PMID- 3765552
OWN - NLM
STAT- MEDLINE
DCOM- 19861114
LR  - 20190819
IS  - 0042-9007 (Print)
IS  - 0042-9007 (Linking)
VI  - 51 Suppl 2
DP  - 1986
TI  - Therapy in cytopenia.
PG  - 69-73
AB  - Intravenous immunoglobulin (IVIG) may be considered first-line maintenance 
      therapy for idiopathic thrombocytopenic purpura (ITP) because it has been proven 
      to be the least toxic. In a study of 25 children with acute ITP, treatment with 
      IVIG maintained platelet counts above 40,000/mm3 in all of the children. After 1 
      year, none of these patients required further therapy. In another study group of 
      25 pediatric patients with chronic ITP, treatment with IVIG circumvented 
      splenectomy in 60% of the cases. The therapeutic regimens for adults and children 
      are described, as is a strategy to overcome IVIG resistance. Experience with IVIG 
      in hemolytic anemia and neutropenia are discussed. The mechanism of action is 
      explored in some detail, specifically as it relates to reticuloendothelial system 
      (RES) Fc receptor blockade and suppression of antiplatelet antibody synthesis.
FAU - Bussell, J
AU  - Bussell J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
RN  - 0 (Antibodies)
RN  - 0 (Immunoglobulin G)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Adult
MH  - Anemia, Hemolytic/drug therapy
MH  - Antibodies/immunology
MH  - Autoimmune Diseases/drug therapy
MH  - Blood Platelets/drug effects/immunology
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - *Immunization, Passive
MH  - Immunoglobulin G/administration & dosage
MH  - Infusions, Intravenous
MH  - Neutropenia/drug therapy
MH  - Platelet Count
MH  - Prednisone/pharmacology
MH  - Purpura, Thrombocytopenic/*drug therapy/therapy
MH  - Splenectomy
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1111/j.1423-0410.1986.tb02011.x [doi]
PST - ppublish
SO  - Vox Sang. 1986;51 Suppl 2:69-73. doi: 10.1111/j.1423-0410.1986.tb02011.x.