PMID- 37654524
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230902
IS  - 1726-9148 (Electronic)
IS  - 1726-913X (Print)
IS  - 1726-913X (Linking)
VI  - 21
IP  - 2
DP  - 2023 Apr
TI  - Effect of a Reduced-Calorie Diet on Plasma Levels of Inflammatory and Metabolic 
      Factors in Overweight/Obese Patients with Cardiovascular Risk Factors.
PG  - e135216
LID - 10.5812/ijem-135216 [doi]
LID - e135216
AB  - BACKGROUND: Calorie restriction without malnutrition is likely to improve 
      cardiovascular risk factors. OBJECTIVES: The aim of this study was to investigate 
      calorie restriction on markers of cardiometabolic risk in overweight/obese adults 
      with cardiovascular risk factors. METHODS: In a parallel controlled trial, 
      patients with overweight or obesity and one or more cardiovascular risk factor 
      were randomized to a modest reduced-calorie diet (75% of the total calculated 
      energy requirements) or control (no calorie restriction) groups and followed up 
      for two months. Body weight, dietary intake, fasting plasma levels of C-reactive 
      protein (CRP), monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion 
      molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), brain-derived 
      neurotrophic factor (BDNF), neuropeptide Y (NPY), lipids, and glycemic factors 
      were measured at baseline, and after two months. The differences were analyzed 
      with analysis of covariance (ANCOVA). RESULTS: Sixty-six participants (33 in each 
      group) completed the study. Body weight changed in the reduced-calorie diet group 
      (- 3.05 +/- 2.65 kg), and blood pressure was improved (systolic -6.96 +/- 12.04 and 
      diastolic - 3.90 +/- 8.97 mmHg). The reduced-calorie diet improved plasma ICAM-1 
      (change from baseline - 0.45 +/- 1.99 ng/mL, P = 0.033, ANCOVA), MCP-1 (change from 
      baseline - 0.50 pg/mL, P = 0.011, ANCOVA), low-density lipoprotein cholesterol 
      (change from baseline - 9.35 +/- 19.61 mg/dL, P < 0.001, ANCOVA), and triglyceride 
      (change from baseline -33.66 +/- 49.08, P = 0.001, ANCOVA), but BDNF, NPY, and 
      other cardiometabolic factors were not different. CONCLUSIONS: In 
      overweight/obese subjects with cardiovascular risk factors which have been under 
      medical treatment with risk-reducing medications, a modest weight loss induced by 
      a reduced-calorie diet improved lipid profile, blood pressure, and reduced ICAM-1 
      and MCP-1 levels but had no effect on plasma BDNF or glycemic factors.
CI  - Copyright (c) 2023, International Journal of Endocrinology and Metabolism.
FAU - Nasrollahzadeh, Javad
AU  - Nasrollahzadeh J
AD  - Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Sciences and 
      Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Khandouzi, Nafiseh
AU  - Khandouzi N
AD  - Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Sciences and 
      Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Maroofi, Mahsa
AU  - Maroofi M
AD  - Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Sciences and 
      Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230516
PL  - Netherlands
TA  - Int J Endocrinol Metab
JT  - International journal of endocrinology and metabolism
JID - 101235597
PMC - PMC10467581
OTO - NOTNLM
OT  - Calorie-Restriction
OT  - Cardiometabolic
OT  - Obesity
COIS- Conflict of Interests: All authors declare that they have no conflict of 
      interests.
EDAT- 2023/09/01 06:43
MHDA- 2023/09/01 06:44
PMCR- 2023/04/01
CRDT- 2023/09/01 03:57
PHST- 2023/01/25 00:00 [received]
PHST- 2023/04/16 00:00 [revised]
PHST- 2023/05/01 00:00 [accepted]
PHST- 2023/09/01 06:44 [medline]
PHST- 2023/09/01 06:43 [pubmed]
PHST- 2023/09/01 03:57 [entrez]
PHST- 2023/04/01 00:00 [pmc-release]
AID - 10.5812/ijem-135216 [doi]
PST - epublish
SO  - Int J Endocrinol Metab. 2023 May 16;21(2):e135216. doi: 10.5812/ijem-135216. 
      eCollection 2023 Apr.