dong C
AD  - The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, 
      China.
FAU - Shi, Chengge
AU  - Shi C
AD  - The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, 
      China.
FAU - Huang, Zhixian
AU  - Huang Z
AD  - The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, 
      China.
FAU - Jiang, Nizhou
AU  - Jiang N
AD  - Department of Orthopedics, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, 116011, China.
FAU - Han, Nan
AU  - Han N
AD  - Department of Ultrasonography, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, 116011, China. 14134442@qq.com.
FAU - Tian, Xiliang
AU  - Tian X
AUID- ORCID: 0000-0001-9703-2743
AD  - Department of Orthopedics, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, 116011, China. tianxiliang1983@163.com.
LA  - eng
GR  - 81403229/Innovative Research Group Project of the National Natural Science 
      Foundation of China/
PT  - Journal Article
DEP - 20230901
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - PKO39VY215 (asiaticoside)
RN  - 0 (Triterpenes)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Humans
MH  - *Pericytes/metabolism
MH  - Endothelial Cells/metabolism
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/metabolism
MH  - *Spinal Cord Injuries/metabolism
MH  - Blood-Brain Barrier/metabolism
MH  - Endoplasmic Reticulum Stress
MH  - *Triterpenes
OTO - NOTNLM
OT  - Asiaticoside
OT  - Blood-spinal cord barrier
OT  - Endoplasmic reticulum stress
OT  - Pericytes
OT  - Spinal cord injury
EDAT- 2023/09/01 00:41
MHDA- 2024/02/12 15:44
CRDT- 2023/08/31 23:37
PHST- 2022/11/25 00:00 [received]
PHST- 2023/08/16 00:00 [accepted]
PHST- 2024/02/12 15:44 [medline]
PHST- 2023/09/01 00:41 [pubmed]
PHST- 2023/08/31 23:37 [entrez]
AID - 10.1007/s12035-023-03605-3 [pii]
AID - 10.1007/s12035-023-03605-3 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2024 Feb;61(2):678-692. doi: 10.1007/s12035-023-03605-3. Epub 2023 
      Sep 1.