PMID- 37655052
OWN - NLM
STAT- Publisher
LR  - 20230902
IS  - 2688-2663 (Electronic)
IS  - 2688-2663 (Linking)
VI  - 4
IP  - 5
DP  - 2023 Oct
TI  - Chaperone-mediated autophagy: Molecular mechanisms, biological functions, and 
      diseases.
PG  - e347
LID - 10.1002/mco2.347 [doi]
LID - e347
AB  - Chaperone-mediated autophagy (CMA) is a lysosomal degradation pathway that 
      eliminates substrate proteins through heat-shock cognate protein 70 recognition 
      and lysosome-associated membrane protein type 2A-assisted translocation. It is 
      distinct from macroautophagy and microautophagy. In recent years, the regulatory 
      mechanisms of CMA have been gradually enriched, including the newly discovered 
      NRF2 and p38-TFEB signaling, as positive and negative regulatory pathways of CMA, 
      respectively. Normal CMA activity is involved in the regulation of metabolism, 
      aging, immunity, cell cycle, and other physiological processes, while CMA 
      dysfunction may be involved in the occurrence of neurodegenerative disorders, 
      tumors, intestinal disorders, atherosclerosis, and so on, which provides 
      potential targets for the treatment and prediction of related diseases. This 
      article describes the general process of CMA and its role in physiological 
      activities and summarizes the connection between CMA and macroautophagy. In 
      addition, human diseases that concern the dysfunction or protective role of CMA 
      are discussed. Our review deepens the understanding of the mechanisms and 
      physiological functions of CMA and provides a summary of past CMA research and a 
      vision of future directions.
CI  - (c) 2023 The Authors. MedComm published by Sichuan International Medical Exchange & 
      Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
FAU - Yao, Ruchen
AU  - Yao R
AD  - Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology 
      and Hepatology Ministry of Health, Inflammatory Bowel Disease Research Center 
      Shanghai China.
AD  - Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China.
AD  - Shanghai Institute of Digestive Disease Shanghai China.
FAU - Shen, Jun
AU  - Shen J
AD  - Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology 
      and Hepatology Ministry of Health, Inflammatory Bowel Disease Research Center 
      Shanghai China.
AD  - Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China.
AD  - Shanghai Institute of Digestive Disease Shanghai China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230830
PL  - China
TA  - MedComm (2020)
JT  - MedComm
JID - 101769925
PMC - PMC10466100
OTO - NOTNLM
OT  - carcinoma
OT  - chaperone-mediated autophagy
OT  - neurodegenerative disorders
OT  - signaling regulation
OT  - therapeutic potential
COIS- The authors declare that they have no conflict of interest.
EDAT- 2023/09/01 06:43
MHDA- 2023/09/01 06:43
PMCR- 2023/08/30
CRDT- 2023/09/01 04:05
PHST- 2022/12/15 00:00 [received]
PHST- 2023/07/23 00:00 [revised]
PHST- 2023/07/27 00:00 [accepted]
PHST- 2023/09/01 06:43 [medline]
PHST- 2023/09/01 06:43 [pubmed]
PHST- 2023/09/01 04:05 [entrez]
PHST- 2023/08/30 00:00 [pmc-release]
AID - MCO2347 [pii]
AID - 10.1002/mco2.347 [doi]
PST - epublish
SO  - MedComm (2020). 2023 Aug 30;4(5):e347. doi: 10.1002/mco2.347. eCollection 2023 
      Oct.