PMID- 37655471
OWN - NLM
STAT- MEDLINE
DCOM- 20230920
LR  - 20230920
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 14
IP  - 18
DP  - 2023 Sep 19
TI  - Fagopyrum tataricum ethanol extract ameliorates symptoms of hyperglycemia by 
      regulating gut microbiota in type 2 diabetes mellitus mice.
PG  - 8487-8503
LID - 10.1039/d3fo02385k [doi]
AB  - Type 2 diabetes mellitus (T2DM) is typically accompanied by sudden weight loss, 
      dyslipidemia-related indicators, decreased insulin sensitivity, and altered gut 
      microbial communities. Fagopyrum tataricum possesses many biological activities, 
      such as antioxidant, hypolipidemic, and hypotensive activities. However, only a 
      few studies have attempted to elucidate the regulatory effects of F. tataricum 
      ethanol extract (FTE) on intestinal microbial communities and its potential 
      relationships with T2DM. In this study, we established a T2DM mouse model and 
      investigated the regulatory effects of FTE on hyperglycemia symptoms and 
      intestinal microbial communities. FTE intervention significantly improved the 
      levels of fasting blood glucose, the area under the curve of oral glucose 
      tolerance test (OGTT), and glycosylated serum protein, as well as pancreas islet 
      function correlation index. In addition, FTE effectively improved hepatic and 
      cecum injuries and insulin secretion due to T2DM. It was also revealed that the 
      potential hypoglycemic mechanism of FTE was involved in the regulation of protein 
      kinase B (AKT-1) and glucose transporter 2 (GLUT-2). Furthermore, compared with 
      the Model group, the FTE-H intervention exhibited a significantly decreased ratio 
      of Firmicutes to Bacteroidetes at the phylum level, reduced relative abundance of 
      pernicious bacteria at the genus level, such as Desulfovibrio, Oscillibacter, 
      Blautia, Parabacteroides, and Erysipelatoclostridium, and ameliorated 
      inflammatory response and insulin resistance. Moreover, the correlation between 
      gut microbiota and hypoglycemic indicators was predicted. The results showed that 
      Lachnoclostridium, Lactobacillus, Oscillibacter, Bilophila, and Roseburia have 
      the potential to be used as bacterial markers for T2DM. In conclusion, our 
      research showed that FTE alleviates hyperglycemia symptoms by regulating the 
      expression of AKT-1 and GLUT-2, as well as intestinal microbial communities in 
      T2DM mice.
FAU - Ge, Xiaodong
AU  - Ge X
AUID- ORCID: 0000-0002-3300-6711
AD  - College of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, 
      Jiangsu 224051, China. xuweiyc@163.com.
FAU - Liu, Tingting
AU  - Liu T
AD  - Clinical Pharmacy Department, Yancheng Second People's Hospital, Yancheng, 
      Jiangsu 224051, China.
FAU - Chen, Zhuo
AU  - Chen Z
AD  - School of Chemistry & Chemical Engineering, Yancheng Institute of Technology, 
      Yancheng, Jiangsu 224051, China.
FAU - Zhang, Jiawei
AU  - Zhang J
AD  - School of Chemistry & Chemical Engineering, Yancheng Institute of Technology, 
      Yancheng, Jiangsu 224051, China.
FAU - Yin, Xuemei
AU  - Yin X
AD  - College of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, 
      Jiangsu 224051, China. xuweiyc@163.com.
FAU - Huang, Zirui
AU  - Huang Z
AUID- ORCID: 0000-0002-0822-352X
AD  - School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 
      200240, China.
FAU - Chen, Ligen
AU  - Chen L
AUID- ORCID: 0000-0002-1460-3457
AD  - College of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, 
      Jiangsu 224051, China. xuweiyc@163.com.
FAU - Zhao, Chao
AU  - Zhao C
AUID- ORCID: 0000-0003-1096-632X
AD  - College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Shao, Rong
AU  - Shao R
AD  - College of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, 
      Jiangsu 224051, China. xuweiyc@163.com.
FAU - Xu, Wei
AU  - Xu W
AUID- ORCID: 0000-0002-0551-1251
AD  - College of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, 
      Jiangsu 224051, China. xuweiyc@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230919
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - 0 (Hypoglycemic Agents)
RN  - 3K9958V90M (Ethanol)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Gastrointestinal Microbiome
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - *Fagopyrum
MH  - Proto-Oncogene Proteins c-akt
MH  - *Hyperglycemia/drug therapy
MH  - Hypoglycemic Agents
MH  - Firmicutes
MH  - *Lactobacillales
MH  - Bacteroidetes
MH  - Clostridiales
MH  - Ethanol
MH  - Plant Extracts
EDAT- 2023/09/01 06:43
MHDA- 2023/09/20 06:42
CRDT- 2023/09/01 05:25
PHST- 2023/09/20 06:42 [medline]
PHST- 2023/09/01 06:43 [pubmed]
PHST- 2023/09/01 05:25 [entrez]
AID - 10.1039/d3fo02385k [doi]
PST - epublish
SO  - Food Funct. 2023 Sep 19;14(18):8487-8503. doi: 10.1039/d3fo02385k.