PMID- 37658097
OWN - NLM
STAT- MEDLINE
DCOM- 20230904
LR  - 20231121
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Sep 1
TI  - Retinal vascular and structural recovery analysis by optical coherence tomography 
      angiography after endoscopic decompression in sellar/parasellar tumors.
PG  - 14371
LID - 10.1038/s41598-023-40956-2 [doi]
LID - 14371
AB  - We assessed the potential retinal microcirculation alterations for postoperative 
      visual recovery in sellar/paraseller tumor patients with Optical Coherence 
      Tomography Angiography (OCT-A). Two hundred ten eyes with sellar/parasellar tumor 
      for which preoperative and postoperative (3 months) MRI Scans, Visual Acuity 
      Test, Optical Coherence Tomography (OCT), OCT-A and, Visual Field Test data were 
      available, besides 92 healthy eyes were evaluated. In the preoperative phase, 
      significant reductions were observed in retinal vascular densities in various 
      regions, including the Superficial Retinal Capillary Plexus (SRCP) (whole: 
      p < 0.001, fovea: p = 0.025, parafovea: p < 0.001), Deep Retinal Capillary Plexus 
      (DRCP) (whole: p < 0.001, fovea: p = 0.003, parafovea: p < 0.001), Peripapillary 
      Vascular Density (PVD) (whole: p = 0.045, peripapillary: p < 0.001, nasal: 
      p < 0.001, inferior: p < 0.001, temporal: p < 0.001), and Retinal Nerve Fiber 
      Layer (RNFL) (nasal: p = 0.024, inferior: p < 0.001, temporal: p < 0.001, 
      superior: p < 0.001) compared to the healthy control group. After surgery, the 
      postoperative data of patients without chiasmal distortion were compared to their 
      preoperative data. In the postoperative evaluation, significant increases were 
      observed in vascular densities in patients without chiasmal distortion in the 
      SRCP (whole: p < 0.001, parafovea: p = 0.045), DRCP (whole: p = 0.007, fovea: 
      p = 0.006, parafovea: p = 0.040), PVD (peripapillary: p = 0.010, inferior: 
      p < 0.001, temporal: p < 0.001, superior: p < 0.001), and RNFL (nasal: p = 0.011, 
      inferior: p = 0.034, temporal: p = 0.046, superior: p = 0.011). Furthermore, 
      significant associations were observed in the ROC analysis between the 
      postoperative Visual Field Mean Deviation (VFMD) and SRCP (whole AUC = 0.793, 
      p < 0.001, cut-off = 51.45, parafovea AUC = 0.820, p < 0.001, cut-off = 53.95), 
      DRCP (whole AUC = 0.818, p < 0.001, cut-off = 55.95, parafovea AUC = 0.820, 
      p < 0.001, cut-off = 59.05), PVD (temporal AUC = 0.692, p < 0.001, 
      cut-off = 55.10), and RNFL (whole AUC = 0.690, p = 0.001, cut-off = 119.5, 
      inferior AUC = 0.712, p < 0.001, cut-off = 144.75). These findings indicate a 
      potential role of pre and post-operative OCT-A measurements in the assessment of 
      surgical timing and postoperative visual recovery in patients with or without 
      optic chiasm distortion.
CI  - (c) 2023. Springer Nature Limited.
FAU - Ergen, Anil
AU  - Ergen A
AD  - Department of Neurosurgery and Pituitary Research Center, School of Medicine, 
      Kocaeli University, 41380, Kocaeli, Turkey.
FAU - Kaya Ergen, Sebnem
AU  - Kaya Ergen S
AD  - Department of Ophthalmology, Kocaeli Seka State Hospital, Kocaeli, Turkey.
FAU - Gunduz, Busra
AU  - Gunduz B
AD  - Department of Neurosurgery and Pituitary Research Center, School of Medicine, 
      Kocaeli University, 41380, Kocaeli, Turkey.
FAU - Subasi, Sevgi
AU  - Subasi S
AD  - Department of Ophthalmology, School of Medicine, Kocaeli University, Kocaeli, 
      Turkey.
FAU - Caklili, Melih
AU  - Caklili M
AD  - Department of Neurosurgery and Pituitary Research Center, School of Medicine, 
      Kocaeli University, 41380, Kocaeli, Turkey.
FAU - Cabuk, Burak
AU  - Cabuk B
AD  - Department of Neurosurgery and Pituitary Research Center, School of Medicine, 
      Kocaeli University, 41380, Kocaeli, Turkey.
FAU - Anik, Ihsan
AU  - Anik I
AD  - Department of Neurosurgery and Pituitary Research Center, School of Medicine, 
      Kocaeli University, 41380, Kocaeli, Turkey.
FAU - Ceylan, Savas
AU  - Ceylan S
AD  - Department of Neurosurgery and Pituitary Research Center, School of Medicine, 
      Kocaeli University, 41380, Kocaeli, Turkey. ssceylan@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20230901
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - *Tomography, Optical Coherence
MH  - Decompression, Surgical
MH  - Lumbar Vertebrae
MH  - Angiography
MH  - Retina/diagnostic imaging
MH  - *Neoplasms
PMC - PMC10474160
COIS- The authors declare no competing interests.
EDAT- 2023/09/02 05:42
MHDA- 2023/09/04 06:43
PMCR- 2023/09/01
CRDT- 2023/09/01 23:20
PHST- 2023/04/04 00:00 [received]
PHST- 2023/08/19 00:00 [accepted]
PHST- 2023/09/04 06:43 [medline]
PHST- 2023/09/02 05:42 [pubmed]
PHST- 2023/09/01 23:20 [entrez]
PHST- 2023/09/01 00:00 [pmc-release]
AID - 10.1038/s41598-023-40956-2 [pii]
AID - 40956 [pii]
AID - 10.1038/s41598-023-40956-2 [doi]
PST - epublish
SO  - Sci Rep. 2023 Sep 1;13(1):14371. doi: 10.1038/s41598-023-40956-2.