PMID- 37655696
OWN - NLM
STAT- MEDLINE
DCOM- 20230920
LR  - 20230920
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 14
IP  - 18
DP  - 2023 Sep 19
TI  - Lactobacillus gasseri CKCC1913 mediated modulation of the gut-liver axis 
      alleviated insulin resistance and liver damage induced by type 2 diabetes.
PG  - 8504-8520
LID - 10.1039/d3fo01701j [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by 
      dysregulation of lipid metabolism, insulin resistance, and gut microbiota 
      disorder. Compared to drug interventions, probiotic interventions may have a more 
      enduring effect without producing any side effects. Thus, the potential of 
      probiotics as a therapeutic approach for diabetes and other metabolic disorders 
      has gained increasing attention in recent years. In this study, we evaluated the 
      therapeutic efficacy of Lactobacillus gasseri CKCC1913, a potential probiotic 
      strain, in high-fat diet-induced insulin-resistant diabetes using the C57BL/6J 
      mouse animal model. From the results, L. gasseri CKCC1913 has been shown to 
      increase glucose tolerance, reduce fasting blood glucose levels in diabetic mice, 
      and reduce the expression of pro-inflammatory cytokines, such as TNF-alpha and IL-6. 
      Besides, L. gasseri CKCC1913 intervention effectively alleviated oxidative stress 
      damage by increasing SOD activity, decreasing MDA levels, reducing insulin 
      resistance, and improving dyslipidemia caused by diabetes. The potential 
      mechanism of L. gasseri CKCC1913 in improving metabolic health and alleviating 
      diabetes involves an increased abundance of beneficial bacteria, such as 
      Parabacteroides merdae, which directly produce short-chain fatty acids that help 
      regulate immune cells and reduce inflammation. SCFAs also enter the bloodstream 
      and promote antioxidant enzyme activity in the liver, protecting against 
      oxidative damage. Additionally, L. gasseri CKCC1913 influences local bacterial 
      metabolism pathways, such as the superpathway of unsaturated fatty acid 
      biosynthesis, leading to an increase in unsaturated fatty acids, increasing 
      high-density lipoprotein cholesterol (HDL-C) levels and improving lipid 
      metabolism and glucose control in diabetic mice. In summary, in this study, L. 
      gasseri CKCC1913 and its potential impact on metabolic health highlight the 
      promising potential of probiotics as a therapeutic approach for diabetes. Future 
      research should focus on identifying the optimal dose and duration, investigating 
      the long-term effects and mechanisms of action, and exploring the potential use 
      of probiotics as an adjunct to other therapies or in preventing metabolic 
      disorders.
FAU - Jiang, Shuaiming
AU  - Jiang S
AUID- ORCID: 0000-0002-9384-9200
AD  - Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School 
      of Food Science and Engineering, Hainan University, Haikou 570228, China. 
      zhjch321123@163.com.
FAU - Liu, Aijie
AU  - Liu A
AD  - ClassyKiss Dairy (Shenzhen) Co., Ltd, China.
FAU - Ma, Wenyao
AU  - Ma W
AD  - Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School 
      of Food Science and Engineering, Hainan University, Haikou 570228, China. 
      zhjch321123@163.com.
FAU - Liu, Xinlei
AU  - Liu X
AD  - Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School 
      of Food Science and Engineering, Hainan University, Haikou 570228, China. 
      zhjch321123@163.com.
FAU - Luo, Pengfei
AU  - Luo P
AD  - ClassyKiss Dairy (Shenzhen) Co., Ltd, China.
FAU - Zhan, Meng
AU  - Zhan M
AD  - ClassyKiss Dairy (Shenzhen) Co., Ltd, China.
FAU - Zhou, Xiaoli
AU  - Zhou X
AD  - ClassyKiss Dairy (Shenzhen) Co., Ltd, China.
FAU - Chen, Lihao
AU  - Chen L
AD  - ClassyKiss Dairy (Shenzhen) Co., Ltd, China.
FAU - Zhang, Jiachao
AU  - Zhang J
AUID- ORCID: 0000-0001-8099-6749
AD  - Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School 
      of Food Science and Engineering, Hainan University, Haikou 570228, China. 
      zhjch321123@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230919
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Antioxidants)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - *Lactobacillus gasseri
MH  - *Insulin Resistance
MH  - *Diabetes Mellitus, Experimental/therapy
MH  - Liver
MH  - Antioxidants
EDAT- 2023/09/01 12:43
MHDA- 2023/09/20 06:42
CRDT- 2023/09/01 07:02
PHST- 2023/09/20 06:42 [medline]
PHST- 2023/09/01 12:43 [pubmed]
PHST- 2023/09/01 07:02 [entrez]
AID - 10.1039/d3fo01701j [doi]
PST - epublish
SO  - Food Funct. 2023 Sep 19;14(18):8504-8520. doi: 10.1039/d3fo01701j.